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CRTC2 strongly enhances GR-induced transcriptional activity of glucocorticoid-responsive genes.
Our results establish a role for CRTC2 as a lymphoma tumor suppressor gene
the high expression of CRTC2 and PROM1 may play an important role in the occurrence and hereditary, and also advance the potential pathways that integrate genetic variants in the development of NSCLC.
The data from the current study demonstrated novel PROM1 and CRTC2 mutations, which could promote lung cancer development.
These results clearly indicate that non-phosphorylated CRTC2 strongly enhances hepatitis b virus biosynthesis through inducing PGC1alpha expression.
Phosphorylation of CRTC2 at its AMPK (show PRKAA1 ELISA Kits) target site, Ser (show SIGLEC1 ELISA Kits) 171, dictated its subcellular localization, and the activation of aromatase (show CYP19A1 ELISA Kits) PII in preadipocytes.
CRTC2 enhances CREB (show CREB1 ELISA Kits) phosphorylation through an association with the protein arginine methyltransferase 5 (PRMT5 (show PRMT5 ELISA Kits)).
Mechanism of CREB (show CREB1 ELISA Kits) recognition and coactivation by the CREB (show CREB1 ELISA Kits)-regulated transcriptional coactivator CRTC2
The lipogenic effects of GIP (show GIP ELISA Kits) in the presence of insulin (show INS ELISA Kits) are therefore at least partially mediated by upregulation of adipocyte LPL (show LCP1 ELISA Kits) gene transcription through a pathway involving PI3-K (show PIK3CA ELISA Kits)/PKB (show AKT1 ELISA Kits)/AMPK (show PRKAA1 ELISA Kits)-dependent CREB (show CREB1 ELISA Kits)/TORC2 activation.
the association of Pin1 (show PIN1 ELISA Kits) with CRTC2 to decrease the nuclear CBP.CRTC.CREB complex.
the protein expression of adipose tissue CRTC 2 was reduced in mice with a combined application of change to general diet and exercise. In addition, while the protein expressions of lipase (show LIPG ELISA Kits) ATGL (show PNPLA2 ELISA Kits) and HSL (show LIPE ELISA Kits) were reduced in the mice fed with the high fat diet continually after obesity was induced
CRTC2 promotes Th17 cell differentiation via stimulation of IL-17A (show IL17A ELISA Kits) and IL-17F (show IL17F ELISA Kits) expression by binding to CREB (show CREB1 ELISA Kits) over both promoters. CRTC2-mutant mice have decreased Th17 cells, and they are protected from experimental autoimmune encephalitis.
chronic increases in CRTC2 activity in the liver are indeed sufficient to promote hepatic insulin (show INS ELISA Kits) resistance and to disrupt glucose homeostasis
cAMP, SIK (show SIK1 ELISA Kits) and CRTC mediate StAR expression through activation of individual StAR gene loci.
RICTOR (show RICTOR ELISA Kits)/mTORC2 is important for interactions between vasculature, adipocytes, and brain to tune physiological outcomes, such as blood pressure and locomotor activity.
CREB regulated transcription coactivator 2 (CRTC2) functions as a mediator of mTOR (show FRAP1 ELISA Kits) signalling to modulate COPII-dependent SREBP1 (show SREBF1 ELISA Kits) processing
Translational activation of CREB (show CREB1 ELISA Kits) is caused by elevated phospho-elF2alpha (show EIF2S1 ELISA Kits).
CRTC2 mRNA levels down-regulation improves glucose control and other markers of metabolic function in experimental type 2 diabetes mellitus.
PRMT6 (show PRMT6 ELISA Kits) is involved in the regulation of hepatic glucose metabolism in a CRTC2-dependent manner.
Crtc2-overexpressing mice have increased myofiber cross-sectional area, greater intramuscular triglycerides and glycogen (show GYS1 ELISA Kits) content.
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.
CREB regulated transcription coactivator 2
, CREB-regulated transcription coactivator 2
, CREB-regulated transcription coactivator 2-like
, transducer of regulated cAMP response element-binding protein (CREB) 2
, transducer of CREB protein 2
, transducer of regulated cAMP response element-binding protein 2