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Human TGFB1 Protein expressed in CHO Cells - ABIN809732
Farges, Romeas, Melin, Pin, Lebecque, Lucchini, Bleicher, Magloire: TGF-beta1 induces accumulation of dendritic cells in the odontoblast layer. in Journal of dental research 2003
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Human TGFB1 Protein expressed in HEK293 - ABIN2039657
Munger, Harpel, Gleizes, Mazzieri, Nunes, Rifkin: Latent transforming growth factor-beta: structural features and mechanisms of activation. in Kidney international 1997
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Human TGFB1 Protein expressed in HEK293 - ABIN2039654
Loeys, Schwarze, Holm, Callewaert, Thomas, Pannu, De Backer, Oswald, Symoens, Manouvrier, Roberts, Faravelli, Greco, Pyeritz, Milewicz, Coucke, Cameron, Braverman, Byers, De Paepe, Dietz: Aneurysm syndromes caused by mutations in the TGF-beta receptor. in The New England journal of medicine 2006
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Human TGFB1 Protein expressed in HEK293 - ABIN2039655
Benke, Ágg, Szilveszter, Tarr, Nagy, Pólos, Daróczi, Merkely, Szabolcs: The role of transforming growth factor-beta in Marfan syndrome. in Cardiology journal 2013
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Human TGFB1 Protein expressed in HEK-293 Cells - ABIN805198
Huang, Zhao, Fields, Ransohoff, Zhou: Imatinib attenuates skeletal muscle dystrophy in mdx mice. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
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Rat (Rattus) TGFB1 Protein expressed in Human Cells - ABIN2009188
Assoian, Komoriya, Meyers, Miller, Sporn: Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. in The Journal of biological chemistry 1983
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Human TGFB1 Protein expressed in HEK-293 Cells - ABIN2733505
Wang, Reece, Yang: Oxidative stress is responsible for maternal diabetes-impaired transforming growth factor beta signaling in the developing mouse heart. in American journal of obstetrics and gynecology 2015
Rat (Rattus) TGFB1 Protein expressed in Escherichia coli (E. coli) - ABIN1081012
Elfayomy, Almasry, El-Tarhouny, Eldomiaty: Human umbilical cord blood-mesenchymal stem cells transplantation renovates the ovarian surface epithelium in a rat model of premature ovarian failure: Possible direct and indirect effects. in Tissue & cell 2016
TGF-beta1 regulated pAKT (show AKT1 Proteins) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 in regulating intestinal homeostasis and EC integrity.
These findings suggest that FBLN5 (show FBLN5 Proteins) may interfere with choroidal neovascularization by downregulating VEGF (show VEGFA Proteins), CXCR4 (show CXCR4 Proteins), and TGFB1 expression and inhibiting choroidl endothelial cell proliferation.
SIV infection of rhesus macaques results in the emergence of IL-17 (show IL17A Proteins)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 (show IL18 Proteins) expression.
SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8 (show CD8A Proteins)+ T cells from mesentric lymph nodes.
transforming growth factor beta (TGFbeta) is required for hematopoietic progenitor cell specification. The requirement for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesting that the former programs the hemogenic endothelium and the latter drives endothelial-to-hematopoietic tran...
The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a (show LDB2 Proteins).
TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 (show SMAD5 Proteins) mediated pathway.
PCSK7 (show PCSK7 Proteins) is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.
TGFbeta signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration.
TGFbeta1 plays a role in zebrafish keratocyte migration.
data presented show that Zili suppresses TGF-beta signaling by physically associating with Smad4 (show SMAD4 Proteins) and preventing the formation of Smad2 (show SMAD2 Proteins)/3/4 and Smad1 (show SMAD1 Proteins)/5/9/4 complexes
TGF-beta1 acts at multiple sites, including LH receptor (show LHCGR Proteins), 20beta-HSD (show HAL Proteins) and membrane progestin receptor-beta (show PAQR8 Proteins), to inhibit zebrafish oocyte maturation
These data suggest Pez (show PTPN14 Proteins) plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.
Data show that Rock2 (show ROCK2 Proteins) acts as a negative regulator of the TGFbeta signaling pathway.
These data indicate that TGF-beta signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.
R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 (show SYCP3 Proteins) serves as a vegetally enriched, intrinsic factor (show GIF Proteins) to ensure a prepared status of Smads for their activation.
the present in vitro system, which permits not only the cell contraction-mediated cell sorting but also the TGF-b-directed mesodermal induction such as cartilage formation, may fairly reflect the embryogenesis in vivo.
Loss of XTgfbi impaired blastopore formation and dorsal tissue morphogenesis.
TGF-beta signaling has a role in nuclear localization of transcription factor Smad4 (show SMAD4 Proteins)
sortilin (show SORT1 Proteins) negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway
The LOXL1 (show LOXL1 Proteins) SNPs, rs1048661 and rs3825942, are associated with PXF (show PEX19 Proteins) in the South Indian population correlating with lowered LOX (show LOX Proteins) activity in the aqueous humor. The increased level of total TGF-beta in the aqueous humor of PXF (show PEX19 Proteins) cases is possibly associated with LOX (show LOX Proteins) regulation which needs further investigation.
it is likely that TGFbeta1 and FL, both abundantly produced by bone marrow stromal cells, function in a coordinated manner to render mixed-lineage leukemia gene-rearranged acute lymphoblastic leukemia cells chemoresistant
identified trihydroxyphenolic compounds as potent blockers of TGF-beta1 responses (IC50 ~50 nM), Snail1 (show SNAI1 Proteins) expression, and collagen deposition in vivo in models of pulmonary fibrosis and collagen-dependent lung cancer metastasis.
that CCR7 (show CCR7 Proteins) mediates TGF-beta1-induced MMP2 (show MMP2 Proteins)/9 expression through NF-kappaB (show NFKB1 Proteins) signaling
TGF-beta1 inhibited IL-33-mediated cytokine release from human mast cells. TGF-beta1 also suppressed the combined effects of IL-33 and IgE-mediated activation on mouse and human mast cells.
High TGFB1 expression is associated with high grade glioma.
Transforming growth factor-beta1 upregulation triggers pulmonary artery smooth muscle cell proliferation and apoptosis imbalance in rats with hypoxic pulmonary hypertension via the PTEN/AKT (show AKT1 Proteins) pathways
Hypoxia enhances canonical TGFbeta signalling, and appears to be a key determinant of Snail's differential involvement in endothelial cell responses to TGFbeta1 versus TGFbeta2.
Our results suggest that TNF-alpha (show TNF Proteins), IFN-gamma (show IFNG Proteins) and TGF-beta function cooperatively to regulate the expressions of IL-6 (show IL6 Proteins) and MMP-9 (show MMP9 Proteins), and may play important roles in pathological behaviour of AMs (show MAT1A Proteins), such as bone resorption.
No relationship was found between the studied polymorphisms (14094 ACE (show ACE Proteins) gene, rs1800469 gene TGFbeta1, GNB3 (show GNB3 Proteins) gene rs5443, rs5186 AGTR1 (show AGTR1 Proteins) gene) and the occurrence of primary vesicoureteral reflux.
Activated TGF-beta signaling rescued miR (show MYLIP Proteins)-143-reduced FSHR (show FSHR Proteins) and intracellular signaling molecules, and miR (show MYLIP Proteins)-143-induced porcine granulosa cell apoptosis.
TGF-beta1-induced epithelial-myofibroblast plasticity is FAK (show PTK2 Proteins)- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK (show PTK2 Proteins) signaling is inhibited.
this study shows that TGF-beta1 protects intestinal integrity and influences Smad (show SMAD1 Proteins) and MAPK (show MAPK1 Proteins) signal pathways in intestinal epithelium cells after TNF-alpha (show TNF Proteins) challenge
this study shows that anemonin may ameliorate LPS (show IRF6 Proteins)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR (show EGFR Proteins) signaling pathways
The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.
Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.
The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10 (show IL10 Proteins), and IL-6 (show IL6 Proteins) in ovarian follicles are reported.
Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (show TGFB2 Proteins) and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.
TGF-beta1, via TGF-beta1 receptor I and p38 MAPK (show MAPK14 Proteins) signaling, reduces CFTR (show CFTR Proteins) expression to impair CFTR (show CFTR Proteins)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (show CFTR Proteins) mutations and ultimately would compromise male fertility.
High yield isolation of BMP-2 (show BMP2 Proteins) from bone and in vivo activity of a combination of BMP-2 (show BMP2 Proteins)/TGF-beta1.
Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF (show FGF2 Proteins) expression through the activation of AP-1 (show JUN Proteins) and NF-kappaB (show NFKB1 Proteins) in bovine mammary gland fibroblasts.
The results identify TGFB1 and ESRRA (show ESRRA Proteins) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.
the combined treatment with TGF-beta1 and BMP-7 (show BMP7 Proteins) or treatment first with TGF-beta1 followed by BMP-7 (show BMP7 Proteins) was more effective than other treatment groups in both chondrogenic differentiation and SZP (show PRG4 Proteins) secretion.
Tenascin-X (show TNXB Proteins) promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.
a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1 (show SMAD1 Proteins)/5/8 and Smad2 (show SMAD2 Proteins)/3 channels through a negative feedback loop dependent on Smad7 (show SMAD7 Proteins).
Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.
A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.
Data show that TGF-beta pathways operate during ovarian fetal development, and fibrillin 3 is highly expressed at a critical stage early in developing human and bovine fetal ovaries.
Role of TGF-beta1 and TNF-alpha (show TNF Proteins) in IL-1beta (show IL1B Proteins) mediated activation of proMMP-9 in pulmonary artery smooth muscle cells: involvement of an aprotinin sensitive protease.
vascular endothelial growth factor indirectly stimulates smooth muscle cell proliferation and migration through the modulation of basic fibroblast growth factor (show FGF2 Proteins) and transforming growth factor beta(1) released by endothelial cells
TGF-beta and PPARalpha (show PPARA Proteins) signaling pathways are involved in radiation-induced heart fibrosis, metabolic dysregulation, and impaired heart contractility, a pathophysiological condition that is often observed in patients that received high radiation doses in thorax.
Data show that Clostridium difficile Toxin A induces TGF-beta1 signaling pathway activation and suggest that this pathway might play a protective role against the effect of C. difficile-toxin.
These findings implicate TGF-beta-Smad2 (show SMAD2 Proteins)/3 signaling in activated tissue-resident cardiac fibroblasts as principal mediators of the fibrotic response.
Targeted elimination of TGFbetaR2 in TAGLN (show TAGLN Proteins)(+) cells impairs midline closure and prevents the correct subsequent patterning of the musculature and skeletal components.
Study found that in endothelial cells thrombospondin-4 (TSP-4 (show THBS4 Proteins)), a secreted extracellular matrix protein, is upregulated in response to TGF-beta1 and mediates the effects of TGF-beta1 on angiogenesis.
a novel and intimate link between the protein kinase (show CDK7 Proteins) NDR1 (show STK38 Proteins) and TGFbeta signaling
the methyltransferase Set9 potentiates TGF-beta signaling by targeting Smad7 (show SMAD7 Proteins), an inhibitory downstream effector.
These results indicate that bidirectional communication between ovarian cancer (OvCa) cells and MC-derived CAFs (show TBX1 Proteins), via TGF-beta-mediated MMT, seems to be crucial to form a suitable metastatic niche. We suggest MMT as a possible target for therapeutic intervention and a potential source of biomarkers for improving OvCa diagnosis and/or prognosis.
Tfrc deletion dramatically suppressed both transforming growth factor-beta (TGF-beta) and bone morphogenetic protein (BMP) signaling in cranial neural crest cell-derived mandibular tissues.
Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1/Smad3 (show SMAD3 Proteins) signaling pathway in chronic heart failure .
study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.
cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (show NFKB1 Proteins), and the amelioration of disc degradation.
that prenatal tracheal occlusion increases TGF-beta/Rho kinase (show ROCK1 Proteins) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs
observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering
Smad7 (show SMAD7 Proteins) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch (show NOTCH1 Proteins) signaling target in limbal epithelial stem cells.
the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b
After NOTCH1 (show NOTCH1 Proteins) knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (show Vcan Proteins) and collagen II.
TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.
TGF beta is involved in the pathogenesis of tympanosclerosis.
There was significantly higher expression of TGF-beta1 and MMP-9 (show MMP9 Proteins) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.
Within the limitations of the study design, production of COMP (show COMP Proteins) during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.
Peritoneal TGF-beta(1) concentration was higher in horses with severe gastrointestinal diseases, in horses with an altered peritoneal fluid, and in nonsurvivors.
This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.
transforming growth factor beta1
, transforming growth factor, beta 1
, transforming growth factor, beta-induced, 68kDa
, transforming growth factor-beta-induced protein ig-h3-like
, transforming growth factor beta-1-like
, transforming growth factor beta 4
, transforming growth factor beta-1
, TGF-beta 1 protein
, latency-associated peptide
, transforming growth factor, beta 1 (Camurati-Engelmann disease)
, transforming growth factor-beta-1
, TGF-beta 1
, transforming growth factor-beta 1
, transforming growth factor, beta-1
, transforming growth factor beta 1
, regulatory protein
, transforming growth factor-beta
, tgf beta
, tgf-beta 5
, transforming gorwth factor-Beta5
, transforming growth factor-B5
, transforming growth factor-beta 5
, Transforming growth factor beta-1