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Browse our PIK3C3 Proteins (PIK3C3)

Full name:
Phosphoinositide-3-Kinase, Class 3 Proteins (PIK3C3)
On www.antibodies-online.com are 5 Phosphoinositide-3-Kinase, Class 3 (PIK3C3) Proteins from 4 different suppliers available. Additionally we are shipping PIK3C3 Antibodies (171) and PIK3C3 Kits (3) and many more products for this protein. A total of 183 PIK3C3 products are currently listed.
Synonyms:
5330434F23Rik, hVps34, im:7147158, Vps34, wu:fc13g06, wu:fz51e12, zgc:112016, zgc:113009
list all proteins Gene Name GeneID UniProt
PIK3C3 5289 Q8NEB9
Rat PIK3C3 PIK3C3 65052 O88763
PIK3C3 225326 Q6PF93

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PIK3C3 Proteins (PIK3C3) by Origin

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More Proteins for PIK3C3 Interaction Partners

Human Phosphoinositide-3-Kinase, Class 3 (PIK3C3) interaction partners

  1. Study identifies a key role of Cul3 (show CUL3 Proteins)-KLHL20 (show KLHL20 Proteins) in autophagy termination by controlling autophagy-dependent turnover of ULK1 (show ULK1 Proteins) and VPS34 complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism.

  2. cis (show CISH Proteins)-unsaturated fatty acids require neither BECN1 (show BECN1 Proteins) nor PIK3C3 to stimulate the autophagic flux

  3. tubulation requires mTOR (show FRAP1 Proteins) activity, and we identified two direct mTOR (show FRAP1 Proteins) phosphorylation sites on UVRAG (show UVRAG Proteins) (S550 and S571) that activate VPS34.

  4. High expression of PI3K (show PIK3CA Proteins) core complex genes is associated with poor prognosis in chronic lymphocytic leukemia.

  5. reveal a novel function of GABP in the regulation of autophagy via transcriptional activation of the BECN1 (show BECN1 Proteins)-PIK3C3 complex

  6. Data indicte that Compound 31 constitutes an optimized class III phosphoinositide 3-kinase Vps34 inhibitor that could be used to investigate cancer biology.

  7. VPS34-IN1 will provide a useful tool to decipher the kinase-dependent functions of Vps34, with acute changes in SGK3 (show SGK3 Proteins) phosphorylation and subcellular localization being new biomarkers of Vps34 activity.

  8. DNA damage regulates Vps34 complexes and its downstream mechanisms, including autophagy and receptor endocytosis, through SCF (show KITLG Proteins) (Skp1 (show SKP1 Proteins)-Cul1 (show CUL1 Proteins)-F-box)-mediated ubiquitination and degradation

  9. Insulin (show INS Proteins) can spatially regulate VPS34 activity through Src (show SRC Proteins)-mediated tyrosine phosphorylation.

  10. Ric-8A (show RIC8A Proteins) co-localized with Vps34 at the midbody.

Pig (Porcine) Phosphoinositide-3-Kinase, Class 3 (PIK3C3) interaction partners

  1. These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.

  2. confirmed that the polymorphism in PIK3C3 (C2604T) has the potential to be a genetic marker for production traits in Duroc pigs

Mouse (Murine) Phosphoinositide-3-Kinase, Class 3 (PIK3C3) interaction partners

  1. PAQR3 (show PAQR3 Proteins) controls autophagy by integrating AMPK (show PRKAA1 Proteins) signaling to enhance ATG14L-associated PI3K activity

  2. Depletion of hepatic Vps15, the regulatory subunit of class III PI3K, increases insulin (show INS Proteins) sensitivity and Akt (show AKT1 Proteins) signaling.

  3. Study identifies a key role of Cul3 (show CUL3 Proteins)-KLHL20 (show KLHL20 Proteins) in autophagy termination by controlling autophagy-dependent turnover of ULK1 (show ULK1 Proteins) and VPS34 complex subunits and reveals the pathophysiological functions of this autophagy termination mechanism.

  4. Beclin 1 (show BECN1 Proteins) regulates endosome pathways via the UVRAG (show UVRAG Proteins)-VPS34 complex.

  5. Class III PI3K plays a central role in the transition of cardiac hypertrophy to heart failure via a prolonged activation of autophagy.

  6. tubulation requires mTOR (show FRAP1 Proteins) activity, and we identified two direct mTOR (show FRAP1 Proteins) phosphorylation sites on UVRAG (show UVRAG Proteins) (S550 and S571) that activate VPS34.

  7. These data reveal a key role for NRBF2 in the assembly of the specific Atg14L-Beclin 1-Vps34-Vps15 complex for autophagy induction.

  8. Vps34 is a main phosphatidylinositol 3-phosphate source for constitutive PIKfyve (show PIKFYVE Proteins) functionality.

  9. Functional relationships between PIK3C3, dynactin (show DCTN1 Proteins), and AnkB (show ANKH Proteins) promote axonal transport of organelles and are required for normal axon length.

  10. a novel association between deletion of Pik3c3 and muscular dystrophy.

PIK3C3 Protein Profile

Protein Summary

Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis (By similarity).

Alternative names and synonyms associated with PIK3C3

  • phosphatidylinositol 3-kinase, catalytic subunit type 3 (PIK3C3)
  • phosphoinositide-3-kinase, class 3 (pik3c3)
  • phosphatidylinositol 3-kinase, catalytic subunit type 3 (Pik3c3)
  • phosphoinositide-3-kinase, class 3 (Pik3c3)
  • phosphoinositide-3-kinase, class 3 (PIK3C3)
  • 5330434F23Rik protein
  • hVps34 protein
  • im:7147158 protein
  • Vps34 protein
  • wu:fc13g06 protein
  • wu:fz51e12 protein
  • zgc:112016 protein
  • zgc:113009 protein

Protein level used designations for PIK3C3

phosphoinositide-3-kinase, class 3 , phosphatidylinositol 3-kinase catalytic subunit type 3 , PI3K type 3 , PI3-kinase type 3 , ptdIns-3-kinase type 3 , phosphoinositide-3-kinase class 3 , catalytic phosphatidylinositol 3-kinase 3 , PtdIns-3-kinase type 3 , phosphatidylinositol 3-kinase p100 subunit , class 3 phosphoinositide-3-kinase , PI-3K Vps34p

GENE ID SPECIES
100053039 Equus caballus
446671 Xenopus laevis
455385 Pan troglodytes
548346 Danio rerio
5289 Homo sapiens
503700 Sus scrofa
65052 Rattus norvegicus
490477 Canis lupus familiaris
534815 Bos taurus
225326 Mus musculus
100857877 Gallus gallus
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