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Browse our PRKAG3 Proteins (PRKAG3)

Full name:
Protein Kinase, AMP-Activated, gamma 3 Non-Catalytic Subunit Proteins (PRKAG3)
On www.antibodies-online.com are 5 Protein Kinase, AMP-Activated, gamma 3 Non-Catalytic Subunit (PRKAG3) Proteins from 4 different suppliers available. Additionally we are shipping PRKAG3 Antibodies (64) and many more products for this protein. A total of 74 PRKAG3 products are currently listed.
Synonyms:
Amkg3, AMPKG3, AMPKg3L, AMPKg3S, PRKAG3, prkag3-a
list all proteins Gene Name GeneID UniProt
Rat PRKAG3 PRKAG3 301518  
PRKAG3 53632 Q9UGI9
PRKAG3 241113 Q8BGM7

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PRKAG3 Proteins (PRKAG3) by Origin

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Horse (Equine) Protein Kinase, AMP-Activated, gamma 3 Non-Catalytic Subunit (PRKAG3) interaction partners

  1. Alleles of 2 equine AMPK (show PRKAA1 Proteins) gamma subunit genes had no causative role in polysaccharide storage myopathy in horses

Human Protein Kinase, AMP-Activated, gamma 3 Non-Catalytic Subunit (PRKAG3) interaction partners

  1. Low PRKAA2 (show PRKAA2 Proteins) expression is associated with follicular lymphoma.

  2. Through the enhancement of skeletal muscle glucose uptake and increased mitochondrial content, the R225W mutation of the gene encoding AMP-activated protein kinase (AMPK (show PRKAA2 Proteins))gamma(3)may significantly enhance exercise performance.

  3. Purification and characterization of truncated human AMPK alpha 2 (show PRKAA2 Proteins) beta 2 gamma 3 heterotrimer from baculovirus-infected insect cells

  4. identified for the first time a mutation in the skeletal muscle-specific (show EIF3K Proteins) regulatory gamma(3) subunit of AMPK (show PRKAA1 Proteins) in humans

  5. data show that different mutations in gamma3 exert different effects on allosteric regulation of alpha2beta2gamma3 complex by AMP (show APRT Proteins), whereas we find no evidence for their role in regulating the level of phosphorylation of alpha2 by upstream kinases.

  6. Genetic variability in PRKAG3 does not seem to have a major effect on glucose metabolism, but play a role in lipoprotein metabolism in humans.

  7. Variants in genes for AMPKalpha2 (show PRKAA2 Proteins) and AMPKgamma3 were not associated with PCOS or its component traits.

Cow (Bovine) Protein Kinase, AMP-Activated, gamma 3 Non-Catalytic Subunit (PRKAG3) interaction partners

  1. Association between polymorphism in bovine PRKAG3 gene and milk production traits.

Pig (Porcine) Protein Kinase, AMP-Activated, gamma 3 Non-Catalytic Subunit (PRKAG3) interaction partners

  1. Activity of glycogen synthase without the allosteric activator glucose 6-phosphate was decreased in gain of function AMPKgamma3(R200Q) relative to all other genotypes

  2. allelic frequencies of PRKAG3 in several pig breeds

  3. The variation in the promoter region of the porcine PRKAG3 gene has associations with meat quality phenotypes, including traits which are influenced by glycolytic potential and muscle metabolism in a breed-dependent manner.

  4. PRKAG3 mutation influences muscle characteristics and promotes an oxidative phenotype to a varying degree among muscles with different functions

  5. increased rate of glycogen (show GYS1 Proteins) synthesis following exercise in pigs carrying the PRKAG3 mutation correlates with an increased signalling response of Akt (show AKT1 Proteins) and its substrate, AS160 (show TBC1D4 Proteins).

  6. Genetic variation of PRKAG3 was studied in indigenous breeds of China.

  7. the R225Q mutation of PRKAG3 is associated with higher basal AMPK (show PRKAA1 Proteins) activity and diminished AMP (show TMPRSS5 Proteins) dependence

  8. findings suggest that the R200Q mutation results in a constitutively active enzyme, leading to hyperaccumulation of glycogen (show GYS1 Proteins) due to the increased influx of glucose

Mouse (Murine) Protein Kinase, AMP-Activated, gamma 3 Non-Catalytic Subunit (PRKAG3) interaction partners

  1. gamma3-AMPK (show PRKAA1 Proteins) down-regulation is a rapid physiological muscle response observed in mouse after running exercise or fasting, two situations leading to PPARbeta (show PPARD Proteins) activation.

  2. AMPK (show PRKAA1 Proteins) acts as the primordial trigger for fasting- and exercise-induced adaptations in skeletal muscle and that activation of SIRT1 (show SIRT1 Proteins) and its downstream signaling pathways are improperly triggered in AMPK (show PRKAA1 Proteins)-deficient states.

  3. Gamma3 subunit of AMPK (show PRKAA1 Proteins) is highly expressed in fast-twitch glycolytic skeletal muscle, and wild-type gamma3 functions in the regulation of alpha1 catalytic activity, but it is not associated with changes in muscle glycogen (show GYS1 Proteins) concentrations

  4. functional studies of the protein kinase (show CDK7 Proteins), AMP (show TMPRSS5 Proteins)-activated, gamma 3 (AMPK3) isoform further support the close connection between glycogen (show GYS1 Proteins) content and exercise performance in skeletal muscle

  5. AMPKg3 is involved in the coordinated transcription of genes critical for lipid and glucose metabolism in white glycolytic skeletal muscle.

  6. analysis of transcriptional regulation in skeletal muscle of AMP-activated protein kinase (show PRKAA2 Proteins) gamma3 R225Q transgenic and knock-out mice

  7. Expression of either wild type or mutant (R225Q) gamma3-subunit of AMPK (show PRKAA1 Proteins) results in increased glycogen (show GYS1 Proteins) concentrations in muscle, but the mechanisms underlying this alteration appear to be different.

  8. AMPK (show PRKAA1 Proteins) heterotrimeric complexes containing the AMPKgamma(3) subunit may play a specific role in linking circadian oscillators and energy metabolism in skeletal muscle.

  9. Basal and A-769662-mediated IL-6 (show IL6 Proteins) release provide evidence for a role of AMPK (show PRKAA1 Proteins) in the regulation of IL-6 (show IL6 Proteins) release from oxidative skeletal muscle.

  10. AMPK gamma3 subunit is associated with mitochondrial biogenesis in glycolytic skeletal muscle, concomitant with increased expression of the co-activator PGC-1alpha and several transcription factors that regulate mitochondrial proteins

PRKAG3 Protein Profile

Protein Summary

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle.

Alternative names and synonyms associated with PRKAG3

  • protein kinase, AMP-activated, gamma 3 non-catalytic subunit (Prkag3)
  • protein kinase, AMP-activated, gamma 3 non-catalytic subunit (PRKAG3)
  • protein kinase, AMP-activated, gamma 3 non-catalytic subunit (prkag3)
  • protein kinase, AMP-activated, gamma 3 non-catatlytic subunit b (prkag3-b)
  • protein kinase, AMP-activated, gamma 3 non-catatlytic subunit (Prkag3)
  • Amkg3 protein
  • AMPKG3 protein
  • AMPKg3L protein
  • AMPKg3S protein
  • PRKAG3 protein
  • prkag3-a protein

Protein level used designations for PRKAG3

5'-AMP-activated protein kinase subunit gamma-3 , AMP-activated protein kinase gamma 3 subunit , protein kinase, AMP-activated, gamma 3 non-catatlytic subunit , 5'-AMP-activated protein kinase gamma-3 non-catalytic subunit long form , AMP-activated protein kinase gamma subunit , protein kinase non-catalytic gamma subunit , AMP-activated protein kinase, non-catalytic gamma-3 subunit , AMP-activated protein kinase gamma 3 , AMPK-activated protein kinase gamma-3 subunit , protein kinase, AMP-activated, gamma 3 non-catalytic subunit a , protein kinase, AMP-activated, gamma 3 non-catalytic subunit , AMP-activated protein kinase subunit gamma , 5'-AMP-activated protein kinase subunit gamma-3-like , 5'-AMP-activated protein kinase, gamma-3 subunit , AMPK gamma-3 chain , AMPK gamma3 , AMPK subunit gamma-3 , 5'-AMP-activated protein kinase gamma-3 subunit , AMP-activated protein kinase gamma

GENE ID SPECIES
301518 Rattus norvegicus
424208 Gallus gallus
470648 Pan troglodytes
488526 Canis lupus familiaris
100034099 Equus caballus
100127310 Xenopus laevis
100142674 Ovis aries
100352581 Oryctolagus cuniculus
100394141 Callithrix jacchus
380124 Xenopus laevis
53632 Homo sapiens
511961 Bos taurus
397149 Sus scrofa
241113 Mus musculus
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