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study showed that stimulated, human B lymphocytes produce active TGF-beta1 from surface GARP/latent TGF-beta1 complexes with isotype switching to IgA production.
GARP (show CNGB1 Proteins) plays an important role in the pathogenesis of atopic dermatitis.
CD4 (show CD4 Proteins)(+) CD25 (show IL2RA Proteins)(+) GARP (show CNGB1 Proteins)(+) Treg cells are defective in dilated cardiomyopathy patients and GARP (show CNGB1 Proteins) seems to be a better molecular definition of the regulatory phenotype.
these results define the oncogenic effects of the GARP (show CNGB1 Proteins)-TGFbeta (show TGFB1 Proteins) axis in the tumor microenvironment
The CD109 protein was up-regulated in hepatocellular carcinoma tissue compared with adjacent noncancerous tissue. CD109 shRNA knockdown delayed the G1-S phase transition, abrogated cell proliferation, and increased cell apoptosis. Furthermore, CD109 impaired TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling through control of p-smad2 (show SMAD2 Proteins).
CD109 is a putative biomarker for identifying a high-risk group among DLBCL patients.
The most common HPA (show HPSE Proteins) genotypes among Saudis were HPA-1 (show HPSE Proteins) a + b- (75%), HPA-2 a + b- (62%), HPA-3 a + b- (51.5%), HPA (show HPSE Proteins)-4 a + b- (99%), HPA-5 (show ITGA2 Proteins) a + b- (76.5%), HPA (show HPSE Proteins)-6 a + b- (100%) and HPA (show HPSE Proteins)-15 a + b + (50%). The prevalent allele among the HPA (show HPSE Proteins) systems was (a), except in the HPA (show HPSE Proteins)-15 system where the (b) allele was found in 52% of the subjects.
LRRC32 (show LRRC32 Proteins) expression is significantly upregulated in human masticatory mucosa during wound healing
Expression levels of CD109 was reduced significantly in psoriasis. Lower expression of CD109 and TGF-beta (show TGFB1 Proteins) RI was highly correlated with higher expression of Smad7 (show SMAD7 Proteins) and Ki67 (show MKI67 Proteins), suggesting that CD109 may induce the pathogenesis of psoriasis through Smad7 (show SMAD7 Proteins)-mediated degradation of TGF-beta (show TGFB1 Proteins) RI.
sCD109 can bind TGF-beta (show TGFB1 Proteins), inhibit TGF-beta (show TGFB1 Proteins) binding to its receptors and decrease TGF-beta (show TGFB1 Proteins) signalling and TGF-beta (show TGFB1 Proteins)-induced cellular responses.
platelet and endothelial GARP (show LRRC32 Proteins) are not important in hemostasis and thrombosis in mice
Small-scale in vivo screening identified several genes, including Cd109, that encode novel pro-metastatic factors. We uncovered signaling mediated by Janus kinases (Jaks) and the transcription factor Stat3 (show STAT3 Proteins) as a critical, pharmacologically targetable effector of CD109-driven lung cancer metastasis
CD109 differentially regulates TGF-beta (show TGFB1 Proteins)-induced ALK1 (show ACVRL1 Proteins)-Smad1 (show SMAD1 Proteins)/5 versus ALK5 (show TGFBR1 Proteins)-Smad2 (show SMAD2 Proteins)/3 pathways, leading to decreased extracellular matrix production in the skin; epidermal CD109 expression regulates dermal function through a paracrine mechanism
the GARP (show LRRC32 Proteins)/LTGF-beta1 complex on Treg cells is a major source of TGF-beta1 (show TGFB1 Proteins) needed for induction of pTreg cells during the process of oral tolerance.
GP96 (show HSP90B1 Proteins) serves as an essential chaperone for the cell-surface protein (show CD28 Proteins) glycoprotein A repetitions predominant (GARP (show LRRC32 Proteins)), which is a docking receptor for latent membrane-associated TGF-beta (show TGFB1 Proteins) (mLTGF-beta).
CD109 decreases extracellular matrix production and fibrotic responses during hypoxic wound healing
CD109 is present in serum as a soluble form, and suggest its potential as a novel tumor marker in patients with cancers that express CD109.
CD109 might be an important regulator of osteoclastogenesis.
findings demonstrate that CD109 overexpression in the epidermis reduces inflammation and granulation tissue area and improves collagen organization in vivo.
Induction of both Th17-producing cells and Tregs is caused preferentially by Tregs expressing the latent TGF-beta1 (show TGFB1 Proteins)/GARP (show LRRC32 Proteins) complex on their cell surface rather than by secreted latent TGF-beta1 (show TGFB1 Proteins).
This gene encodes a member of the alpha2-macroglobulin/complement superfamily. The encoded GPI-linked glycoprotein is found on the cell surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene.
150 kDa TGF-beta-1-binding protein
, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7
, CD109 antigen
, Gov platelet alloantigens
, activated T-cell marker CD109
, platelet-specific Gov antigen
, CD109 molecule
, CD109 antigen-like
, GPI-anchored alpha 2 macroglobulin-related protein
, GPI-anchored alpha-2 macroglobulin-related protein