Browse our MAVS Proteins (MAVS)

Full name:
Mitochondrial Antiviral Signaling Protein Proteins (MAVS)
On are 8 Mitochondrial Antiviral Signaling Protein (MAVS) Proteins from 4 different suppliers available. Additionally we are shipping MAVS Antibodies (191) and MAVS Kits (8) and many more products for this protein. A total of 217 MAVS products are currently listed.
cardif, D430028G21Rik, HISPPD2A, hsVIP1, IP6K, IPS-1, IPS1, VIP1, Visa
list all proteins Gene Name GeneID UniProt
MAVS 9677 Q6PFW1
MAVS 228607 Q8VCF0
Rat MAVS MAVS 311430 Q66HG9

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MAVS Proteins (MAVS) by Origin

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Top referenced MAVS Proteins

  1. Human MAVS Protein expressed in Escherichia coli (E. coli) - ABIN1098533 : Seth, Sun, Ea, Chen: Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. in Cell 2005 (PubMed)
    Show all 2 references for 1098533

  2. Human MAVS Protein expressed in HEK-293 Cells - ABIN2725562 : He, Zhu, Wen, Yuan, Hu, Chen, An, Dong, Lin, Yu, Wu, Yang, Cai, Li, Li: Dengue Virus Subverts Host Innate Immunity by Targeting Adaptor Protein MAVS. in Journal of virology 2016 (PubMed)

More Proteins for MAVS Interaction Partners

Pig (Porcine) Mitochondrial Antiviral Signaling Protein (MAVS) interaction partners

  1. The authors determined that porcine reproductive and respiratory syndrome virus 3C protease cleaved MAVS at Glu268.

  2. Real-time quantitative PCR analysis indicated that Tibetan porcine IPS-1 (show ISYNA1 Proteins) mRNA was most abundant in the liver and kidney.

Human Mitochondrial Antiviral Signaling Protein (MAVS) interaction partners

  1. Mechanistic studies showed that HACE1 (show HACE1 Proteins) exerts its inhibitory role on virus-induced signaling by disrupting the MAVS-TRAF3 (show TRAF3 Proteins) complex.

  2. this study shows that keratinocytes are an important source of IFN-beta (show IFNB1 Proteins) and MAVS is critical to this function, and demonstrates how the epidermis triggers unwanted skin inflammation under disease conditions

  3. Herpes simplex virus 1 blocks MAVS-Pex (show PHEX Proteins) mediated early interferon (show IFNA Proteins)-stimulated gene activation through VP16 to dampen the immediate early (show JUN Proteins) antiviral innate immunity signaling from peroxisomes.

  4. This study demonstrates a novel pathway for elevated IFNbeta signaling in SLE that is not dependent on stimulation by immune complexes but rather is cell intrinsic and critically mediated by IFNbeta and MAVS.

  5. TTLL12 as a negative regulator of RNA-virus-induced type I IFN expression by inhibiting the interaction of VISA with other proteins.

  6. Therefore, Seneca Valley virus suppressed antiviral interferon (show IFNA Proteins) production to escape host antiviral innate immune responses by cleaving host adaptor molecules MAVS, TRIF (show TRIM69 Proteins), and TANK by its 3C protease.

  7. GPATCH3 interacts with VISA and disrupts the assembly of virus-induced VISA signalosome therefore acts as a negative regulator of RLR (show DHX58 Proteins)-mediated innate antiviral immune responses.

  8. this study shows that MAVS silencing upregulates IFN-beta (show IFNB1 Proteins) production via upregulation of NF-kappaB (show NFKB1 Proteins) and IRF3 (show IRF3 Proteins) signaling

  9. DDX3 (show DDX3X Proteins) directly regulates TRAF3 (show TRAF3 Proteins) ubiquitination and acts as a scaffold to co-ordinate assembly of signaling complexes downstream from MAVS.

  10. this study identified three single nucleotide polymorphisms within MAVS that showed significant differences in plasma HIV-1 viral load

Mouse (Murine) Mitochondrial Antiviral Signaling Protein (MAVS) interaction partners

  1. this study shows that keratinocytes are an important source of IFN-beta (show IFNB1 Proteins) and MAVS is critical to this function, and demonstrates how the epidermis triggers unwanted skin inflammation under disease conditions

  2. RIPK3 (show RIPK3 Proteins) regulates type I IFN both transcriptionally, by interacting with MAVS and limiting RIPK1 (show RIPK1 Proteins) interaction with MAVS, and post-transcriptionally.

  3. Data suggest that activation of either RIG-I (show DDX58 Proteins)/MAVS or STING pathways during acute intestinal tissue injury in mice resulted in IFN-I signaling that maintained gut (show GUSB Proteins) epithelial barrier integrity and reduced GVHD severity.

  4. this paper identifies TRIM31 (show TRIM31 Proteins), an E3 ubiquitin ligase (show MUL1 Proteins) of the TRIM (show TRAT1 Proteins) family of proteins, as a regulator of MAVS aggregation

  5. Taken together, these results suggest that MAVS is essential for boosting optimal primary CD4 (show CD4 Proteins)(+) T cell responses upon NS4B-P38G West Nile virus vaccination and yet is dispensable for host protection and recall T cell responses during secondary wild-type West Nile virus infection.

  6. this study demonstrates that the capacity of hepatitis A virus to evade MAVS-mediated type I interferon (show IFNA Proteins) responses defines its host species range.

  7. Hepatitis C virus NS3-4A inhibits the peroxisomal MAVS-dependent antiviral signaling response.

  8. Rotavirus infection in macrophages depend on MAVS but not involve the NLRP3 (show NLRP3 Proteins) inflammasome nor JNK (show MAPK8 Proteins) and p38 (show CRK Proteins) signal pathway.

  9. MARCH5 (show MARCH5 Proteins) binds MAVS only during viral stimulation when MAVS forms aggregates, and these interactions require the RING domain of MARCH5 (show MARCH5 Proteins) and the CARD domain of MAVS.

  10. An autoinhibitory mechanism modulates MAVS activity in unstimulated cells and, on viral infection, individual regions of MAVS are released following MAVS filament formation to activate antiviral signalling cascades.

MAVS Protein Profile

Protein Summary

This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with MAVS

  • mitochondrial antiviral signaling protein (MAVS)
  • diphosphoinositol pentakisphosphate kinase 1 (PPIP5K1)
  • mitochondrial antiviral signaling protein (Mavs)
  • cardif protein
  • D430028G21Rik protein
  • HISPPD2A protein
  • hsVIP1 protein
  • IP6K protein
  • IPS-1 protein
  • IPS1 protein
  • VIP1 protein
  • Visa protein

Protein level used designations for MAVS

virus-induced signaling adapter , mitochondrial antiviral-signaling protein , mitochondrial IFN-beta promoter stimulator 1 , IP6 kinase , VIP1 homolog , histidine acid phosphatase domain containing 2A , histidine acid phosphatase domain-containing protein 2A , inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 , inositol pyrophosphate synthase 1 , insP6 and PP-IP5 kinase 1 , CARD adapter inducing interferon beta , CARD adaptor inducing IFN-beta , IFN-B promoter stimulator 1 , interferon beta promoter stimulator protein 1 , putative NF-kappa-B-activating protein 031N , virus-induced signaling adaptor , virus-induced-signaling adapter , IFN-beta promoter stimulator-1 , mitochondrial anti-viral signaling protein , IPS-1 , interferon-beta promoter stimulator protein 1

470026 Pan troglodytes
485789 Canis lupus familiaris
717616 Macaca mulatta
100037290 Sus scrofa
9677 Homo sapiens
57506 Homo sapiens
228607 Mus musculus
311430 Rattus norvegicus
618508 Bos taurus
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