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Browse our anti-EEF2K (EEF2K) Antibodies

Full name:
anti-Eukaryotic Elongation Factor-2 Kinase Antibodies (EEF2K)
On www.antibodies-online.com are 100 Eukaryotic Elongation Factor-2 Kinase (EEF2K) Antibodies from 17 different suppliers available. Additionally we are shipping EEF2K Kits (11) and EEF2K Proteins (9) and many more products for this protein. A total of 127 EEF2K products are currently listed.
Synonyms:
C86191, eEF-2K, HSU93850, SMEF2K
list all antibodies Gene Name GeneID UniProt
EEF2K 29904 O00418
EEF2K 13631 O08796
EEF2K 25435 P70531

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anti-Human EEF2K Antibodies:

anti-Mouse (Murine) EEF2K Antibodies:

anti-Rat (Rattus) EEF2K Antibodies:

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Top referenced anti-EEF2K Antibodies

  1. Rat (Rattus) Polyclonal EEF2K Primary Antibody for IHC, ELISA - ABIN1531227 : Usui, Nijima, Sakatsume, Otani, Kameshima, Okada, Yamawaki: Eukaryotic elongation factor2 kinase controls proliferation and migration of vascular smooth muscle cells. in Acta physiologica (Oxford, England) 2014 (PubMed)

  2. Human Polyclonal EEF2K Primary Antibody for IHC (p), IHC - ABIN407656 : Liu, Zhang, Wu, Zhou, Ren, Yang, Ming, Chen, Wang, Zhang, Yang: Inhibition of elongation factor-2 kinase augments the antitumor activity of Temozolomide against glioma. in PLoS ONE 2013 (PubMed)

  3. Human Polyclonal EEF2K Primary Antibody for IHC, ELISA - ABIN1450482 : Martin, Han, Gordon, Terry, Prabhakar, She, Xie, Hellsten, Chan, Altherr, Couronne, Aerts, Bajorek, Black, Blumer, Branscomb, Brown, Bruno, Buckingham, Callen, Campbell, Campbell, Campbell, Caoile et al.: The sequence and analysis of duplication-rich human chromosome 16. ... in Nature 2004 (PubMed)

  4. Human Polyclonal EEF2K Primary Antibody for ELISA, WB - ABIN1533169 : Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006 (PubMed)

More Antibodies against EEF2K Interaction Partners

Human Eukaryotic Elongation Factor-2 Kinase (EEF2K) interaction partners

  1. This study reports how phosphorylation of a regulatory site (Ser-500) integrates with Ca(2+) and CaM to influence eEF-2K activity.

  2. Article reviews recent evidence concerning the role of eEF2K in human diseases; growing evidence links eEF2K to a range of human diseases, including cardiovascular conditions (atherosclerosis, via macrophage survival) and pulmonary arterial hypertension, as well as solid tumors, where eEF2K appears to play contrasting roles depending on tumor type and stage. eEF2K is also involved in neurological disorders. [Review]

  3. Recent evidence shows that eEF2K plays an important role in learning and memory, processes that require the synthesis of new proteins and involve Ca-mediated signalling. eEF2K is activated under conditions of nutrient and energy depletion

  4. Results show that eEF2K is rapidly activated in response to acidosis in cells, an effect that is followed by its downregulation.

  5. silencing of EEF2K promotes autophagic survival via activation of the AMPK (show PRKAA1 Antibodies)-ULK1 (show ULK1 Antibodies) pathway in colon cancer cells

  6. Deletion of Pten (show PTEN Antibodies) and p53 (show TP53 Antibodies) in mammary epithelium accelerates triple-negative breast cancer with dependency on eEF2K activity.

  7. Data show that eEF2K is activated during hypoxia or upon inhibition of prolyl hydroxylases and inhibited by its hydroxylation on a highly conserved proline residue, restricting its activity during normoxia.

  8. our results show, for the first time, that eEF-2K is involved in regulation of the invasive phenotype of PaCa cells through promoting a new signalling pathway, which is mediated by TG2 (show TGM2 Antibodies)/b1 integrin/Src (show SRC Antibodies)/uPAR (show PLAUR Antibodies)/MMP-2 (show MMP2 Antibodies)

  9. data suggest that achieving an active conformation, rather than eEF2K activity per se, is required for its susceptibility to degradation.

  10. data show that the major trigger for activation of eEF2K upon mild cooling is the release of Ca2 (show CA2 Antibodies)+ ions from the endoplasmic reticulum (ER)

Mouse (Murine) Eukaryotic Elongation Factor-2 Kinase (EEF2K) interaction partners

  1. results suggest that protective versus pro-apoptotic roles of eEF2K depend on the type of cells: eEF2K is protective in highly proliferative cells, such as small intestinal stem cells and cancer cells, which are more susceptible to mitotic catastrophe.

  2. Using an eEF2K gain-of-function design in vitro as well as eEF2K-KO mice, we show that eEF2K activity regulates the excitation/inhibition balance by downregulating vesicle release at inhibitory synapses and tonic inhibition. This translates into a reduced susceptibility of eEF2K-KO mice for seizures without major behavioral alterations with the exception of impaired contextual and trace fear memory

  3. hese data suggest that mmu-miR (show MLXIP Antibodies)-125b decreases NO production in activated macrophages at least partially by suppressing eEF2K and CCNA2 (show CCNA2 Antibodies) expression.

  4. eEF2K protects cancer cells against nutrient starvation by inhibiting protein synthesis rather than by activating autophagy.

  5. The findings of this study suggested that eEF2K likely contributes to neuronal function by regulating the synthesis of microtubule-related proteins.

  6. eEF2K mediates PDGF (show PDGFA Antibodies)-BB-induced SMCs proliferation and migration through activating ERK (show EPHB2 Antibodies), Akt (show AKT1 Antibodies), p38 (show CRK Antibodies) and HSP27 (show HSPB1 Antibodies) signals in a calmodulin (show Calm2 Antibodies)-dependent manner

  7. Results show that eEF2K is rapidly activated in response to acidosis in cells, an effect that is followed by its downregulation.

  8. Data show that eEF2K is activated during hypoxia or upon inhibition of prolyl hydroxylases and inhibited by its hydroxylation on a highly conserved proline residue, restricting its activity during normoxia.

  9. data suggest that achieving an active conformation, rather than eEF2K activity per se, is required for its susceptibility to degradation.

  10. Because eEF2K activity in cells of the hematopoietic compartment contributes to atherosclerosis development, drugs inhibiting eEF2K might have a beneficial effect in treatment of atherosclerosis.

EEF2K Antigen Profile

Antigen Summary

This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment.

Alternative names and synonyms associated with EEF2K

  • eukaryotic elongation factor-2 kinase (EEF2K) antibody
  • eukaryotic elongation factor-2 kinase (eef2k) antibody
  • eukaryotic elongation factor-2 kinase (Eef2k) antibody
  • C86191 antibody
  • eEF-2K antibody
  • HSU93850 antibody
  • SMEF2K antibody

Protein level used designations for EEF2K

eukaryotic elongation factor-2 kinase , eukaroytic elongation factor 2 kinase-like , calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase , calcium/calmodulin-dependent eukaryotic elongation factor-2 kinase , calmodulin-dependent protein kinase III , eEF-2 kinase , elongation factor-2 kinase , eukaroytic elongation factor 2 kinase , eukaryotic elongation factor 2 kinase , eEF-2K , elongation factor 2 kinase

GENE ID SPECIES
100058387 Equus caballus
100145184 Xenopus (Silurana) tropicalis
100390187 Callithrix jacchus
100457763 Pongo abelii
100482707 Ailuropoda melanoleuca
100547079 Meleagris gallopavo
100568209 Anolis carolinensis
100591954 Nomascus leucogenys
29904 Homo sapiens
13631 Mus musculus
25435 Rattus norvegicus
479812 Canis lupus familiaris
100523723 Sus scrofa
521730 Bos taurus
416619 Gallus gallus
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