Browse our Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Proteins (KLRK1)

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Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Proteins (KLRK1)
On www.antibodies-online.com are 21 Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) Proteins from 8 different suppliers available. Additionally we are shipping Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Antibodies (202) and Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Kits (3) and many more products for this protein. A total of 234 Killer Cell Lectin-Like Receptor Subfamily K, Member 1 products are currently listed.
Synonyms:
CD314, D6H12S2489E, D12S2489E, KLR, KLRK1, NKG2-D, Nkg2d, Nkrp2
list all proteins Gene Name GeneID UniProt
KLRK1 22914 P26718
KLRK1 27007 O54709
KLRK1 24934 O70215

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Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Proteins (KLRK1) by Origin

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Top referenced Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Proteins

  1. Human KLRK1 Protein expressed in Escherichia coli (E. coli) - ABIN1098706 : Guerra, Tan, Joncker, Choy, Gallardo, Xiong, Knoblaugh, Cado, Greenberg, Greenberg, Raulet: NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. in Immunity 2008 (PubMed)
    Show all 2 references for 1098706

  2. Human KLRK1 Protein expressed in CHO Cells - ABIN2003085 : Houchins, Yabe, McSherry, Bach: DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. in The Journal of experimental medicine 1991 (PubMed)

More Proteins for Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Interaction Partners

Human Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) interaction partners

  1. non-virally infected human T cells can express NKG2DL, with implications for stress surveillance by the large number of NKG2D-expressing NK cells sequestered in the liver.

  2. After PSK (show TAOK2 Proteins) administration, INF (show GIF Proteins)-g production in CD8 (show CD8A Proteins)(+) T cells increased in mice with cells expressing neither Rae-1 (show RAE1 Proteins) nor H60, but did not change in mice implanted with cells expressing both Rae-1 (show RAE1 Proteins) and H60. We demonstrated that the expression of NKG2DLs affects tumor immunity and the efficacy of immuno therapy in tumor-bearing mouse model

  3. These results suggest the involvement of HIV-1 nef and human NKG2D-NKG2D ligand interactions in the enhanced susceptibility of HIV-1-infected cells from HIV elite controllers to antibody-dependent cellular cytotoxicity responses.

  4. Blocking the interaction of NKG2D with its ligands deleted the sensitizing effects of HCQ. In addition, we showed that HCQ did not affect the synthesis or degradation of ULBP4 (show RAET1E Proteins), but induced the translocation of ULBP4 (show RAET1E Proteins) from the cytoplasm to the cell membrane

  5. High NKG2D expression is associated with hepatocellular carcinoma.

  6. In the second trimester, functional markers of Decidual natural killer activation, i.e., angiogenic factor (show VEGFA Proteins) production (e.g., vascular endothelial growth factor, interleukin-8 (show IL8 Proteins), interferon-gamma (show IFNG Proteins)), remained stable despite an increase in NKp80 (show KLRF1 Proteins) or NKG2D surface expression.

  7. Our data showed that NKG2D receptor could be an independent favorable prognostic indicator for gastric cancer. Furthermore, decreased NKG2D expression might be the mechanism underlying immune evasion by tumors in gastric cancer.

  8. The NKG2D gene polymorphisms may modify the risk of development and severity of RA.

  9. our results support and explain the mechanism behind the recently reported finding that in EOC, NK-cell recognition and killing of tumor cells was mainly dependent on DNAM-1 (show CD226 Proteins) signaling while the contribution of the NKG2D receptor-ligand pathway was complementary and uncertain.

  10. MicroRNA-30c promotes natural killer cell cytotoxicity via up-regulating the expression level of NKG2D

Mouse (Murine) Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) interaction partners

  1. Sirt6 (show SIRT6 Proteins) binds to promoters of NKG2D ligand genes and regulates the H3K9 and H3K56 acetylation levels

  2. These results support the conclusion that svH1C mimics Neu5Ac-containing sequences and interacts with cell-surface receptor NKG2D, which contains a lectin-like domain

  3. These results indicate that, unlike in the pancreas, NKG2D-NKG2D ligand interaction does not play a critical role in obesity-induced inflammation in the adipose tissue.

  4. The results show that NK cells and the NKG2D receptor play a role in control of lymphomas, and that selection of NKG2D-ligand (MULT1 (show ULBP1 Proteins)) loss mutants provides a mechanism for tumor escape.

  5. these data support a novel role for NKG2D expression by CD8 (show CD8A Proteins)(+) T cells during allogeneic HSCT, which could be potentially therapeutically exploited to separate GVHD from GVT effects.

  6. NKG2D and NKG2DL are involved in allergen-induced activation of dendritic epidermal T cells and the NKG2D/NKG2DL pathway might be a potential target for treatment of contact hypersensitivity.

  7. Viral infection of cultured cells increased RAE-1 (show RAE1 Proteins) expression, resulting in enhanced NK cell-mediated killing through NKG2D recognition.

  8. Activation through the NKG2D receptor leads to the differential activation of the NF-kappaB (show NFKB1 Proteins) signaling pathway and potentially enhances the anti-tumor and anti-viral functions of effector CD8 (show CD8A Proteins)(+) T cells.

  9. Desiccating stress-induced chemokine (show CCL1 Proteins) expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 (show RAE1 Proteins) and release of IFN-gamma (show IFNG Proteins) in experimental dry eye.

  10. Highly target-specific liver NKT (show CTSL1 Proteins) cells selectively remove activated hepatic stellate cells through an NKG2D-Rae1 (show RAE1 Proteins) interaction to ameliorate liver fibrosis after IL-30 treatment.

Pig (Porcine) Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) interaction partners

  1. The effect of Bacillus cereus on the stress response of enterocytes, including the expression of NKG2D, is reported.

Rhesus Monkey Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) interaction partners

  1. Determined expressions of NKG2D in decidual natural killer cells in patients having spontaneous abortions.

Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) Protein Profile

Protein Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.

Alternative names and synonyms associated with Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1)

  • killer cell lectin-like receptor subfamily K, member 1 (KLRK1)
  • NKG2-D type II integral membrane protein-like (LOC100398970)
  • killer cell lectin-like receptor subfamily K, member 1 (Klrk1)
  • NKG2D protein (NKG2D)
  • CD314 protein
  • D6H12S2489E protein
  • D12S2489E protein
  • KLR protein
  • KLRK1 protein
  • NKG2-D protein
  • Nkg2d protein
  • Nkrp2 protein

Protein level used designations for KLRK1

killer cell lectin-like receptor subfamily K, member 1 , NKG2-D type II integral membrane protein-like , NK cell receptor D , NKG2-D type II integral membrane protein , NKG2-D-activating NK receptor , natural killer cell group 2D , NK lectin-like receptor , NKLLR , NKR-P2, ortholog of human NKG2D , killer cell lectin-like receptor subfamily K member 1 , NKG2-D activating NK receptor

GENE ID SPECIES
611355 Canis lupus familiaris
100126736 Papio anubis
100398970 Callithrix jacchus
22914 Homo sapiens
27007 Mus musculus
24934 Rattus norvegicus
396737 Sus scrofa
450153 Pan troglodytes
574240 Macaca mulatta
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