Browse our anti-HCK (HCK) Antibodies

Full name:
anti-Hemopoietic Cell Kinase Antibodies (HCK)
On are 146 Hemopoietic Cell Kinase (HCK) Antibodies from 20 different suppliers available. Additionally we are shipping HCK Proteins (16) and HCK Kits (8) and many more products for this protein. A total of 183 HCK products are currently listed.
AI849071, Bmk, HCK, Hctk, JTK9, laloo, MGC107870, p56Hck, p59Hck, p61Hck

Most Popular Reactivities for anti-HCK (HCK) Antibodies

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anti-Human HCK Antibodies:

anti-Mouse (Murine) HCK Antibodies:

anti-Rat (Rattus) HCK Antibodies:

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Top referenced anti-HCK Antibodies

  1. Dog (Canine) Monoclonal HCK Primary Antibody for IF, IP - ABIN967877 : Baumgartner, Angelisová, Setterblad, Mooney, Werling, Horejsí, Langsley: Constitutive exclusion of Csk from Hck-positive membrane microdomains permits Src kinase-dependent proliferation of Theileria-transformed B lymphocytes. in Blood 2003 (PubMed)
    Show all 5 references for 967877

  2. Human Polyclonal HCK Primary Antibody for EIA, WB - ABIN359984 : Komuro, Yokota, Yasuda, Iwamoto, Kagawa: CSF-induced and HIV-1-mediated distinct regulation of Hck and C/EBPbeta represent a heterogeneous susceptibility of monocyte-derived macrophages to M-tropic HIV-1 infection. in The Journal of experimental medicine 2003 (PubMed)
    Show all 4 references for 359984

  3. Human Polyclonal HCK Primary Antibody for FACS, IHC (p) - ABIN652384 : Hassan, Suzu, Hiyoshi, Takahashi-Makise, Ueno, Agatsuma, Akari, Komano, Takebe, Motoyoshi, Okada: Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms. in Journal of cellular physiology 2009 (PubMed)
    Show all 3 references for 652384

  4. Human Polyclonal HCK Primary Antibody for WB - ABIN392099 : Stanglmaier, Warmuth, Kleinlein, Reis, Hallek: The interaction of the Bcr-Abl tyrosine kinase with the Src kinase Hck is mediated by multiple binding domains. in Leukemia 2003 (PubMed)
    Show all 2 references for 392099

  5. Human Polyclonal HCK Primary Antibody for IF, ELISA - ABIN1531606 : Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: The DNA sequence and comparative analysis of human chromosome 20. ... in Nature 2002 (PubMed)
    Show all 2 references for 1531606

  6. Human Monoclonal HCK Primary Antibody for IHC, ELISA - ABIN969187 : Schnoor: What I learned in Europe.... in Environmental science & technology 2007 (PubMed)
    Show all 2 references for 969187

More Antibodies against HCK Interaction Partners

Human Hemopoietic Cell Kinase (HCK) interaction partners

  1. Lysophosphatidylcholines prime polymorphonuclear neutrophil through Hck-dependent activation of PKCdelta (show PKCd Antibodies), which stimulates PKCgamma (show PRKCG Antibodies), resulting in translocation of phosphorylated p47(phox).

  2. HCK represents a novel target for therapeutic development in MYD88 (show MYD88 Antibodies)-mutated Waldenstrom macroglobulinemia and activated-B cell diffuse large B-cell lymphoma, and possibly other diseases driven by mutated MYD88 (show MYD88 Antibodies).

  3. High HCK levels correlate with reduced survival of colorectal cancer patients and is associated with activated macrophages gene signature.

  4. three-dimensional (3D) QSAR pharmacophore models were generated for Hck based on experimentally known inhibitors. A best pharmacophore model, Hypo1, was developed with high correlation coefficient (0.975), Low RMS deviation (0.60) and large cost difference (49.31), containing three ring aromatic and one hydrophobic aliphatic feature

  5. we provide evidence for involvement of HCK and FGR (show FGR Antibodies) in FCRL4 (show FCRL4 Antibodies)-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 (show FCRL4 Antibodies) molecule.

  6. Interaction with the Src (show SRC Antibodies) homology (SH3-SH2) region of the Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitment.

  7. Interaction between Nef and Hck is important for Nef-dependent modulation of viral infectivity.

  8. Data indicate that combined treatment using SFK (LYN (show LYN Antibodies), HCK, or FGR (show FGR Antibodies)) and c-KIT (show KIT Antibodies) inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 (show TP53 Antibodies) activity and enhancing targeting of acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)) stem cells.

  9. The SRC (show SRC Antibodies) family tyrosine kinase (show TXK Antibodies) HCK and the ETS (show ETS1 Antibodies) family transcription factors SPIB (show SPIB Antibodies) and EHF (show EHF Antibodies) regulate transcytosis across a human follicle-associated epithelium model.

  10. This particular binding mode enables Hck SH3 to sense a specific non-canonical residue situated in the SH3 RT-loop of the kinase.

Mouse (Murine) Hemopoietic Cell Kinase (HCK) interaction partners

  1. the Hck, Fgr (show FGR Antibodies) and Lyn (show LYN Antibodies) kinases are also necessary for amastigote uptake by macrophages. Src (show SRC Antibodies)-mediated Arg activation is required for efficient uptake.

  2. Hematopoietic Hck promotes tumorigenesis.

  3. Data suggest that Hck is a key mediator of renal fibrosis

  4. Data indicate that Src (show SRC Antibodies)-Family Kinases Hck and Fgr (show FGR Antibodies) regulate cytokine secretion by macrophages.

  5. Hck is not only progressively overexpressed in atherosclerosis, but it also controls critical molecular processes in monocyte influx, blood monocyte subset balance, macrophage accumulation, and the maintenance of atherosclerotic lesion stability.

  6. The Src (show SRC Antibodies) family kinases Hck, Fgr (show FGR Antibodies), and Lyn (show LYN Antibodies) are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.

  7. tyrosine phosphorylation of WASP (show WASL Antibodies) by Hck is required for proper macrophage functions

  8. Hck is one of the very few effectors of preosteoclast recruitment described to date and thereby plays a critical role in bone remodeling.

  9. Despite possessing enhanced killing, alveolar macrophage Hck/Fgr (show FGR Antibodies)/Lyn (show LYN Antibodies)-deficient ("triple-knockout") mice do not demonstrate enhanced inflammatory responses to Pneumocystis murina.

  10. Taken together, PKR (show EIF2AK2 Antibodies) and Hck were critical for DON-induced ribosomal recruitment of p38 (show CRK Antibodies), its subsequent phosphorylation, and, ultimately, p38 (show CRK Antibodies)-driven proinflammatory cytokine expression.

Cow (Bovine) Hemopoietic Cell Kinase (HCK) interaction partners

  1. A truncated, mRNA-encoded src-related tyrosine kinase (show FRK Antibodies) HCK could function as an adaptor protein or as a competitive inhibitor in spermiogenesis or mature sperm functions.

  2. the presence of mRNAs encoding for hck and hck-tr in testicular germ cells; hck-tr being translated during spermatogenesis and expressed on mature ejaculated bull spermatozoa.

HCK Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon.

Alternative names and synonyms associated with HCK

  • hemopoietic cell kinase (tklal-a) antibody
  • hemopoietic cell kinase (HCK) antibody
  • hemopoietic cell kinase (hck) antibody
  • hemopoietic cell kinase (Hck) antibody
  • AI849071 antibody
  • Bmk antibody
  • HCK antibody
  • Hctk antibody
  • JTK9 antibody
  • laloo antibody
  • MGC107870 antibody
  • p56Hck antibody
  • p59Hck antibody
  • p61Hck antibody

Protein level used designations for HCK

hemopoietic cell kinase , non-receptor protein tyrosine kinase laloo , tyrosine-protein kinase HCK-like , hematopoietic cell kinase , p59-HCK/p60-HCK , tyrosine-protein kinase HCK , B cell/myeloid kinase , B-cell/myeloid kinase , p56-HCK/p59-HCK , hemopoietic cell tyrosine kinase , p56-HCK

373700 Xenopus laevis
458163 Pan troglodytes
485828 Canis lupus familiaris
548439 Xenopus (Silurana) tropicalis
100455620 Pongo abelii
100587780 Nomascus leucogenys
3055 Homo sapiens
15162 Mus musculus
25734 Rattus norvegicus
419280 Gallus gallus
280814 Bos taurus
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