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Mouse (Murine) Polyclonal Tlr13 Primary Antibody for ELISA, FACS - ABIN4359925
Schuettpelz, Borgerding, Christopher, Gopalan, Romine, Herman, Woloszynek, Greenbaum, Link: G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling. in Leukemia 2014
S. pyogenes is initially recognized in a phagocytosis-independent manner by TLR2 (show TLR2 Antibodies) and subsequently by TLR13 upon internalization.
TLR13 expressed by immune cells detects bacterial RNA with exquisite sequence specificity.
These data lend support to the conclusion that TLR13 participates in group B streptococcus recognition, although blockade of the function of this receptor can be compensated for by other endosomal toll (show TLR4 Antibodies)-like receptors.
TLR13 activation contributes to the innate response to Gram-positive bacteria, identifying TLR13 as a receptor for bacterial RNA.
these results show that the orphan receptor (show NR1D2 Antibodies) TLR13 in mice recognizes a conserved 23S ribosomal RNA (rRNA) sequence that is the binding site of macrolide, lincosamide, and streptogramin group (MLS) antibiotics (including erythromycin) in bacteria. Notably
the potential role of the novel Toll (show TLR4 Antibodies)-like receptor tlr13 in the recognition of viral infection.
These findings reveal the mechanism of Tlr13 gene regulation, thereby providing insight into the function of Tlr13 in the immune response to pathogen.
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B. activation, cytokine secretion and the inflammatory response (By similarity).
, Toll-like receptor 13