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Browse our NLRC4 (NLRC4) ELISA Kits

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NLR Family, CARD Domain Containing 4 ELISA Kits (NLRC4)
On www.antibodies-online.com are 10 NLR Family, CARD Domain Containing 4 (NLRC4) ELISA Kits from 5 different suppliers available. Additionally we are shipping NLRC4 Antibodies (98) and NLRC4 Proteins (3) and many more products for this protein. A total of 116 NLRC4 products are currently listed.
Synonyms:
9530011P19Rik, Card12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, IPAF
list all ELISA KIts Gene Name GeneID UniProt
NLRC4 58484 Q9NPP4
NLRC4 268973  
NLRC4 298784  

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NLRC4 (NLRC4) ELISA Kits by Reactivity

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Human NLR Family, CARD Domain Containing 4 (NLRC4) interaction partners

  1. LPS (show IRF6 ELISA Kits) activates the MAPK (show MAPK1 ELISA Kits) pathway in macrophages, thus resulting in the upregulation of NLRC4; however, NLRC4 inhibits IL1beta (show IL1B ELISA Kits) and IL18 (show IL18 ELISA Kits) production, contributing to the anti-inflammatory response.

  2. High expression of NLRP3 (show NLRP3 ELISA Kits), NLRC4, and CASP1 (show CASP1 ELISA Kits) in background non-tumorous liver is significantly correlated with poor prognosis of patients after resection of hepatocellular carcinoma.

  3. association of IL-18 (show IL18 ELISA Kits) levels with a single nucleotide polymorphism in the untranslated exon 2 of the inflammasome component NLRC4

  4. While both contributing to pathogen clearance, NLRP3 (show NLRP3 ELISA Kits) more than NLRC4 contributes to deleterious inflammatory responses in cystic fibrosis (show S100A8 ELISA Kits) and correlates with defective NLRC4-dependent IL-1Ra (show IL1RN ELISA Kits) production.

  5. analysis of a subset of inflammasome receptors including NLRP3 (show NLRP3 ELISA Kits), NLRC4 and AIM2 (show AIM2 ELISA Kits) that triggers formation of the micrometer-sized spherical supramolecular complex called the ASC (show PYCARD ELISA Kits) speck

  6. Thus, pathogenic inflammasome activity during Candida infection is negatively regulated by the IL-22 (show IL22 ELISA Kits)/NLRC4/IL-1Ra (show IL1RN ELISA Kits) axis.

  7. cN-II (show NT5C2 ELISA Kits) co-immunoprecipitated both with wild type Ipaf and its LRR domain after transfection with corresponding expression vectors, but not with Ipaf lacking the LRR domain.

  8. Elevated expression of IPAF was associated with inflammation in patients with pemphigus vulgaris (show DSG3 ELISA Kits) disease.

  9. Data indicate that NLR family CARD domain containing 4 protein (NLRC4) is a causative gene for familial cold autoinflammatory syndrome (FCAS).

  10. Data show that the disease was caused by a de novo gain-of-function mutation in NLR family CARD domain containing 4 (NLRC4) encoding a p.Val341Ala substitution.

Mouse (Murine) NLR Family, CARD Domain Containing 4 (NLRC4) interaction partners

  1. LPS (show TLR4 ELISA Kits) activates the MAPK (show MAPK1 ELISA Kits) pathway in macrophages, thus resulting in the upregulation of NLRC4; however, NLRC4 inhibits IL1beta (show IL1B ELISA Kits) and IL18 (show IL18 ELISA Kits) production, contributing to the anti-inflammatory response.

  2. These data reveal mild constitutive activation of the Nlrc4 inflammasome as the results of two SNPs, which leads to the stimulation of hepatocyte proliferation. The increased liver regeneration induces rapid liver mass recovery after hepatectomy and may prevent the development of hepatotoxin-induced liver fibrosis.

  3. While both contributing to pathogen clearance, NLRP3 (show NLRP3 ELISA Kits) more than NLRC4 contributes to deleterious inflammatory responses in cystic fibrosis (show S100A8 ELISA Kits) and correlates with defective NLRC4-dependent IL-1Ra (show IL1RN ELISA Kits) production.

  4. The wheel-like structure of a PrgJ-NAIP2-NLRC4 complex determined by cryogenic electronmicroscopy at 6.6 angstrom reveals that NLRC4 activation involves substantial structural reorganization that creates one oligomerization surface (catalytic surface).

  5. caspase-1 (show CASP1 ELISA Kits) is activated in macrophages under hypertonic conditions through NLRP3 (show NLRP3 ELISA Kits) and NLRC4 inflammasome activation.

  6. These results show that NLRC4 and TLR5 (show TLR5 ELISA Kits), key components of two flagellin (show FliC ELISA Kits) sensing pathways, each contribute to host defense in respiratory melioidosis.

  7. Data show that caspase-1 (show CASP1 ELISA Kits) but not caspase-11 (show CASP4 ELISA Kits) was essential for the functional activities of the NLRC4 inflammasome.

  8. TLR4 (show TLR4 ELISA Kits) activation induces IL-1beta (show IL1B ELISA Kits) release via an IPAF dependent but caspase 1 (show CASP1 ELISA Kits)/11/8 independent pathway in the lung.

  9. The present findings demonstrated that mice deficient in NLRC4 or ASC (show STS ELISA Kits), but not in NLRP3 (show NLRP3 ELISA Kits), present reduced mechanical and thermal acute inflammatory hyperalgesia induced by carrageenan

  10. AIM2 (show AIM2 ELISA Kits) and NLRC4 inflammasomes contribute with ASC (show STS ELISA Kits) to acute brain injury independently of NLRP3 (show NLRP3 ELISA Kits)

NLRC4 Antigen Profile

Antigen Summary

In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.

Alternative names and synonyms associated with NLRC4

  • NLR family, CARD domain containing 4 (NLRC4) Elisa Kit
  • NLR family, CARD domain containing 4 (Nlrc4) Elisa Kit
  • 9530011P19Rik Elisa Kit
  • Card12 Elisa Kit
  • CLAN Elisa Kit
  • CLAN1 Elisa Kit
  • CLANA Elisa Kit
  • CLANB Elisa Kit
  • CLANC Elisa Kit
  • CLAND Elisa Kit
  • CLR2.1 Elisa Kit
  • IPAF Elisa Kit

Protein level used designations for NLRC4

caspase recruitment domain protein 12 , NLR family CARD domain-containing protein 4 , ice protease-activating factor , ipaf , NLR family, CARD domain containing 4 , CARD, LRR, and NACHT-containing protein , ICE-protease activating factor , NOD-like receptor C4 , caspase recruitment domain family, member 12 , caspase recruitment domain-containing protein 12 , nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4

GENE ID SPECIES
459135 Pan troglodytes
512480 Bos taurus
706378 Macaca mulatta
100070605 Equus caballus
58484 Homo sapiens
268973 Mus musculus
298784 Rattus norvegicus
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