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Human Polyclonal TNIP2 Primary Antibody for EIA, WB - ABIN955282
Handoyo, Stafford, McManus, Baltzis, Peggie, Cohen: IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2. in The Biochemical journal 2009
Show all 5 references for ABIN955282
Human Polyclonal TNIP2 Primary Antibody for ICC, IF - ABIN442650
Banks, Boanca, Lee, Florens, Washburn: Proteins interacting with cloning scars: a source of false positive protein-protein interactions. in Scientific reports 2015
Show all 2 references for ABIN442650
miR (show MLXIP Antibodies)-1180 might act as a tumor promoter by targeting TNIP2 during development of hepatocellular carcinoma.
miR (show MLXIP Antibodies) let-7a-regulated USP35 can inhibit NF-kappaB (show NFKB1 Antibodies) activation by deubiquitination and stabilization of ABIN-2 protein
ABIN-2 acts as a positive regulator of NF-kappaB (show NFKB1 Antibodies)-dependent transcription by activating IKKalpha (show CHUK Antibodies).
A20 (show TNFAIP3 Antibodies), ABIN-1 (show TNIP1 Antibodies)/2, and CARD11 (show CARD11 Antibodies) mutations have prognostic value in gastrointestinal diffuse large B-cell lymphoma
transcription repressed by promyelocytic leukemia protein (show PML Antibodies) expression
FLIP1 has a role in the regulation of NF-kappaB (show NFKB1 Antibodies) activity related to the role of LKB1 (show STK11 Antibodies) in tumor suppression
Endothelial tyrosine kinase Tie2 (show TEK Antibodies) interacts with ABIN-2.
ABIN-2 exerts unexpected function in mediating transcriptional coactivation.
ABIN-2 was found to inhibit endothelial apoptosis and rescue cells from death following growth factor deprivation. Deletion of the carboxy-terminus of ABIN-2 removed its ability to inhibit apoptosis.
optimal TPL-2 stability in vivo requires interaction with ABIN-2 as well as p105
ABIN-2 may function as a negative regulator that downregulates NF-kappaB (show NFKB1 Antibodies) activation during liver regeneration
ABIN-2 acts to positively regulate the Erk (show EPHB2 Antibodies) signaling potential by stabilizing TPL-2 (show MAP3K8 Antibodies).
TNIP2 binds to the C-terminal zinc finger domain of A20 (TNFAIP3\; MIM 191163) and is involved in activation of the ERK (see MAPK3\; MIM 601795) MAP kinase pathway in various cell types (Van Huffel et al., 2001
TNFAIP3-interacting protein 2
, TNFAIP3 interacting protein 2
, A20-binding inhibitor of NF-kappaB activation 2
, A20-binding inhibitor of NF-kappa-B activation 2
, A20-binding inhibitor of NF-kappaB activation-2
, fetal liver LKB1-interacting protein
, A20 binding inhibitor of NF-kappaB activation-2