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Luhtala, Vaajanen, Oksala, Valjakka, Vapaatalo: Activities of angiotensin-converting enzymes ACE1 and ACE2 and inhibition by bioactive peptides in porcine ocular tissues. in Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2009
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Rat (Rattus) Angiotensin I Converting Enzyme 2 ELISA Kit for Sandwich ELISA - ABIN431519
Liu, Hu, Wang, Zhang, Ma, Feng, Wang, Wang, Dong, Gao, Zhang, Zhang: Angiotensin-converting enzyme (ACE) 2 overexpression ameliorates glomerular injury in a rat model of diabetic nephropathy: a comparison with ACE inhibition. in Molecular medicine (Cambridge, Mass.) 2011
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Human Angiotensin I Converting Enzyme 2 ELISA Kit for Sandwich ELISA - ABIN415147
Molina Wolgien, Guerreiro da Silva, Pinto Nazário, Nakaie, Correa-Noronha, Ribeiro de Noronha, Facina: Genetic Association Study of Angiotensin II Receptor Types 1 (A168G) and 2 (T1247G and A5235G) Polymorphisms in Breast Carcinoma among Brazilian Women. in Breast care (Basel, Switzerland) 2014
Mouse (Murine) Angiotensin I Converting Enzyme 2 ELISA Kit for Competition ELISA - ABIN627486
Bae, Konvalinka, Fang, Zhou, Williams, Maksimowski, Song, Zhang, John, Oudit, Pei, Scholey: Characterization of the intrarenal renin-angiotensin system in experimental alport syndrome. in The American journal of pathology 2015
sporadic non-synonymous substitutions reduced the level of rh-ACE2 protein expression and did not support severe acute respiratory syndrome coronavirus entry effectively
Altogether, our study demonstrates that HFD feeding increases RAS activity and mediates glycemic dysregulation likely through loss of ACE2 present outside the islets but independently of changes in islet ACE2.
Results suggest that angiotensin converting enzyme 2 may reduce anxiety-like behavior by activating central Mas (show MAS1 ELISA Kits) receptor that facilitate GABA release onto pyramidal neurons within the basolateral amygdala.
These findings demonstrate that ACE2 plays a critical role in preventing RSV-induced lung injury, and suggest that ACE2 is a promising potential therapeutic target in the management of RSV-induced lung disease.
ACE2 overexpression significantly reduced the myocardial infarction-induced increase in apoptosis, macrophage infiltration, and HMGB1 (show HMGB1 ELISA Kits) and proinflammatory cytokine expression.
ACE2 regulates vascular function by modulating nitric oxide release.
MAS (show MAS1 ELISA Kits) receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular ACE2-angiotensin-(1-7)-MAS (show MAS1 ELISA Kits) axis functionality
ACE2 plays a novel role in heart disease associated with obesity wherein ACE2 negatively regulates obesity-induced epicardial adipose tissue inflammation and cardiac insulin (show INS ELISA Kits) resistance.
a Mas (show MAS1 ELISA Kits) receptor-mediated mechanism may stimulate pancreatic cell development
ACE2 deficiency exacerbates kidney inflammation, oxidative stress and adverse renal injury in the ApoE (show APOE ELISA Kits)-mutant mice through modulation of the nephrin (show NPHS1 ELISA Kits), NOX4 (show NOX4 ELISA Kits) and TNF-alpha (show TNF ELISA Kits)-TNFRSF1A (show TNFRSF1A ELISA Kits) signaling.
Hydronephrosis led to an increase of ACE (show ACE ELISA Kits) level and a decrease of ACE2 and Mas (show MAS1 ELISA Kits) receptor in the heart.
The objective of this study was to characterize the profiles of Ang-(1-7), MAS receptor, ACE(2), NEP and PEP during the ovulatory process in cattle.
In a pig model of acute pulmonary embolism leading to cardiac arrest, captopril infusion was associated with less mean right ventricular pressure overload after resuscitation, compared with saline infusion. The reduction in systemic and pulmonary vascular resistance associated with captopril may be by inhibiting the ACE (show ACE ELISA Kits)-Ang II (show AGT ELISA Kits)-AT1R (show AGTR1 ELISA Kits) axis and activating the ACE2/Ang-(1 (show ANGPT1 ELISA Kits)-7)/Mas (show MAS1 ELISA Kits) axis.
This study produced the full-length porcine ACE2 cDNA sequence and found polyunsaturated fatty acids could downregulate the expression of ACE2.
activation of the central rennin-angiotensin system in animals with chronic heart failure involves an imbalance of ACE (show ACE ELISA Kits) and ACE2 in regions of the brain that regulate autonomic function.
Overexpression of ACE2 inhibited atherosclerotic plaque inflammation response in hypercholesterolemic rabbits.
The findings of this study indicate that ACE-2 activity is reduced in AD and is an important regulator of the central classical ACE-1 (show ACE ELISA Kits)/Ang II (show AGT ELISA Kits)/AT1R (show AGTR1 ELISA Kits) axis of renin (show REN ELISA Kits)-angiotensin system, and also that dysregulation of this pathway likely plays a significant role in the pathogenesis of Alzheimer's disease.
Overexpression of ACE2 ameliorates Abeta-induced inflammatory response by activating the ACE2/Ang-(1-7)/Mas axis in human RPE cells.
Although further studies are required to determine how clusterin (show CLU ELISA Kits) suppresses non-specific cellular uptake in phagocytes, our data suggest that clusterin (show CLU ELISA Kits) plays a key role in the stealth effect of not only pegylated nanoparticles but also non-pegylated nanoparticles.
The ACE2 G8790A polymorphism in type 2 diabetes mellitus patients was correlated with cerebral stroke, and the A allele might be a risk factor of type 2 diabetes mellitus combined with cerebral stroke.
ollectrin, an ACE2 homolog with no catalytic activity, regulates blood pressure through an NO-dependent mechanism. Large body of experimental data confirmed sustained beneficial effects of ACE2/Ang-(1 (show ANGPT1 ELISA Kits)-7)/Mas (show MAS1 ELISA Kits) receptor axis activation on hypertension and vascular injury.
The potential contribution of the ACE2 to cardiovascular disease progression was addressed.
Serum ACE2 activity was significantly lower in acute ischemic stroke as compared to both control and stroke-alert patients, followed by an increase to control levels at three days.
Here, we review the role and effects of ACE2, ACE2 activators, Ang-(1 (show ANGPT1 ELISA Kits)-7) and synthetic Mas (show MAS1 ELISA Kits) receptor agonists in the control of inflammation and fibrosis in cardiovascular and renal diseases and as counter-regulators of the ACE (show ACE ELISA Kits)-Ang II (show AGT ELISA Kits)-AT1 (show AGTR1 ELISA Kits) axis.
ACE2 overexpression inhibited cell growth.
Downregulation of ACE2/Ang-(1 (show ANGPT1 ELISA Kits)-7)/Mas (show MAS1 ELISA Kits) axis stimulates breast cancer metastasis through the activation of store-operated calcium entry and PAK1 (show PAK1 ELISA Kits)/NF-kappaB (show NFKB1 ELISA Kits)/Snail1 (show SNAI1 ELISA Kits) pathways.
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
, angiotensin-converting enzyme 2
, angiotensin-converting enzyme homolog
, metalloprotease MPROT15
, peptidyl-dipeptidase A
, angiotensin I converting enzyme 2
, anigotensin-converting enzyme-related carboxypeptidase
, renal angiotensin-converting enzyme 2