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Browse our Chromosome 6 Open Reading Frame 150 Proteins (C6orf150)

Full name:
Chromosome 6 Open Reading Frame 150 Proteins (C6orf150)
On www.antibodies-online.com are 5 Chromosome 6 Open Reading Frame 150 (C6orf150) Proteins from 4 different suppliers available. Additionally we are shipping Chromosome 6 Open Reading Frame 150 Antibodies (37) and many more products for this protein. A total of 46 Chromosome 6 Open Reading Frame 150 products are currently listed.
Synonyms:
C6orf150, cGAS, h-cGAS
list all proteins Gene Name GeneID UniProt
C6orf150 115004 Q8N884
C6orf150    

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Chromosome 6 Open Reading Frame 150 Proteins (C6orf150) by Origin

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More Proteins for Chromosome 6 Open Reading Frame 150 Interaction Partners

Human Chromosome 6 Open Reading Frame 150 (C6orf150) interaction partners

  1. Primary human endothelial cells mount robust type I interferon (show IFNA Proteins) responses to human cytomegalovirus that are dependent upon cyclic GMP (show NT5C2 Proteins)-AMP (show APRT Proteins) synthase (cGAS), STING, and interferon regulatory factor 3 (IRF3 (show IRF3 Proteins)) signaling.

  2. cGAS and STING are intracellular sensors that activate the interferon (show IFNA Proteins) pathway in response to virus infection. [review]

  3. cGAS silencing inhibited production of proinflammatory cytokines and matrix metalloproteinases (MMPs) as well as AKT (show AKT1 Proteins) and ERK (show EPHB2 Proteins) phosphorylation in TNFalpha (show TNF Proteins)-stimulated fibroblast-like synoviocytes

  4. A STING-dependent, cGAS-independent pathway important for full interferon (show IFNA Proteins) production and antiviral control of enveloped RNA viruses.

  5. By directly binding to cGAS, LANA, and particularly, a cytoplasmic isoform, inhibit the cGAS-STING-dependent phosphorylation of TBK1 (show TBK1 Proteins) and IRF3 (show IRF3 Proteins) and thereby antagonize the cGAS-mediated restriction of KSHV lytic replication.

  6. TRIM21 (show TRIM21 Proteins)-induced exposure of the viral genome promotes sensing of DNA and RNA viruses by cGAS and RIG-I (show DDX58 Proteins)

  7. cGAS is an innate sensor of Mycobacterium tuberculosis.Mycobacterium tuberculosis differentially activates cGAS- and inflammasome-dependent intracellular immune responses through ESX-1 (show ESX1 Proteins).

  8. Study found that PQBP1 (show PQBP1 Proteins) directly binds to reverse-transcribed HIV-1 DNA and interacts with cGAS to initiate an IRF3 (show IRF3 Proteins)-dependent innate response.

  9. Studies in THP-1 knockout cells revealed that the recognition of RNA:DNA hybrids is completely attributable to the cGAS-STING pathway.

  10. IFI16 (show IFI16 Proteins) and cGAS cooperate in a novel way to sense nuclear herpesviral DNA and initiate innate signaling

Chromosome 6 Open Reading Frame 150 (C6orf150) Protein Profile

Protein Summary

Exhibits broad antiviral activity, most probably causing an early viral translation block.

Alternative names and synonyms associated with Chromosome 6 Open Reading Frame 150 (C6orf150)

  • chromosome 6 open reading frame 150 (C6orf150)
  • Mab-21 domain containing 1 (MB21D1)
  • C6orf150 protein
  • cGAS protein
  • h-cGAS protein

Protein level used designations for C6orf150

chromosome 6 open reading frame 150 , cGAMP synthase , cyclic GMP-AMP synthase , mab-21 domain-containing protein 1 , protein MB21D1

GENE ID SPECIES
421864 Gallus gallus
100137406 Papio anubis
115004 Homo sapiens
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