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Site-directed mutagenesis analysis revealed that Leu(358) in CaMKKbeta/Ile(322) in CaMKKalpha confer, at least in part, a distinct recognition of AMPK (show PRKAA1 ELISA Kits) but not of CaMKIalpha (show CAMK1 ELISA Kits).
CaMKK1 does not play a pivotal role in the calcium signaling cascade regulating adrenal aldosterone production.
CAMKK1 might contribute to the risk of lung cancer in Chinese populations.
CaMKIalpha (show CAMK1 ELISA Kits) is a widely expressed protein kinase (show CDK7 ELISA Kits), suggesting that Ca2 (show CA2 ELISA Kits)+ is likely to be functionally important in the control of mitochondrial dynamics through regulation of Drp1 (show CRMP1 ELISA Kits) phosphorylation in neurons and other cell types.[CaMKIalpha (show CAMK1 ELISA Kits)]
Adiponectin activates AMP-activated protein kinase (show PRKAA2 ELISA Kits) in muscle cells via APPL1 (show APPL1 ELISA Kits)/LKB1 (show STK11 ELISA Kits)-dependent and phospholipase C (show PLC ELISA Kits)/Ca2+/Ca2 (show CA2 ELISA Kits)+/calmodulin-dependent protein kinase (show CDK7 ELISA Kits) kinase-dependent pathways
the CaMKK (show CAMKK2 ELISA Kits)-CaMKIalpha (show CAMK1 ELISA Kits) cascade is required for the axonal growth effect of Wnt5a (show WNT5A ELISA Kits) during neuronal polarization.
Data (including data from knockout mice) suggest that up-regulation of Camkk1 and calcium signaling stimulates muscle growth via up-regulation of mTORC1 (mammalian target of rapamycin (show FRAP1 ELISA Kits) complex 1) signaling and muscle protein biosynthesis.
caCaMKKalpha stimulates glucose uptake additively with insulin, and in insulin-resistant muscle, and alters the phosphorylation of TBC1D1/TBC1D4.
ERK (show EPHB2 ELISA Kits) activation and neurite outgrowth in response to depolarization are mediated by CaMKK (show CAMKK2 ELISA Kits) activation of CaMKI (show CAMK1 ELISA Kits)
In muscles from wild-type mice CaMKKalpha increased in vivo deoxyglucose uptake and AMPKalpha1 (show PRKAA1 ELISA Kits) and -alpha2 activities 2.5-fold.
Data show that CaMKK (show CAMKK2 ELISA Kits) is the kinase responsible for alpha-lipoic acid induced AMP-activated protein kinase (show PRKAA2 ELISA Kits) activation in C2C12 myotubes.
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene.
, camkk 1
, calcium/calmodulin-dependent protein kinase kinase 1
, calcium/calmodulin-dependent protein kinase kinase 1, alpha
, calcium/calmodulin-dependent protein kinase 1 alpha-like
, calcium/calmodulin-dependent protein kinase kinase 1-like
, CAMKK alpha protein
, caM-KK 1
, caM-KK alpha
, caM-kinase IV kinase
, caM-kinase kinase 1
, caM-kinase kinase alpha
, caMKK 1
, calcium/calmodulin-dependent protein kinase kinase alpha
, caMKK alpha
, calcium calmodulin dependent protein kinase kinase alpha
, alpha CaMKK