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CRTC2 strongly enhances GR-induced transcriptional activity of glucocorticoid-responsive genes.
critical pathophysiologic event in the evolution of HER2 (show ERBB2 ELISA Kits)-amplified cancers is the loss of the input signals that normally drive TORC2 signaling, repositioning it under Akt (show AKT1 ELISA Kits) dependency, and fundamentally altering the role of HER3 (show ERBB3 ELISA Kits)
Our results establish a role for CRTC2 as a lymphoma tumor suppressor gene
In neuroblastoma (show ARHGEF16 ELISA Kits), transcription of HIF2A (show EPAS1 ELISA Kits) is strongly dependent on mTORC2.
the high expression of CRTC2 and PROM1 may play an important role in the occurrence and hereditary, and also advance the potential pathways that integrate genetic variants in the development of NSCLC.
The data from the current study demonstrated novel PROM1 and CRTC2 mutations, which could promote lung cancer development.
These results clearly indicate that non-phosphorylated CRTC2 strongly enhances hepatitis b virus biosynthesis through inducing PGC1alpha expression.
Phosphorylation of CRTC2 at its AMPK (show PRKAA1 ELISA Kits) target site, Ser (show SIGLEC1 ELISA Kits) 171, dictated its subcellular localization, and the activation of aromatase (show CYP19A1 ELISA Kits) PII in preadipocytes.
CRTC2 enhances CREB (show CREB1 ELISA Kits) phosphorylation through an association with the protein arginine methyltransferase 5 (PRMT5 (show PRMT5 ELISA Kits)).
we found that overexpressed RIOK2 formed a complex with RIOK1 (show RIOK1 ELISA Kits), mTor (show FRAP1 ELISA Kits), and mTor (show FRAP1 ELISA Kits)-complex-2(TORC2) components, and that overexpressed RIOK2 upregulated Akt (show AKT1 ELISA Kits) signaling and promoted tumorigenesis
demonstrates that mTORC2 is implicated in maintaining contractile function of the pressure-overloaded male mouse heart
we found that pharmacologically boosting either mTORC2 or actin polymerization enhances long-term memory
mTORC2 has a central role in IFNgamma signaling and type II IFN responses
CRTC2 promotes Th17 cell differentiation via stimulation of IL-17A (show IL17A ELISA Kits) and IL-17F (show IL17F ELISA Kits) expression by binding to CREB (show CREB1 ELISA Kits) over both promoters. CRTC2-mutant mice have decreased Th17 cells, and they are protected from experimental autoimmune encephalitis.
chronic increases in CRTC2 activity in the liver are indeed sufficient to promote hepatic insulin (show INS ELISA Kits) resistance and to disrupt glucose homeostasis
cAMP, SIK (show SIK1 ELISA Kits) and CRTC mediate StAR expression through activation of individual StAR gene loci.
our study demonstrates the existence of a direct crosstalk between mTORC2 and MST1 (show MST1 ELISA Kits) that is critical for cardiac cell survival and growth.
RICTOR (show RICTOR ELISA Kits)/mTORC2 is important for interactions between vasculature, adipocytes, and brain to tune physiological outcomes, such as blood pressure and locomotor activity.
CREB regulated transcription coactivator 2 (CRTC2) functions as a mediator of mTOR (show FRAP1 ELISA Kits) signalling to modulate COPII-dependent SREBP1 (show SREBF1 ELISA Kits) processing
Our findings provide new insight into the role of mTORC2 in regulating dendritic cell function
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5.
CREB regulated transcription coactivator 2
, CREB-regulated transcription coactivator 2
, CREB-regulated transcription coactivator 2-like
, transducer of regulated cAMP response element-binding protein (CREB) 2
, transducer of CREB protein 2
, transducer of regulated cAMP response element-binding protein 2