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Study showed that endothelial cells (ECs)relied on glycolysis rather than on oxidative phosphorylation for ATP production and that loss of the glycolytic activator PFKFB3 in ECs impaired vessel formation.
Study provides evidence that PFKFB3 overexpression occupied a dominant position in sorafenib resistance of hepatocellular carcinoma cells.
This work has uncovered a novel function of the enzymes PFKFB3 and PFKFB4 (show PFKFB4 ELISA Kits) in ovarian cancer cells during mitotic arrest
PFK-2 seems to be a strategic element that links NADPH oxidase (show NOX1 ELISA Kits) activation and glycolysis modulation, and, as such, is proposed as a potential therapeutic target in inflammatory diseases.
Data suggest that hepatic glucokinase (show GCK ELISA Kits) activity is regulated by reversible binding to specific inhibitor protein glucokinase regulatory protein (GKRP (show GCKR ELISA Kits)) and by binding to activator proteins such as 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase (PFK2/FBP2 (show KHSRP ELISA Kits)); changes in glucokinase (show GCK ELISA Kits) expression and activity are associated with poorly controlled type 2 diabetes and nonalcoholic fatty liver disease. [REVIEW]
PFKFB3 was a novel downstream substrate of mTOR (show FRAP1 ELISA Kits) signaling pathway as PFKFB3 level was augmented after knocking down TSC2 (show TSC2 ELISA Kits) in THP1 (show GLI2 ELISA Kits) and OCI-AML3 (show RUNX2 ELISA Kits) acute myeloid leukemia (show BCL11A ELISA Kits) cells.
Taken together, our study identifies PFKFB3 as a key TGFbeta1 (show TGFB1 ELISA Kits) effector protein that mediates TGFbeta1 (show TGFB1 ELISA Kits)'s effect on Snail (show SNAI1 ELISA Kits) expression, invasion, and glycolysis.
we investigate the crosstalk between PFKFB3 and TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator (show C12orf5 ELISA Kits)), a protein known to protect cells from oxidative stress. Our results show consistent TIGAR (show C12orf5 ELISA Kits) induction in HeLa cells in response to PFKFB3 knockdown
Knockdown of PFKFB3 by siRNAs significantly inhibited the proliferation and migration abilities of gastric cancer cells. Our data suggest that PFKFB3 might be a potential biomarker for gastric cancer and anti-neoplastic targeting gene.
The targeting of MCT1 (show CMA1 ELISA Kits) and PFKFB3 regulated cell proliferation.
the novel role of PFKFB3 in induction of paclitaxel resistance by raising lactate production and activating TLR4 (show TLR4 ELISA Kits) signaling, was characterized.
The PFKFB3-driven glycolysis selectively promotes the extrinsic antiviral capacity of macrophages, via metabolically supporting the engulfment and removal of virus-infected cells.
Blockage of glycolysis by targeting PFKFB3 alleviates sepsis-related acute lung injury via suppressing inflammation and apoptosis of alveolar epithelial cells.
overexpression of PFKFB3 in HEK293 cells potentiated insulin (show INS ELISA Kits)-dependent phosphorylation of Akt (show AKT1 ELISA Kits) and Akt (show AKT1 ELISA Kits) substrates
Data show that inhibition of AMP (show TMPRSS5 ELISA Kits)-Activated kinase (AMPK (show PRKAA1 ELISA Kits)) or 6-phosphofructo-2-kinase-fructose-2,6-biphosphatase 3 (PFKFB3) results in enhanced cell death in mitosis.
Shear stress-mediated repression of endothelial cell metabolism via KLF2 (show KLF2 ELISA Kits) and PFKFB3 controls endothelial cell phenotype.
PFKFB3 is a promising target for the reduction of endothelial glycolysis and its related pathological angiogenesis
PFKFB3/iPFK2 responds to re-feeding, which in turn stimulates hypothalamic glycolysis and decreases hypothalamic AMPK (show PRKAA1 ELISA Kits) phosphorylation and alters neuropeptide expression in a pattern that is associated with suppression of food intake.
High-fat diet feeding stimulates intestine 6-phosphofructo-2-kinase expression and induces intestine inflammatory response.
a unique role for PFKFB3/iPFK2 in adipocytes with regard to diet-induced inflammatory responses in both adipose and liver tissues.
Synthesis and degradation of fructose 2,6-bisphosphate (By similarity).
, fructose-2,6-biphosphatase 3
, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
, 6PF-2-K/Fru-2,6-P2ASE brain/placenta-type isozyme
, 6PF-2-K/Fru-2,6-P2ase 3
, PFK/FBPase 3
, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3-like
, 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase
, 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase
, 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme
, fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase
, inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
, renal carcinoma antigen NY-REN-56
, inducible 6-phosphofructo-2-kinase
, 6PF-2-K/Fru-2,6-P2ASE brain-type isozyme
, 6-P2ase liver isozyme
, 6PF-2-K/Fru-2,6-P2ase liver isozyme