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ASC CpG methylation may prove to be a primary regulator of the pathogenesis of chronic inflammatory diseases such as heart failure.
besides its role in the inhibition of the NF-kappaB (show NFKB1 ELISA Kits) pathway, NLRC3 (show NLRC3 ELISA Kits) interferes with the assembly and activity of the NALP3 (show NLRP3 ELISA Kits) inflammasome complex by competing with ASC for pro-caspase-1 (show CASP1 ELISA Kits) binding
ASC Induces Apoptosis via Activation of Caspase-9 (show CASP9 ELISA Kits) by Enhancing Gap Junction-Mediated Intercellular Communication.(
These data revealed that cross-linking of ASC(PYD) filaments via ASC(CARD) mediates the assembly of ASC foci.
Down-regulation of mRNA expression was found in cases in which CASP8 (show CASP8 ELISA Kits), TMS1 (show SERINC3 ELISA Kits) and DAPK (show DAPK1 ELISA Kits) were hypermethylated.
loss of ASC driven tumor development is counterbalanced in the identical cell by the inhibition of pro-tumorigenic inflammation in the tumor cell itself
the deubiquitinating enzyme USP50 binds to the ASC protein and subsequently regulates the inflammasome signaling pathway.
ASC self-associates and binds NLRP3 (show NLRP3 ELISA Kits) PYD through equivalent protein regions, with higher binding affinity for the latter. These regions are located at opposite sides of the protein allowing multimeric complex formation previously shown in ASC PYD fibril assemblies.
Our data identify RIPK3 (show RIPK3 ELISA Kits) and the ASC inflammasome as key tumor suppressors in AML (show RUNX1 ELISA Kits).
The role of the danger signals ASC and HMGB1 (show HMGB1 ELISA Kits) in the Fusobacterium nucleatum infection of gingival epithelial cells.
Our cumulative findings indicate that ASC (show STS ELISA Kits) suppresses cancer metastasis and progression via the modulation of cytoskeletal remodeling and the Src (show SRC ELISA Kits)-caspase-8 (show CASP8 ELISA Kits) signaling pathway.
these findings suggest that p205 (show GNB2L1 ELISA Kits) controls expression of Asc (show STS ELISA Kits) mRNA to regulate inflammasome responses. These findings expand on our understanding of immune-regulatory roles for the PYHIN protein family.
this study shows that ASC (show STS ELISA Kits)-dependent Inflammasomes do not shape the commensal gut (show GUSB ELISA Kits) microbiota composition
Our data identify RIPK3 (show RIPK3 ELISA Kits) and the ASC (show STS ELISA Kits) inflammasome as key tumor suppressors in AML (show RUNX1 ELISA Kits).
Data show that T cell-intrinsic PYD and CARD domain containing protein ASC is required for TH17-mediated experimental autoimmune encephalomyelitis (EAE).
Data suggest that interleukin 22 (IL-22 (show IL22 ELISA Kits)) plays a pro-inflammatory/pathogenic role in the onset of antigen-induced arthritis (AIA) through apoptosis-associated speck-like Pycard protein (ASC (show STS ELISA Kits))-dependent stimulation of interleukin-1 beta (IL-1beta (show IL1B ELISA Kits)) production.
report herein that lack of ASC (show STS ELISA Kits) does not confer preferential protection in response to P. aeruginosa acute infection and that ASC (show STS ELISA Kits)(-/-) mice are capable of producing robust amounts of IL-1beta (show IL1B ELISA Kits) comparable with C57BL/6 mice
These data identify a novel non-canonical immunoregulatory function of NLRP3 (show NLRP3 ELISA Kits) and ASC (show STS ELISA Kits) in autoimmunity.
a significant role for NLRP3 (show NLRP3 ELISA Kits) and ASC (show STS ELISA Kits) in prion (show PRNP ELISA Kits) pathogenesis
ASC (show STS ELISA Kits)-driven caspase-1 (show CASP1 ELISA Kits) autoprocessing and speck formation are dispensable for the activation of caspase-1 (show CASP1 ELISA Kits) and the NLRP1b inflammasome.
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm\; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
apoptosis-associated speck-like protein containing a CARD
, caspase recruitment domain-containing protein 5
, target of methylation-induced silencing 1
, PYD and CARD domain-containing protein