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Pellino 2 plays a critical role for TLR/IL-1R-mediated post-transcriptional control.
Pellino-2 is a tissue-restricted component of a signaling pathway that couples the mouse pelle (show IRAK1 Proteins)-like kinase/IL-1 (show IL1A Proteins) receptor-associated kinase protein to IL-1 (show IL1A Proteins)- or lipopolysaccharide-dependent signaling.
A high-affinity Pellino2 e3 ubiquitin ligase (show MUL1 Proteins) binding domain is specific for phosphothreonine motifs.
interacts with TRAF6 (show TRAF6 Proteins) (tumor necrosis factor (show TNF Proteins) receptor associated factor 6) and TAK1 (transforming growth factor-beta activated kinase 1 (show MAP3K7 Proteins)); can activate the mitogen activated protein kinase (show MAPK1 Proteins) pathway
Pellino2 interacts with kinase-active as well as kinase-inactive IRAK1 (show IRAK1 Proteins) and IRAK4 (show IRAK4 Proteins)
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1. Not required for NF-kappa-B activation (By similarity).
E3 ubiquitin-protein ligase pellino homolog 2
, protein pellino homolog 2
, pellino homolog 2