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The authors demonstrate that HIV and specifically Nef and/or Vpu do not modulate CD155 (show PVR Proteins) on infected primary T cells and both CD155 (show PVR Proteins) and NKG2D ligands synergize as a natural killer cell receptor to trigger natural killer cell lysis of the infected cell.
Utilizing assays measuring cytolysis, the authors provide the first data implicating NKG2D in antibody-dependent NK cell responses against a target cell line either pulsed with gp120 (show ITIH4 Proteins) or infected with HIV-1.
tumoral NKG2D stimulates cell propagation and immune escape in acute myeloid leukemia (show BCL11A Proteins) cells
Data show that anti-VEGFR2 (vascular endothelial growth factor receptor 2 (show KDR Proteins)) antibody (mAb04) of fusion protein (mAb04-MICA (show MICA Proteins)) enhanced immunosurveillance activated by the NKG2D pathway.
these results demonstrate that NKG2D signaling is critical for maximal TNF-alpha (show TNF Proteins) release by NK cells
this study shows that CD20 (show MS4A1 Proteins)-specific immunoligands engaging NKG2D enhance gammadelta T cell-mediated lysis of lymphoma cells
High NKG2D expression is associated with gastric cancer.
Supporting a role for NKG2D ligand expression in controlling the progression of early-stage B cell lymphomas in humans, we found higher expression of a microRNA that inhibits human NKG2D ligand expression in tumor cells from high-grade compared with low-grade follicular lymphoma patients.
On-treatment decrease of NKG2D correlates to early emergence of clinically evident hepatocellular carcinoma after interferon (show IFNA Proteins)-free therapy for chronic hepatitis C
The interaction of Fas receptor (show FAS Proteins) with FasL (show FASL Proteins) leads to an activation of the Tag7 (show PGLYRP1 Proteins)-Hsp70 (show HSP70 Proteins) complex in the lymphocyte membrane fraction, and here FasL (show FASL Proteins) acts as a receptor that induces intracellular signaling in lymphocytes.An interaction of the MicA (show MICA Proteins) stress ligand with the NKG2D receptor is necessary for the release of this cytotoxic complex
The authors observed that the mouse cytomegalovirus encoded protein m18 is necessary and sufficient to drive expression of the RAE-1 (show RAE1 Proteins) family of NKG2D ligands. RAE-1 (show RAE1 Proteins) is transcriptionally repressed by histone deacetylase (show HDAC1 Proteins) inhibitor 3 (show PPP1R11 Proteins) (HDAC3 (show HDAC3 Proteins)) in healthy cells, and m18 relieves this repression by directly interacting with Casein Kinase II (show CSNK2A1 Proteins) and preventing it from activating HDAC3 (show HDAC3 Proteins).
proposed that TLR9 (show TLR9 Proteins) regulates the NF-kappaB (show NFKB1 Proteins)-NLRP3 (show NLRP3 Proteins)-IL-1beta (show IL1B Proteins) pathway negatively in Salmonella-induced NKG2D-mediated intestinal inflammation and plays a critical role in defense against S. typhimurium infection and in the protection of intestinal integrity.
NKG2D-deficient mice and mice constitutively expressing NKG2D ligands had increased incidence of B cell tumors, confirming that the inability to clear NKG2D ligand-expressing cells was important in tumor suppression and that NKG2D ligand expression is a marker of nascent tumors
data show that NKG2D has a nonredundant role in priming of CD8 (show CD8A Proteins)(+) T cells to produce antiviral cytokines
NKG2D augments Ly49H-dependent proliferation of NK cells; however, NKG2D signaling alone is inadequate for expansion of NK cells, likely due to only transient expression of the NKG2D-DAP12 (show TYROBP Proteins) complex
The elevated cytotoxicity achieved by suppressing mTOR (show FRAP1 Proteins) was a result of up-regulation of NKG2D and TNF-alpha (show TNF Proteins). The inhibition of STAT5 (show STAT5A Proteins) pathways via siRNA interference or a specific inhibitor eliminated the up-regulation of NKG2D and TNF-alpha (show TNF Proteins) in rapamycin-treated Vgamma4 gammadelta T cells.
study demonstrates that the effect of NKG2D on B1a cell development occurs at a developmental stage that precedes the common lymphoid progenitor; findings reveal an unexpected new role for NKG2D in the regulation of B1a cell development
Sirt6 (show SIRT6 Proteins) binds to promoters of NKG2D ligand genes and regulates the H3K9 and H3K56 acetylation levels
These results support the conclusion that svH1C mimics Neu5Ac-containing sequences and interacts with cell-surface receptor NKG2D, which contains a lectin-like domain
The effect of Bacillus cereus on the stress response of enterocytes, including the expression of NKG2D, is reported.
Determined expressions of NKG2D in decidual natural killer cells in patients having spontaneous abortions.
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
killer cell lectin-like receptor subfamily K, member 1
, NKG2-D type II integral membrane protein-like
, NK cell receptor D
, NKG2-D type II integral membrane protein
, NKG2-D-activating NK receptor
, natural killer cell group 2D
, NK lectin-like receptor
, NKR-P2, ortholog of human NKG2D
, killer cell lectin-like receptor subfamily K member 1
, NKG2-D activating NK receptor