StemRegenin 1

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Functional Studies (Func), Activation (Act), Blocking Reagent (BR), Inhibition Assay (InhA)
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Purpose A promoter of self-renewal of hematopoietic stem cells (HSCs)
Characteristics A cell-permeable purine derivative that acts as an antagonist of aryl hydrocarbon receptor and promotes the self-renewal of hematopoietic stem cells (HSCs). Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. In the absence of cytokines, StemRegenin 1 did not induce proliferation, and at concentrations above 1 µM, it inhibits proliferation.
Purity ≥ 98 % by HPLC
Chemical Name 4-(2-((2-Benzo[b]thiphen-3-yl)-9-isopropyl-9H-purin-6-yl)amino)ethyl)phenol hydrochloride; SR1
Formula C₂₄H₂₃N₅OS.HCl
Permeability Cell-permeable
Solubility DMSO (approx. 10 mM)
Molecular Weight 466 g/mol
CAS-No 1227633-49-9
Restrictions For Research Use only
Format Solid
Handling Advice Protect from light and air
Storage -20 °C
Expiry Date 48 months
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 image for StemRegenin 1 (ABIN809566) StemRegenin 1