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Petrey, Flanagan-Steet, Johnson, Fan, De la Rosa, Haskins, Nairn, Moremen, Steet: Excessive activity of cathepsin K is associated with cartilage defects in a zebrafish model of mucolipidosis II. in Disease models & mechanisms 2012
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Human Cathepsin S ELISA Kit for Sandwich ELISA - ABIN415099
Gu, Lü, Chen, Zhou, Song, Jin, Liu: Relationship between plasma cathepsin S and cystatin C levels and coronary plaque morphology of mild to moderate lesions: an in vivo study using intravascular ultrasound. in Chinese medical journal 2010
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McComb, Shutinoski, Thurston, Cessford, Kumar, Sad: Cathepsins limit macrophage necroptosis through cleavage of Rip1 kinase. in Journal of immunology (Baltimore, Md. : 1950) 2014
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Mouse (Murine) Cathepsin S ELISA Kit for Sandwich ELISA - ABIN415776
Steubl, Kumar, Tato, Mulay, Larsson, Lind, Risérus, Renders, Heemann, Carlsson, Ärnlöv, Anders: Circulating cathepsin-S levels correlate with GFR decline and sTNFR1 and sTNFR2 levels in mice and humans. in Scientific reports 2017
polymorphism of rs7534124 and rs1136774 in cathepsin S promoter may decrease the susceptibility of asthma in a Chinese Han population
cathepsin S mRNA (CTSS), which encodes a cysteine protease (show CTSB ELISA Kits) associated with angiogenesis and atherosclerosis, is highly edited in human endothelial cells. RNA editing enables the recruitment of the stabilizing RNA-binding protein (show PTBP1 ELISA Kits) human antigen R (HuR (show ELAVL1 ELISA Kits); encoded by ELAVL1 (show ELAVL1 ELISA Kits)) to the 3' UTR (show UTS2R ELISA Kits) of the CTSS transcript, thereby controlling CTSS mRNA stability and expression.
levels of cathepsin S and hsCRP observed in women who later developed breast cancer may provide prognostic information regarding tumor development and need to be evaluated in prospective studies.
p41 (show EPB41 ELISA Kits) fragment is also shown to reduce the secretion of interleukin-12 (IL-12 (show IL12A ELISA Kits)/p70 (show ANXA6 ELISA Kits)) during the subsequent maturation of treated dendritic cells.
shedding of surface proteins by extracellular cathepsins impacts intracellular signaling as demonstrated for regulation of Ras GTPase (show RACGAP1 ELISA Kits) activity.
the essential role of autophagy-regulated early ROS (show ROS1 ELISA Kits) in triggering late apoptotic signaling
Cathepsin S cleaves near the N-terminus of PAR2 (show F2RL1 ELISA Kits) to expose a novel tethered ligand, KVDGTS.
Increased plasma CTSS concentration is associated with atherogenesis.
results identify Cat-S as a biased agonist of PAR2 (show F2RL1 ELISA Kits) that causes PAR2 (show F2RL1 ELISA Kits)- and TRPV4 (show TRPV4 ELISA Kits)-dependent inflammation and pain.
Its stability at neutral pH and potent proteolytic activity on extracellular matrix components mean that cathepsin S may contribute significantly to cartilage degradation and may thus be considered a potential drug target in joint diseases.
the roles of CTSB (show CTSB ELISA Kits)/S and SIRT1 (show SIRT1 ELISA Kits) in the regulation of hepatic inflammation using primary parenchymal and non-parenchymal hepatic cell types and cell lines.
Cathepsin S activity controls injury-related vascular remodeling via TLR2 (show TLR2 ELISA Kits)/p38MAPK (show MAPK14 ELISA Kits)/PI3K/Akt (show AKT1 ELISA Kits)/p-HDAC6 (show HDAC6 ELISA Kits) signaling pathway.
Loss of Rab3D (show RAB3D ELISA Kits) from secretory vesicles, leading to disproportionate Rab27 (show RAB27A ELISA Kits)-to-Rab3D (show RAB3D ELISA Kits) activity, may contribute to the enhanced release of cathepsin S in tears of patients with Sjogren's syndrome.
Ctss induction during muscular dystrophy is a pathologic event that partially underlies disease pathogenesis, and its inhibition might serve as a new therapeutic strategy in Duchenne muscular dystrophy (show DMD ELISA Kits).
Demonstrate the utility of intracellular caspase 1 (show CASP1 ELISA Kits) and extracellular CTSS proteolytic activities as surrogate biomarkers of lysosomal rupture and acute inflammation.
Fluorogen substrate, Mca-GRWPPMGLPWE-Lys (show LYZ ELISA Kits)(Dnp)-DArg-NH2 can detect CTSS activities in mouse antigen presenting cells.
Data show that cathepsins S (CatS) regulates CCL2 (show CCL2 ELISA Kits) chemokine (show CCL1 ELISA Kits) expression by modulation of CD74 (show CD74 ELISA Kits) antigen processing.
Cathepsin S activates MrgprC11 (show MRGPRX1 ELISA Kits) and evokes receptor-dependent scratching in mice.
cathepsin S deficiency alters the balance between adipocyte and osteoblast differentiation, increases bone turnover, and changes bone microarchitecture. Therefore, bone and fat metabolisms should be monitored when using cathepsin S inhibitors clinically
These results, together with those previously reported for other genes of this family, suggest that cathepsin genes play a role in defining economically important traits in pigs.
The cathepsin S deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
, cathepsin S, gene 1
, Cathepsin S
, Cat S