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RelAp43 interacts with the p105-ABIN2-TPL2 complex and we observe a strong perturbation of this complex in presence of M protein.
Study reports the crystal structure of hABIN2 in complex with linear triubiquitin, which shows the ubiquitins with M1-linkage could form a right-handed helical trimer when bridging two hABIN2 dimers, and thus allow the assembly of a higher-order signaling complex with A20 (show TNFAIP3 Proteins).
Findings suggest an expanded role for the NF-kappaB (show NFKB1 Proteins) network hub protein TNIP2 and reveals an association between TNIP2 and YLPM1, TNIP2 and ESCRT-I (show VPS28 Proteins), together with many RNA processing proteins and a distinct set of mRNAs.
miR (show MLXIP Proteins)-1180 might act as a tumor promoter by targeting TNIP2 during development of hepatocellular carcinoma.
miR (show MLXIP Proteins) let-7a-regulated USP35 can inhibit NF-kappaB (show NFKB1 Proteins) activation by deubiquitination and stabilization of ABIN-2 protein
ABIN-2 acts as a positive regulator of NF-kappaB (show NFKB1 Proteins)-dependent transcription by activating IKKalpha (show CHUK Proteins).
A20 (show TNFAIP3 Proteins), ABIN-1 (show TNIP1 Proteins)/2, and CARD11 (show CARD11 Proteins) mutations have prognostic value in gastrointestinal diffuse large B-cell lymphoma
transcription repressed by promyelocytic leukemia protein (show PML Proteins) expression
FLIP1 has a role in the regulation of NF-kappaB (show NFKB1 Proteins) activity related to the role of LKB1 (show STK11 Proteins) in tumor suppression
Endothelial tyrosine kinase Tie2 (show TEK Proteins) interacts with ABIN-2.
optimal TPL-2 stability in vivo requires interaction with ABIN-2 as well as p105
ABIN-2 may function as a negative regulator that downregulates NF-kappaB (show NFKB1 Proteins) activation during liver regeneration
ABIN-2 acts to positively regulate the Erk (show EPHB2 Proteins) signaling potential by stabilizing TPL-2 (show MAP3K8 Proteins).
TNIP2 binds to the C-terminal zinc finger domain of A20 (TNFAIP3\; MIM 191163) and is involved in activation of the ERK (see MAPK3\; MIM 601795) MAP kinase pathway in various cell types (Van Huffel et al., 2001
TNFAIP3-interacting protein 2
, TNFAIP3 interacting protein 2
, A20-binding inhibitor of NF-kappaB activation 2
, A20-binding inhibitor of NF-kappa-B activation 2
, A20-binding inhibitor of NF-kappaB activation-2
, fetal liver LKB1-interacting protein
, A20 binding inhibitor of NF-kappaB activation-2