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Human AIM2 Protein expressed in Baculovirus infected Insect Cells - ABIN2004480
DeYoung, Ray, Su, Anzick, Johnstone, Trapani, Meltzer, Trent: Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma. in Oncogene 1997
The findings reveal an age-dependent reduction of AIM2 expression and activation which may explain reduced cytokine responses to the cytosolic DNA mimic poly(dA:dT) in healthy elderly individuals. Reduced AIM2-mediated sensing with age may contribute to increased vulnerability to bacterial or viral infections in the elderly.
The extent of NLRC3 and AIM2 gene reduction was correlated with cancer progression.
Molecular docking analysis reveals that the conformation switching may be important for the autoinhibition of the AIM2 protein.
A significant upregulation of the PYHIN inflammasomes AIM2 and IFI16 (show IFI16 Proteins) in active inflammatory bowel disease versus controls was found.
Lung tumor-associated plasmacytoid dendritic cells (pDCs) are responsive to the activation of AIM2 that promotes calcium efflux and reactive oxygen species from mitochondria, leading to calpain activation and high levels of IL-1alpha.
analysis of a subset of inflammasome receptors including NLRP3 (show NLRP3 Proteins), NLRC4 (show NLRC4 Proteins) and AIM2 that triggers formation of the micrometer-sized spherical supramolecular complex called the ASC (show PYCARD Proteins) speck
pyrin (show MEFV Proteins) domain drives both filament formation and dsDNA binding
activation of the AIM2 inflammasome did not require a priming signal in ascitic fluid-derived macrophages, demonstrating the preactivated state of the inflammasome in these cells.
These results suggest that AIM2 expressed in human dental pulp plays an important role in the immune defense by activating the inflammasome signaling pathway.
The comparison shows mouse AIM2 PYD domain adopts a unique alpha2-alpha3 helix conformation distinct from its human homologues, but similar to the pyrin domain of human NLRP10/PYNOD, which belongs to another family.
in vitro activation of the AIM2 inflammasome in murine macrophages and dendritic cells leads to reduced activation of the STING pathway, in part through promoting caspase-1 (show CASP1 Proteins)-dependent cell death.
A tissue-specific role for the AIM2 inflammasome as a sensor for endogenous DNA species in the course of a ligand-dependent autoinflammatory condition.
AIM2 inflammsome is functionally redundant in the inflammasomemediated caspase-1 (show CASP1 Proteins) activation and IL-1beta (show IL1B Proteins) production during P. aeruginosa infection.
Mice lacking both AIM2 and NLRP3 (show NLRP3 Proteins) fail to confine Aspergillus hyphae to inflammatory foci, leading to widespread hyphal dissemination to lung blood vessels.
AIM2 reduced Akt (show AKT1 Proteins) activation and tumor burden in colorectal cancer models, while an Akt (show AKT1 Proteins) inhibitor reduced tumor load in Aim2(-/-) mice
For the first time, this paper demonstrated that miR (show MLXIP Proteins)-223 acted to inhibit IL-1beta (show IL1B Proteins) production via AIM2 pathway, suppressing Kupffer cells pro-inflammatory activation at the early stage of ALF (show GTF2A1L Proteins). Thus, it played an important role in the pathogenesis of ALF (show GTF2A1L Proteins).
Study found that Aim2-deficient mice were hypersusceptible to colonic tumor development. Production of inflammasome-associated cytokines and other inflammatory mediators was largely intact in Aim2-deficient mice; however, intestinal stem cells were prone to uncontrolled proliferation.
these results reveal a specific requirement for IRF1 (show IRF1 Proteins) and GBPs in the liberation of DNA for sensing by AIM2 depending on the pathogen encountered by the cell.
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
absent in melanoma 2
, interferon-inducible protein AIM2-like
, interferon-inducible protein AIM2
, interferon-inducible protein 210
, interferon-inducible protein p210