Browse our NLRC4 Proteins (NLRC4)

Full name:
NLR Family, CARD Domain Containing 4 Proteins (NLRC4)
On www.antibodies-online.com are 3 NLR Family, CARD Domain Containing 4 (NLRC4) Proteins from 2 different suppliers available. Additionally we are shipping NLRC4 Antibodies (95) and NLRC4 Kits (13) and many more products for this protein. A total of 116 NLRC4 products are currently listed.
Synonyms:
9530011P19Rik, Card12, CLAN, CLAN1, CLANA, CLANB, CLANC, CLAND, CLR2.1, IPAF
list all proteins Gene Name GeneID UniProt
NLRC4 58484 Q9NPP4
NLRC4 268973  
Rat NLRC4 NLRC4 298784  

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NLRC4 Proteins (NLRC4) by Origin

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More Proteins for NLRC4 Interaction Partners

Human NLR Family, CARD Domain Containing 4 (NLRC4) interaction partners

  1. Results found that NLRC4 expression increased in for promoting DN progression and demonstrate NLRC4-driven IL-1beta (show IL1B Proteins) production as critical for the progression of DN.

  2. Ubiquitin-tagged NLRC4 could induce cell death and activate caspase-8 (show CASP8 Proteins) independent of Ser (show SIGLEC1 Proteins)(533) phosphorylation. Our

  3. LPS (show IRF6 Proteins) activates the MAPK (show MAPK1 Proteins) pathway in macrophages, thus resulting in the upregulation of NLRC4; however, NLRC4 inhibits IL1beta (show IL1B Proteins) and IL18 (show IL18 Proteins) production, contributing to the anti-inflammatory response.

  4. High expression of NLRP3 (show NLRP3 Proteins), NLRC4, and CASP1 (show CASP1 Proteins) in background non-tumorous liver is significantly correlated with poor prognosis of patients after resection of hepatocellular carcinoma.

  5. association of IL-18 (show IL18 Proteins) levels with a single nucleotide polymorphism in the untranslated exon 2 of the inflammasome component NLRC4

  6. While both contributing to pathogen clearance, NLRP3 (show NLRP3 Proteins) more than NLRC4 contributes to deleterious inflammatory responses in cystic fibrosis (show S100A8 Proteins) and correlates with defective NLRC4-dependent IL-1Ra (show IL1RN Proteins) production.

  7. analysis of a subset of inflammasome receptors including NLRP3 (show NLRP3 Proteins), NLRC4 and AIM2 (show AIM2 Proteins) that triggers formation of the micrometer-sized spherical supramolecular complex called the ASC (show PYCARD Proteins) speck

  8. Thus, pathogenic inflammasome activity during Candida infection is negatively regulated by the IL-22 (show IL22 Proteins)/NLRC4/IL-1Ra (show IL1RN Proteins) axis.

  9. cN-II (show NT5C2 Proteins) co-immunoprecipitated both with wild type Ipaf and its LRR domain after transfection with corresponding expression vectors, but not with Ipaf lacking the LRR domain.

  10. Elevated expression of IPAF was associated with inflammation in patients with pemphigus vulgaris (show DSG3 Proteins) disease.

Mouse (Murine) NLR Family, CARD Domain Containing 4 (NLRC4) interaction partners

  1. NLRC4 expression controls melanoma tumor growth.

  2. The interplay between NLRP3 (show NLRP3 Proteins) and NLRC4 reveals an unexpected overlap between what had been considered distinct inflammasome scaffolds.

  3. The activation of NLRC4 by flagellin (show FliC Proteins) downregulated the flagellin (show FliC Proteins)-induced and TLR5 (show TLR5 Proteins)-mediated immune responses against flagellin (show FliC Proteins).

  4. TLR5 (show TLR5 Proteins) but not NLRC4 is required for S. pneumoniae FliC (show FliC Proteins)-induced protection.

  5. Data indicate that NLRC4 activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 (show IL18 Proteins) release, and implicate Caspase-8 (show CASP8 Proteins) in NLRC4 inflammasome responses in vivo by generation of doubly deficient in Caspase-1 (show CASP1 Proteins) and Caspase-8 (show CASP8 Proteins).

  6. The tick protein sialostatin L2 binds to annexin A2 (show ANXA2 Proteins) and inhibits NLRC4-mediated inflammasome activation.

  7. LPS (show TLR4 Proteins) activates the MAPK (show MAPK1 Proteins) pathway in macrophages, thus resulting in the upregulation of NLRC4; however, NLRC4 inhibits IL1beta (show IL1B Proteins) and IL18 (show IL18 Proteins) production, contributing to the anti-inflammatory response.

  8. These data reveal mild constitutive activation of the Nlrc4 inflammasome as the results of two SNPs, which leads to the stimulation of hepatocyte proliferation. The increased liver regeneration induces rapid liver mass recovery after hepatectomy and may prevent the development of hepatotoxin-induced liver fibrosis.

  9. While both contributing to pathogen clearance, NLRP3 (show NLRP3 Proteins) more than NLRC4 contributes to deleterious inflammatory responses in cystic fibrosis (show S100A8 Proteins) and correlates with defective NLRC4-dependent IL-1Ra (show IL1RN Proteins) production.

  10. The wheel-like structure of a PrgJ-NAIP2-NLRC4 complex determined by cryogenic electronmicroscopy at 6.6 angstrom reveals that NLRC4 activation involves substantial structural reorganization that creates one oligomerization surface (catalytic surface).

NLRC4 Protein Profile

Protein Summary

In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.

Alternative names and synonyms associated with NLRC4

  • NLR family, CARD domain containing 4 (NLRC4)
  • NLR family, CARD domain containing 4 (Nlrc4)
  • 9530011P19Rik protein
  • Card12 protein
  • CLAN protein
  • CLAN1 protein
  • CLANA protein
  • CLANB protein
  • CLANC protein
  • CLAND protein
  • CLR2.1 protein
  • IPAF protein

Protein level used designations for NLRC4

caspase recruitment domain protein 12 , NLR family CARD domain-containing protein 4 , ice protease-activating factor , ipaf , NLR family, CARD domain containing 4 , CARD, LRR, and NACHT-containing protein , ICE-protease activating factor , NOD-like receptor C4 , caspase recruitment domain family, member 12 , caspase recruitment domain-containing protein 12 , nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4

GENE ID SPECIES
459135 Pan troglodytes
512480 Bos taurus
706378 Macaca mulatta
100070605 Equus caballus
58484 Homo sapiens
268973 Mus musculus
298784 Rattus norvegicus
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