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Overexpression of AIM2 in hepatocellular carcinoma (HCC (show FAM126A Proteins)) cells suppressed mammalian target of rapamycin (mTOR (show FRAP1 Proteins))-S6K1 (show RPS6KB1 Proteins) pathway and further inhibited proliferation of HCC (show FAM126A Proteins) cells.
AIM2 is an important component of the inflammasome in tegumentary leishmaniasis (TL) patients and is directly associated with the severity of lesions.
TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.
AIM2 contributes to the maintenance of intestinal integrity via Akt (show AKT1 Proteins) and protects against Salmonella mucosal infection.
study identifies the AIM2 inflammasome and cGAS/IFI16 (show IFI16 Proteins)-STING-type I IFN pathway as a novel mechanism for host innate immunity to the ALVAC vaccine vector.
Study conclude that functional AIM2 is preferentially expressed in adult human CD27 (show CD27 Proteins)+ B-cells, but is absent in cord blood mononuclear cells.
results suggest that the function of AIM2 is focused on the innate immune response, and AIM2 is a detrimental host factor for influenza-induced lung injury and mortality.
knockdown of AIM2 by small interfering RNA attenuated caspase-1 (show CASP1 Proteins) activation. the results suggest that EBV infection of human monocytes induces caspase-1 (show CASP1 Proteins)-dependent IL-1beta (show IL1B Proteins) production, and that AIM2, acting as an inflammasome, is involved in this response.
These data indicate that human cytomegalovirus pUL83 interacts with human AIM2 in the cytoplasm during the early stages of virus infection. The pUL83/AIM2 interaction deregulates the activation of AIM2 inflammasome.
The findings reveal an age-dependent reduction of AIM2 expression and activation which may explain reduced cytokine responses to the cytosolic DNA mimic poly(dA:dT) in healthy elderly individuals. Reduced AIM2-mediated sensing with age may contribute to increased vulnerability to bacterial or viral infections in the elderly.
AIM2 cytosolic DNA sensor may conjugate competitively with cytosolic Mycobacterium bovis DNA to restrict Mycobacterium bovis induced STING-TBK1 (show TBK1 Proteins)-dependent autophagy activation and IFN-beta (show IFNB1 Proteins) secretion.
this study shows that aim2-like receptors are dispensable for the type I interferon (show IFNA Proteins) response to transfected DNA ligands, DNA virus infection, and lentivirus infection
These results show for the first time that AIM2 plays an important anti-inflammatory, yet inflammasome-independent function in cardiomyocytes
These results demonstrate a central role for the AIM2 inflammasome in preventing dysbiosis and intestinal inflammation through regulation of the IL-18 (show IL18 Proteins)/IL-22BP (show IL22RA2 Proteins)/IL-22 (show IL22 Proteins) and STAT3 (show STAT3 Proteins) pathway
AIM2 senses radiation-induced DNA damage in the nucleus to mediate inflammasome activation and cell death.
Molecular docking analysis reveals that the conformation switching may be important for the autoinhibition of the AIM2 protein.
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
absent in melanoma 2
, interferon-inducible protein AIM2-like
, interferon-inducible protein AIM2
, interferon-inducible protein 210
, interferon-inducible protein p210