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The effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin, leptin (show LEP ELISA Kits), and resistin (show RETN ELISA Kits) in a set of four chair-restraint habituated intact adult male rhesus monkeys.
Adiponectin level partially reflects the severity of liver steatosis, but not the degree of liver inflammation.
High leptin (show LEP ELISA Kits)/adiponectin ratio in pregnancy, particularly in those with gestational diabetes, is associated with an unfavorable CVD risk profile during follow-up.
leptin (show LEP ELISA Kits)-adiponectin imbalance, as reflected by an increase in leptin (show LEP ELISA Kits)/adiponectin ratio, was found to be a better diagnostic biomarker for MS than leptin (show LEP ELISA Kits) or adiponectin alone.
These findings indicate that adiponectin levels are useful markers associated with proteinuria in LN.
Study reports that insulin (show INS ELISA Kits) resistance-related gene polymorphisms effects colorectal cancer (CRC (show CALR ELISA Kits)) risk. The results showed that the gene polymorphism of ADIPOQ rs2241766 was associated with CRC (show CALR ELISA Kits) risk. Furthermore, the interactions of ADIPOQ rs2241766, UCP2 (show UCP2 ELISA Kits) rs659366, FABP2 (show FABP2 ELISA Kits) rs1799883 and red meat consumption may contribute to the risk of CRC (show CALR ELISA Kits).
the high-molecular weight adiponectin/HOMA-IR ratio (HMWA/HOMA-IR ratio) is a minimally invasive biomarker for metabolic syndrome (MetS) that could be clinically useful in prognosing patient outcome.
In patients with acute myocardial infarction but without previously known diabetes, high levels of adiponectin at discharge predicted total mortality.
Association between variation in the ADIPOQ gene and serum adiponectin may arise from effects on mRNA transcription, splicing or stability.
High ADIPOQ levels protects against incident hypertension.
Several single nucleotide polymorphisms in the AdipoQ gene, including the promoter, are associated with increased risk of the development of T2 diabetes and Diabetic kidney disease. [review]
To estimate the frequency of the SNPs (+45T>G and +276G>T) genotypes and investigate the association between the two SNPs and adiponectin concentration, metabolic parameters and risk of T2DM in the Bahraini population. There was no significant difference in allele and genotype frequencies of +276G>T between type T2DM patients and controls. There was no association between both SNPs and metabolic parameters.
Adiponectin (ApN) proves to be a powerful protector of the skeletal muscle capable of reversing the disease progression, thus making it a potential therapeutic agent for Duchenne muscular dystrophy (DMD (show DMD ELISA Kits)).
These results demonstrated that LC along with insulin (show INS ELISA Kits) increases GSH levels thereby improving adiponectin secretion and glucose utilization in adipocytes.
Adiponectin, TNF-alpha (show TNF ELISA Kits), and LOX-1 (show OLR1 ELISA Kits) exert complex regulatory effects on the coronary microvascular endothelial function in atherosclerotic ApoE (show APOE ELISA Kits) knockout mice.
adiponectin inhibited endoplasmic reticulum stress and apoptosis of adipocyte in vivo and in vitro by activating the AMPK (show PRKAA1 ELISA Kits)/PPARalpha (show PPARA ELISA Kits)/ATF2 (show ATF2 ELISA Kits) pathway.
Irisin (show FNDC5 ELISA Kits) improved endothelial function by modulating HO-1 (show HMOX1 ELISA Kits)/ adiponectin axis in perivascular adipose tissue (PVAT) in HFD-induced obese mice. These findings suggest that regulating PVAT function may be a potential mechanism by which irisin (show FNDC5 ELISA Kits) improves endothelial function in obesity.
a unique key feature of the T-cad (show CDH13 ELISA Kits) prodomain is its involvement in binding of the T-cad (show CDH13 ELISA Kits) repeats 1 and 2 to adiponectin; adiponectin positively regulates T-cad (show CDH13 ELISA Kits) abundance
adiponectin maintains intestinal homeostasis and protects against murine colitis through interactions with its receptor AdipoR1 (show ADIPOR1 ELISA Kits) and by modulating adaptive immunity and STAT3 (show STAT3 ELISA Kits) signaling
The KIF5B (show KIF5B ELISA Kits) level was up-regulated during 3T3-L1 adipogenesis. This increase in cytosolic KIF5B (show KIF5B ELISA Kits) was synchronized with the induction of adiponectin. Endogenous KIF5B (show KIF5B ELISA Kits) and adiponectin were partially colocalized at the peri (show POSTN ELISA Kits)-nuclear and cytosolic regions.
The elevation in circulating levels of adiponectin and Fgf15 led to normalized hepatic and serum levels of bile acids, limited hepatic accumulation of toxic bile, attenuated inflammation, and amelioration of liver injury in the ethanol-fed mNT knockout mice.
Female adiponectin null mice displayed impaired fertility, reduced oocytes, disrupted estrous cycle, increased atretic follicles, and impaired late folliculogenesis. There was decrease in serum estradiol and FSH but an increase in LH and testosterone at proestrus. There was reduction of progesterone levels at diestrus, a significant decrease in LH receptor expression as well as in the number of GnRH immunoreactive neurons
Adiponectin affects development of porcine uterine epithelia and reproductive performance through modulation of PI3K/AKT (show AKT1 ELISA Kits) and MAPK (show MAPK1 ELISA Kits) cell signaling pathway.
Results presented in this study indicate the modulatory effect of P4 on adiponectin system in the porcine uterus during early pregnancy, which may suggest the involvement of this adipokine in the early pregnancy establishment.
The fluctuations in adiponectin and orexin concentrations in the plasma and uterine lining fluid (ULF) suggest that the hormones present in ULF are mostly of local origin and that these hormones participate in the processes that accompany early pregnancy.
This study demonstrated the presence of adiponectin and its receptors in the uteri, conceptuses, and trophoblasts of pregnant pigs and that the local adiponectin system is dependent on the stage of pregnancy.
It was concluded that the recombinant ADPN (show PNPLA3 ELISA Kits) could express in eukaryotic expression vector pPICZaA-ADPN (show PNPLA3 ELISA Kits) constructed in this study.
study demonstrated that adiponectin and adiponectin receptors 1 and 2 messenger RNAs and proteins are present in the porcine hypothalamus and that their expression levels are determined by the pig's endocrine status related to the oestrous cycle
This study demonstrated the presence of adiponectin, AdipoR1 (show ADIPOR1 ELISA Kits) and AdipoR2 (show ADIPOR2 ELISA Kits) genes and proteins in the porcine uterus and the effect of the stage of the oestrous cycle on the expression of the adiponectin system.
inhibition of ADIPOQ gene changes the mRNA levels of the adipocyte differentiation transcription factors LPL (show LPL ELISA Kits), PPARgamma (show PPARG ELISA Kits) and AP2 (show TFAP2B ELISA Kits).
Myocardial ADN (show CFD ELISA Kits) was reduced in dilated cardiomyopathy in an AMPK (show PRKAA1 ELISA Kits)-independent manner.
Results indicated that PPARgamma (show PPARG ELISA Kits) is an essential regulatory factor for the transcriptional activity of ERp44 (show ERP44 ELISA Kits), which in turn controls the secretion of adiponectin.
Low level expression of adiponectin mRNA was found in all areas of bovine mammary gland tissues examined. AdipoR1 (show ADIPOR1 ELISA Kits) and AdipoR2 (show ADIPOR2 ELISA Kits) mRNAs were also detected in mammary tissues and their expression was particularly prominent in the parenchyma and cistern.
Data suggest that genetic variation in promoter region of ADIPOQ (SNPs g.81966235C>T, g.81966377T>C, and g.81966364D>I) contribute to adiposity/marbling in skeletal muscle/meat (and thus meat quality) of Hanwoo beef cattle of North Korea.
These data suggest differential contribution of adipose tissue depots to circulating adiponectin.
Association analysis indicated that variable duplication within the ADIPOQ gene is associated with body measurements.
14 polymorphisms of the ADIPOQ gene were observed in Chinese cattle; 2 polymorphisms PR_-135 A>G and PR_-68 G>C were located in the core promoter region of ADIPOQ; 3 haplotypes in the 2 polymorphic sites were detected which produce effects on ADIPOQ transcription and are associated with growth traits
reduced plasma adiponectin belongs to the subset of hormonal adaptations in EL dairy cows facilitating mammary glucose uptake via promotion of insulin (show INS ELISA Kits) resistance
The physiologic status of the ovary has significant effects on the natural expression patterns of adiponectin and its receptors in follicular and luteal cells of bovine ovary.
The disulfide bonds help to maintain the mature octadecameric adiponectin structure and stabilize intermediates during the assembly.
Gobular adiponectin increased NO production in aortic endothlium by increasing NO synthase (show NOS ELISA Kits) activity.
results indicate decreasing adiponectin sensitivity in adipose tissue after calving which might be involved in the reduced insulin (show INS ELISA Kits) sensitivity of adipose tissue during lactation
This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.
adiponectin, C1Q and collagen domain containing
, 30 kDa adipocyte complement-related protein
, adipocyte complement-related 30 kDa protein
, adipose most abundant gene transcript 1 protein
, adipose specific collagen-like factor
, gelatin-binding protein 28
, adipocyte complement related protein
, adipocyte, C1Q and collagen domain containing
, adipocyte, C1q and collagen domain-containing protein
, adipocyte-specific protein AdipoQ
, adipocyte complement related protein of 30 kDa
, adipocyte complement related 30kDa protein