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Browse our NLRC4 Proteins (NLRC4)

Full name:
NLR Family, CARD Domain Containing 4 Proteins (NLRC4)
On www.antibodies-online.com are 3 NLR Family, CARD Domain Containing 4 (NLRC4) Proteins from 2 different suppliers available. Additionally we are shipping NLRC4 Antibodies (98) and NLRC4 Kits (11) and many more products for this protein. A total of 117 NLRC4 products are currently listed.
Synonyms:
9530011P19Rik, Card12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, IPAF
list all proteins Gene Name GeneID UniProt
NLRC4 58484 Q9NPP4
NLRC4 268973  
Rat NLRC4 NLRC4 298784  

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NLRC4 Proteins (NLRC4) by Origin

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More Proteins for NLRC4 Interaction Partners

Human NLR Family, CARD Domain Containing 4 (NLRC4) interaction partners

  1. LPS (show IRF6 Proteins) activates the MAPK (show MAPK1 Proteins) pathway in macrophages, thus resulting in the upregulation of NLRC4; however, NLRC4 inhibits IL1beta (show IL1B Proteins) and IL18 (show IL18 Proteins) production, contributing to the anti-inflammatory response.

  2. High expression of NLRP3 (show NLRP3 Proteins), NLRC4, and CASP1 (show CASP1 Proteins) in background non-tumorous liver is significantly correlated with poor prognosis of patients after resection of hepatocellular carcinoma.

  3. association of IL-18 (show IL18 Proteins) levels with a single nucleotide polymorphism in the untranslated exon 2 of the inflammasome component NLRC4

  4. While both contributing to pathogen clearance, NLRP3 (show NLRP3 Proteins) more than NLRC4 contributes to deleterious inflammatory responses in cystic fibrosis (show S100A8 Proteins) and correlates with defective NLRC4-dependent IL-1Ra (show IL1RN Proteins) production.

  5. analysis of a subset of inflammasome receptors including NLRP3 (show NLRP3 Proteins), NLRC4 and AIM2 (show AIM2 Proteins) that triggers formation of the micrometer-sized spherical supramolecular complex called the ASC (show PYCARD Proteins) speck

  6. Thus, pathogenic inflammasome activity during Candida infection is negatively regulated by the IL-22 (show IL22 Proteins)/NLRC4/IL-1Ra (show IL1RN Proteins) axis.

  7. cN-II (show NT5C2 Proteins) co-immunoprecipitated both with wild type Ipaf and its LRR domain after transfection with corresponding expression vectors, but not with Ipaf lacking the LRR domain.

  8. Elevated expression of IPAF was associated with inflammation in patients with pemphigus vulgaris (show DSG3 Proteins) disease.

  9. Data indicate that NLR family CARD domain containing 4 protein (NLRC4) is a causative gene for familial cold autoinflammatory syndrome (FCAS).

  10. Data show that the disease was caused by a de novo gain-of-function mutation in NLR family CARD domain containing 4 (NLRC4) encoding a p.Val341Ala substitution.

Mouse (Murine) NLR Family, CARD Domain Containing 4 (NLRC4) interaction partners

  1. LPS (show TLR4 Proteins) activates the MAPK (show MAPK1 Proteins) pathway in macrophages, thus resulting in the upregulation of NLRC4; however, NLRC4 inhibits IL1beta (show IL1B Proteins) and IL18 (show IL18 Proteins) production, contributing to the anti-inflammatory response.

  2. These data reveal mild constitutive activation of the Nlrc4 inflammasome as the results of two SNPs, which leads to the stimulation of hepatocyte proliferation. The increased liver regeneration induces rapid liver mass recovery after hepatectomy and may prevent the development of hepatotoxin-induced liver fibrosis.

  3. While both contributing to pathogen clearance, NLRP3 (show NLRP3 Proteins) more than NLRC4 contributes to deleterious inflammatory responses in cystic fibrosis (show S100A8 Proteins) and correlates with defective NLRC4-dependent IL-1Ra (show IL1RN Proteins) production.

  4. The wheel-like structure of a PrgJ-NAIP2-NLRC4 complex determined by cryogenic electronmicroscopy at 6.6 angstrom reveals that NLRC4 activation involves substantial structural reorganization that creates one oligomerization surface (catalytic surface).

  5. caspase-1 (show CASP1 Proteins) is activated in macrophages under hypertonic conditions through NLRP3 (show NLRP3 Proteins) and NLRC4 inflammasome activation.

  6. These results show that NLRC4 and TLR5 (show TLR5 Proteins), key components of two flagellin (show FliC Proteins) sensing pathways, each contribute to host defense in respiratory melioidosis.

  7. Data show that caspase-1 (show CASP1 Proteins) but not caspase-11 (show CASP4 Proteins) was essential for the functional activities of the NLRC4 inflammasome.

  8. TLR4 (show TLR4 Proteins) activation induces IL-1beta (show IL1B Proteins) release via an IPAF dependent but caspase 1 (show CASP1 Proteins)/11/8 independent pathway in the lung.

  9. The present findings demonstrated that mice deficient in NLRC4 or ASC (show STS Proteins), but not in NLRP3 (show NLRP3 Proteins), present reduced mechanical and thermal acute inflammatory hyperalgesia induced by carrageenan

  10. AIM2 (show AIM2 Proteins) and NLRC4 inflammasomes contribute with ASC (show STS Proteins) to acute brain injury independently of NLRP3 (show NLRP3 Proteins)

NLRC4 Protein Profile

Protein Summary

In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.

Alternative names and synonyms associated with NLRC4

  • NLR family, CARD domain containing 4 (NLRC4)
  • NLR family, CARD domain containing 4 (Nlrc4)
  • 9530011P19Rik protein
  • Card12 protein
  • CLAN protein
  • CLAN1 protein
  • CLANA protein
  • CLANB protein
  • CLANC protein
  • CLAND protein
  • CLR2.1 protein
  • IPAF protein

Protein level used designations for NLRC4

caspase recruitment domain protein 12 , NLR family CARD domain-containing protein 4 , ice protease-activating factor , ipaf , NLR family, CARD domain containing 4 , CARD, LRR, and NACHT-containing protein , ICE-protease activating factor , NOD-like receptor C4 , caspase recruitment domain family, member 12 , caspase recruitment domain-containing protein 12 , nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4

GENE ID SPECIES
459135 Pan troglodytes
512480 Bos taurus
706378 Macaca mulatta
100070605 Equus caballus
58484 Homo sapiens
268973 Mus musculus
298784 Rattus norvegicus
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