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Details for Product No. ABIN628968, Supplier: Log in to see
Cell Culture (CC), Functional Studies (Func)
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Sequence Quinolyl-Val-Asp-OPh
Characteristics A synthetic peptide that is potent, cell permeable, nontoxic and irreversibly inhibits caspase activity to blocks apoptosis. The new generation of caspase inhibitor is more stable in aqueous environment and exhibits several folds higher activity than the corresponding FMK caspase inhibitors. Q-VD-OPH is the inhibitor of choice for both in vitro and in vivo studies.
Purity > 95 % by HPLC
Molecular Weight 513.49 Da
Application Notes We recommend using 1-10 µM concentration for in vitro enzyme kinetics studies. For in vivo usage, quantity needs to be determined by researcher. 20 mg/Kg of body weight is a proper place to start.
Restrictions For Research Use only
Format Lyophilized
Handling Advice Protect from light and moisture.
Storage -20 °C
Expiry Date 12 months
Supplier Images
 image for Q-VD-OPH (ABIN628968) Q-VD-OPH
Product cited in: Quick, Leser, Clarke et al.: "Activation of intrinsic immune responses and microglial phagocytosis in an ex vivo spinal cord slice culture model of West Nile virus infection." in: Journal of virology, Vol. 88, Issue 22, pp. 13005-14, 2014 (PubMed).

Feng, Langereis, Lork et al.: "Enterovirus 2Apro targets MDA5 and MAVS in infected cells." in: Journal of virology, Vol. 88, Issue 6, pp. 3369-78, 2014 (PubMed).

Beck, Niessner, Smalley et al.: "Vemurafenib potently induces endoplasmic reticulum stress-mediated apoptosis in BRAFV600E melanoma cells. ..." in: Science signaling, Vol. 6, Issue 260, pp. ra7, 2013 (PubMed).

Frisan, Vandekerckhove, de Thonel et al.: "Defective nuclear localization of Hsp70 is associated with dyserythropoiesis and GATA-1 cleavage in myelodysplastic syndromes." in: Blood, Vol. 119, Issue 6, pp. 1532-42, 2012 (PubMed).

Höglund, Nilsson, Muralidharan et al.: "Therapeutic implications for the induced levels of Chk1 in Myc-expressing cancer cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 22, pp. 7067-79, 2011 (PubMed).

Novgorodov, Chudakova, Wheeler et al.: "Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis." in: The Journal of biological chemistry, Vol. 286, Issue 6, pp. 4644-58, 2011 (PubMed).

Rana, Gupta, Gomez et al.: "Securinine induces p73-dependent apoptosis preferentially in p53-deficient colon cancer cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 6, pp. 2126-34, 2010 (PubMed).

Yamanouchi, Morgan, Kato et al.: "Effects of caspase inhibitor on angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 30, Issue 4, pp. 702-7, 2010 (PubMed).

Höglund, Nilsson, Forshell et al.: "Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine." in: Blood, Vol. 113, Issue 18, pp. 4281-8, 2009 (PubMed).