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MyD88 (show MYD88 ELISA Kits) signaling in lysozyme (show LYZ ELISA Kits) M and CD11c-expressing myeloid cells, as well as in pulmonary epithelial cells, is critical to restore inflammatory cytokine and antimicrobial peptide (show cAMP ELISA Kits) production, leading to efficient neutrophil recruitment and enhanced bacterial clearance.
Results implicate a monocytic origin of CD11c(+) cells in inflamed islets and suggest that therapeutic regulatory T cells directly or indirectly regulate their influx by altering the chemotactic milieu in the islets.
this study shows that PU.1 functions as a positive regulator of CD11c gene expression by directly binding to the Itgax promoter and through transactivation of the Irf4 (show IRF4 ELISA Kits) gene
Murine CD11c+ T cells analyzed by flow cytometry display markers associated with non-conventional T cell subsets, including gammadelta T cells and invariant natural killer T (iNKT) cells.
Data concluded that the ablation of CD11c(hi) dendritic cells provided a subsidiary impact on blood-brain barrier (BBB (show ALMS1 ELISA Kits)) integrity and the expression of tight junction/adhesion molecules, thereby leading to exacerbated Japanese encephalitis (JE) progression.
CD11c(+) monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23 (show IL23A ELISA Kits).
data demonstrate that CD11c(hi) DCs provide a critical and unexpected role to preserve the immune-privileged CNS in lethal neuroinflammation via regulating the differentiation, function, and trafficking of CD11b(+)Ly-6C(hi) monocytes.
The generation of mouse line with Flip deficiency in cells that express cre under the CD11c promoter is reported.
Probucol effectively retarded atherosclerosis at least partly through lipid-lowering and inhibiting immune maturation of CD11c dendritic cells in STZ-induced diabetic LDLR (show LDLR ELISA Kits) mice.
Dual function of PPARgamma (show PPARG ELISA Kits) in CD11c+ cells ensures immune tolerance in the airways.
CD11c, expressed not only in Hairy cell leukemia but also in dendritic cells, macrophages and monocytes is a differentiation marker for inflammation. Prolonged inflammation in the microenvironment of CLL cells may cause a susceptibility to autoimmune disorders and secondary tumors in CLL, in this way, an increase in mortality.
We can achieve possible clinical significance of lymphoma tumor microenvironments through CD11c and FOXP3 (show FOXP3 ELISA Kits) immunohistochemistry stains in extranodal diffuse large B-cell lymphoma patients receiving R-CHOP (show DDIT3 ELISA Kits) therapy.
Circulating CD11c+ T cells were associated with the expression of multiple adhesion molecules in women, suggesting that these cells have high tissue homing potential. These data suggest that CD11c expression distinguishes a population of circulating T cells during bacterial infection with innate capacity and mucosal homing potential.
CD8 (show CD8A ELISA Kits)+ T cells of Behcet's disease patients exhibited increased CD11c expression levels, which may contribute to disease pathogenesis.
High expression of CD11c decreased the risk of death and relapse, and may be regarded as an alternative indicator of favorable prognosis in patients with gastric cancer.
the CD11c molecule possesses four different cellular patterns in the periprosthetic tissues.
Data show that secreted aspartic protease 2 (Sap2) of Candida albicans inactivates human macrophage complement factor H (factor H (show CFH ELISA Kits)), factor H (show CFH ELISA Kits)-receptors CD11b/CD18 (show ITGAM ELISA Kits) and CD11c/CD18 (show ITGB2 ELISA Kits).
Data show that the percentage of CD11c positive antigen presenting cells (CD11c(+) APCs (show APCS ELISA Kits)) in the peripheral blood of active pulmonary tuberculosis (APT) patients was much higher than that in the controls.
Data suggest that blood neutrophils expressing CD11c antigen and EMR2 (show EMR2 ELISA Kits) protein be considered as potential biomarkers for sepsis and systemic inflammatory response syndrome (SIRS), respectively.
Modification of Levels of Adhesion Molecule (show NCAM1 ELISA Kits) Expression of Human Innate Immune Cells by Glycopolymers of Marine Bacteria
This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles.
CD11 antigen-like family member C
, CD11C (p150) alpha polypeptide
, complement receptor 4
, integrin aX
, integrin alpha-X
, leukocyte adhesion glycoprotein p150,95 alpha chain
, leukocyte adhesion receptor p150,95
, integrin alpha X (Cd11c)
, integrin alpha-D
, integrin, alpha X (antigen CD11C (p150), alpha polypeptide)
, leu M5, alpha subunit
, leukocyte surface antigen p150,95, alpha subunit
, myeloid membrane antigen, alpha subunit
, p150 95 integrin alpha chain