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These results point to an important role of the affinity between RNF4 (show RNF4 ELISA Kits) and its cognate RAD6B (show UBE2B ELISA Kits) or UBCH5B in governing the multiplicity of substrate ubiquitination.
Knockdown of UBE2D2 caused an increase in p53 (show TP53 ELISA Kits) protein levels, and knockdown of p53 (show TP53 ELISA Kits) attenuated not only cadmium-induced apoptosis, but also cadmium-induced apoptosis-related gene expression.
mutations having marked effects on function only minimally affect the intermolecular interactions between the AO7 (show RNF25 ELISA Kits) RING and UbcH5B, establishing a high degree of complexity in activation through the RING-E2 interface.
Data show that ubiquitin E2 enzymes UBE2D1 (show UBE2D1 ELISA Kits)/2/3 and E3 ligase RNF138 (show RNF138 ELISA Kits) accumulate at DNA-damage sites and act at early resection stages by promoting CtIP (show RBBP8 ELISA Kits) protein ubiquitylation and accrual.
together with UBE2L3 (show UBE2L3 ELISA Kits) and UBE2N (show UBE2N ELISA Kits), synergistically contribute to Parkin (show PARK2 ELISA Kits)-mediated mitophagy
Presented is the structure of the human dimeric RING domain from BIRC7 (show BIRC7 ELISA Kits) in complex with the E2 UbcH5B covalently linked to Ub.
Whereas UbcH5(A, B and C) is highly efficient in converting IkBa into monoubiquitinated forms, Cdc34 drives ubiquitin (Ub)-Ub conjugation
determined the 2.2 A crystal structure of an intermediate of UbcH5b approximately ubiquitin (Ub) conjugate, which is assembled into an infinite spiral through the backside interaction.
role of WW3 and WW4 domains of Nedd4-2 in dopamine transporter ubiquitination was demonstrated; siRNA analysis demonstrated that this polyubiquitination is mediated by Nedd4-2 cooperation with UBE2D and UBE2L3 E2 ubiquitin-conjugating enzymes
Results describe the crystal structure of a complex between the HECT domain of NEDD4L and the E2 UbcH5B bearing a covalently linked Ub at its active site (UbcH5B approximately Ub).
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
ubiquitin-conjugating enzyme E2D 2
, ubiquitin-conjugating enzyme E2 D2
, p53-regulated ubiquitin-conjugating enzyme 1
, ubiquitin carrier protein D2
, ubiquitin-conjugating enzyme E2-17 kDa 2
, ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5)
, ubiquitin-protein ligase D2
, E2(17)KB 2
, ubc2e ubiquitin conjugating enzyme
, ubiquitin-conjugating enzyme E2(17)KB 2
, ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
, ubiquitin-conjugating enzyme E2 D3
, ubiquitin conjugating enzyme 2e
, ubiquitin carrier protein 4
, ubiquitin conjugating enzyme E2
, ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog)