Browse our IFI16 Proteins (IFI16)

On are 7 Interferon, gamma-Inducible Protein 16 (IFI16) Proteins from 6 different suppliers available. Additionally we are shipping IFI16 Antibodies (90) and IFI16 Kits (26) and many more products for this protein. A total of 130 IFI16 products are currently listed.
Ifi16, IFNGIP1, p204, PYHIN2
list all proteins Gene Name GeneID UniProt
Mouse IFI16 IFI16 15951 P15092 , Q08619
IFI16 3428 Q16666

IFI16 Proteins (IFI16) by Origin

More Proteins for IFI16 Interaction Partners

Mouse (Murine) Interferon, gamma-Inducible Protein 16 (IFI16) interaction partners

  1. p204 initiated innate antiviral responses in adipose cells, thereby modulating adipocyte function.

  2. cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection.

  3. The present study demonstrated that mouse Leydig cells had innate antiviral activities in response to viral DNA challenge through p204 activation.

  4. Data indicate that the transient expression of p204 in the early stage is indispensable for adipocyte differentiation. Disruption of p204 expression patterns at this stage leads to irreversible damage in fat formation.

  5. IFI16 exerts in vivo anti-tumoral activity by promoting apoptosis of tumor cells.

  6. This gene product interacts with the Tpr protein, a component of the nuclear pore complex.

  7. expression of p204 is activated by the cardiac Gata4 (show GATA4 Proteins), Nkx2.5 (show NKX2-5 Proteins), and Tbx5 (show TBX5 Proteins) proteins

  8. binding of Id1, Id2, or Id3 protein to the Gata4 and Nkx2.5 proteins inhibits the p204-induced differentiation of P19 cells to myocytes

  9. p204 synergizes with pRb (show PGR Proteins) in the stimulation of Cbfa1 (show RUNX2 Proteins)-dependent gene activation and osteoblast differentiation

  10. Ifi204 is a regulator of monocyte/macrophage differentiation and make possible a connection with other myeloid regulators [review]

Human Interferon, gamma-Inducible Protein 16 (IFI16) interaction partners

  1. this study shows that IFI16 is not essential for the IFN response to human cytomegalovirus infection

  2. findings show that IFI16 rapidly oligomerizes at incoming herpesvirus genomes at the nuclear periphery to transcriptionally repress viral gene expression and limit viral replicative capacity; further demonstrate that IFI16 does not initiate upstream activation of the canonical STING/TBK-1 (show TBK1 Proteins)/IRF3 (show IRF3 Proteins) signaling pathway but is required for downstream antiviral cytokine expression.

  3. The authors observed that a reduced IFI16 expression was associated with a very poor survival in chronic lymphocytic leukemia, but only in cases with ZAP70/CD38 expression.

  4. Findings indicate that expression of the scleroderma autoantigens IFI-16 and CENPs (show APITD1 Proteins), which are associated with severe vascular disease, is increased in vascular progenitors and mature endothelial cells. High level, lineage-enriched expression of autoantigens may explain the striking association between clinical phenotypes and the immune targeting of specific autoantigens.

  5. DDR (show DDR1 Proteins)-induced signaling in cells activates the ATM (show ATM Proteins)-p53 (show TP53 Proteins) and ATM (show ATM Proteins)-IKKalpha (show CHUK Proteins)/beta-interferon (show IFNA Proteins) (IFN)-beta (show IFNB1 Proteins) signaling pathways, thus leading to an induction of the p53 (show TP53 Proteins) and IFN-inducible IFI16 gene

  6. These studies identify H2B as an innate nuclear sensor mediating a novel extra chromosomal function, and reveal that two IFI16 complexes mediate KSHV and HSV-1 genome recognition responses, with recognition by the IFI16-BRCA1-H2B complex resulting in IFN-beta responses and recognition by IFI16-BRCA1 resulting in inflammasome responses.

  7. Overall, these data identify a novel activity of the pUL83/IFI16 interactome involved in the regulation of UL54 gene expression and IFI16 stability during early and late phases of human cytomegalovirus replication.

  8. Together, these results demonstrate that herpes simplex virus 1 promotes the loss of IFI16 through at least two mechanisms: (i) by ICP0-dependent degradation of IFI16 and (ii) by vhs-dependent turnover of IFI16 mRNA.

  9. These results reveal that Kaposi's sarcoma-associated herpesvirus utilizes the innate immune nuclear DNA sensor IFI16 to maintain its latency and repression of lytic transcripts, and a late lytic Kaposi's sarcoma-associated herpesvirus gene product(s) targets IFI16 for degradation during lytic reactivation.

  10. Data show that NOD-like receptor signaling genes NOD2, PYCARD (show PYCARD Proteins), CARD6, and IFI16 are upregulated in psoriatic epidermis.

IFI16 Protein Profile

Protein Summary

This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with IFI16

  • interferon, gamma-inducible protein 16 (IFI16)
  • interferon activated gene 204 (Ifi204)
  • interferon, gamma-inducible protein 16 (Ifi16)
  • Ifi16 protein
  • IFNGIP1 protein
  • p204 protein
  • PYHIN2 protein

Protein level used designations for IFI16

interferon, gamma-inducible protein 16 , ifi-204 , interferon, gamma-inducible gene 204 , interferon-activable protein 204 , interferon-inducible protein p204 , gamma-interferon-inducible protein 16 , interferon-gamma induced protein IFI 16 , interferon-inducible myeloid differentiation transcriptional activator , interferon activated gene 203 , Gamma-interferon-inducible protein Ifi-16 , ifi-16

457424 Pan troglodytes
100607897 Nomascus leucogenys
15951 Mus musculus
3428 Homo sapiens
100718476 Cavia porcellus
100156073 Sus scrofa
100172051 Pongo abelii
506759 Bos taurus
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