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Type I IFN is detrimental to the host, and dysregulation of iron homeostasis genes may explain lower bacteria survival in cGAS(-/-) and TLR4 (show TLR4 Proteins)(-/-) cells.
the current study demonstrated that the DNA sensor cGAS is dynamically modified by SUMO
while IFI16 (show IFI16 Proteins) induces cytokines, only cGAS activates STING/TBK-1 (show TBK1 Proteins)/IRF3 (show IRF3 Proteins) and apoptotic responses upon herpes simplex virus 1 and human cytomegalovirus infections; findings show that IFI16 (show IFI16 Proteins), not cGAS or PML (show PML Proteins), represses HSV-1 gene expression, reducing virus
cGAs recognizes bacterial/viral DNA, and is a strong activator of STING that can further activate IRF3 (show IRF3 Proteins) and subsequent type I interferon (show IFNA Proteins) production. (Review)
Data suggest that the N terminus enhanced the activity of core-cyclic GMP (show NT5C2 Proteins)-AMP (show APRT Proteins) synthase (cGAS) by facilitating formation of a monomeric complex of cGAS and DNA.
Primary human endothelial cells mount robust type I interferon (show IFNA Proteins) responses to human cytomegalovirus that are dependent upon cyclic GMP (show NT5C2 Proteins)-AMP (show APRT Proteins) synthase (cGAS), STING, and interferon regulatory factor 3 (IRF3 (show IRF3 Proteins)) signaling.
cGAS and STING are intracellular sensors that activate the interferon (show IFNA Proteins) pathway in response to virus infection. [review]
cGAS silencing inhibited production of proinflammatory cytokines and matrix metalloproteinases (MMPs) as well as AKT (show AKT1 Proteins) and ERK (show EPHB2 Proteins) phosphorylation in TNFalpha (show TNF Proteins)-stimulated fibroblast-like synoviocytes
A STING-dependent, cGAS-independent pathway important for full interferon (show IFNA Proteins) production and antiviral control of enveloped RNA viruses.
By directly binding to cGAS, LANA, and particularly, a cytoplasmic isoform, inhibit the cGAS-STING-dependent phosphorylation of TBK1 (show TBK1 Proteins) and IRF3 (show IRF3 Proteins) and thereby antagonize the cGAS-mediated restriction of KSHV lytic replication.
Exhibits broad antiviral activity, most probably causing an early viral translation block.
chromosome 6 open reading frame 150
, cGAMP synthase
, cyclic GMP-AMP synthase
, mab-21 domain-containing protein 1
, protein MB21D1