Apoptosis activator 2

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Purpose An apoptosis activator
Characteristics Apoptosis activator 2 is a cell-permeable apoptosis activator that promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 μM for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC₅₀ > 40 μM).
Purity ≥ 98 % by HPLC
Chemical Name 1-[(3,4-dichlorophenyl)methyl]indole-2,3-dione
Formula C₁₅H₉Cl₂NO₂
Permeability Cell-permeable
Solubility DMSO (~ 30 mg/ml)
Molecular Weight 306.14 g/mol
CAS-No 79183-19-0
Restrictions For Research Use only
Format Solid
Handling Advice Protect from air and light
Storage -20 °C
Expiry Date 36 months