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anti-Human CAB39 Antibodies:
anti-Mouse (Murine) CAB39 Antibodies:
anti-Rat (Rattus) CAB39 Antibodies:
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Cow (Bovine) Polyclonal CAB39 Primary Antibody for WB - ABIN2786954
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
We suggest from those results that Mo25 and Fray operate together or in the same pathway in Drosophila asymmetric processes, and that their function counterbalances Lkb1 (show STK11 Antibodies).
Structural comparison indicates that the overall structures of zebrafish and human MO25 are very similar, suggesting that MO25 has conserved functions in the zebrafish.
plays very important oncogenic roles in hepatocellular carcinoma pathogenesis and progression by activating the ERK (show EPHB2 Antibodies) signaling pathway
miR (show MLXIP Antibodies)-451 directly targets CAB39 and negatively regulates its expression and inhibition of CAB39 contributes to the promoted cell viability and invasion
These data provide molecular understanding of the mechanism by which MO25 isoforms regulates the activity of STE20 (show STK24 Antibodies) family protein kinases.
Authors conclude that miR (show MLXIP Antibodies)-451 represses glioma in vitro and in vivo, likely through targeting CAB39 directly and inhibiting the PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) pathway indirectly.
MO25 is a master regulator of SPAK (show STK39 Antibodies)/OSR1 (show OXSR1 Antibodies) and MST3 (show STK24 Antibodies)/MST4 (show MST4 Antibodies)/YSK1 (show STK25 Antibodies) protein kinases.
study describes structure of the core heterotrimeric LKB1 (show STK11 Antibodies)-STRADalpha-MO25alpha complex, revealing an unusual allosteric mechanism of LKB1 (show STK11 Antibodies) activation; structure also reveals how mutations in Peutz-Jeghers syndrome & sporadic cancers impair LKB1 (show STK11 Antibodies) function
STRADalpha.MO25alpha complexes containing LKB1 (show STK11 Antibodies) variants were equally effective at phosphorylating and activating AMPK (show PRKAA1 Antibodies), BRSK1 (show BRSK1 Antibodies), and BRSK2 (show BRSK2 Antibodies)
These data define a brush border induction pathway downstream of the Lkb1 (show STK11 Antibodies)/Strad (show STRADA Antibodies)/Mo25 polarization complex, yet separate from other polarity events.
ATP and MO25alpha cooperate to maintain STRADalpha in an "active" closed conformation required for LKB1 (show STK11 Antibodies) activation.
Cab39 differentially interacts with WNK4 (show WNK4 Antibodies) and SPAK (show STK39 Antibodies)/OSR1 (show OSR1 Antibodies) to switch the classic two kinase cascade into a signal kinase transduction
Elevated miR (show MLXIP Antibodies)-195 targets the LKB1 (show STK11 Antibodies)/AMPK (show PRKAA1 Antibodies) signaling axis in hypertrophic cardiomyopathy
Quantitative PCR revealed significantly reduced LKB1 (show STK11 Antibodies), MO25alpha, and STRADbeta mRNA in LKB1 (show STK11 Antibodies)(-/-) muscle. These findings demonstrate that the LKB1 (show STK11 Antibodies)-MO25-STRAD (show STRADA Antibodies) complex is the principal AMPKK in skeletal muscle.
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity).
, calcium-binding protein 39
, calcium binding protein 39
, calcium binding protein 39-like
, calcium-binding protein 39-like
, Cab39 protein
, calcium binding protein, 39 kDa