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anti-Human SREBF1 Antibodies:
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Chicken Monoclonal SREBF1 Primary Antibody for SimWes, WB - ABIN153469
Yin, Zhang, Hillgartner: Sterol regulatory element-binding protein-1 interacts with the nuclear thyroid hormone receptor to enhance acetyl-CoA carboxylase-alpha transcription in hepatocytes. in The Journal of biological chemistry 2002
Show all 22 Pubmed References
Cow (Bovine) Polyclonal SREBF1 Primary Antibody for ICC, IF - ABIN151638
Johnston-Cox, Koupenova, Yang, Corkey, Gokce, Farb, LeBrasseur, Ravid: The A2b adenosine receptor modulates glucose homeostasis and obesity. in PLoS ONE 2012
Show all 9 Pubmed References
Hamster Monoclonal SREBF1 Primary Antibody for IP, WB - ABIN967563
Sakai, Nohturfft, Cheng, Ho, Brown, Goldstein: Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein. in The Journal of biological chemistry 1997
Show all 4 Pubmed References
Human Monoclonal SREBF1 Primary Antibody for EMSA, IP - ABIN2668814
Daniëls, Smans, Royaux, Chypre, Swinnen, Zaidi: Cancer cells differentially activate and thrive on de novo lipid synthesis pathways in a low-lipid environment. in PLoS ONE 2014
Show all 2 Pubmed References
Human Polyclonal SREBF1 Primary Antibody for ICC, IF - ABIN4355907
Dahlhoff, Worsch, Sailer, Hummel, Fiamoncini, Uebel, Obeid, Scherling, Geisel, Bader, Daniel: Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels. in Molecular metabolism 2014
Cow (Bovine) Polyclonal SREBF1 Primary Antibody for ICC, IF - ABIN4355909
Johnson, McDowell, Viereck, Xia: Species-specific dibutyl phthalate fetal testis endocrine disruption correlates with inhibition of SREBP2-dependent gene expression pathways. in Toxicological sciences : an official journal of the Society of Toxicology 2011
In vivo, the data of established transgenic animals showed that mice with lncHR1 expression had less hepatic expression of SREBP-1c, FAS, Acetyl-CoA carboxylase alpha (ACCalpha), and less he (show FASN Antibodies)patic and plasma TG after being fed a high-fat diet.
dysregulation of SIRT1 (show SIRT1 Antibodies)-AMPK (show PRKAA1 Antibodies)-SREBP and stimulation of NLRP3 (show NLRP3 Antibodies) inflammasome may contribute to vascular lipid deposition and inflammation in atherosclerosis
Polymorphisms of the ACACA (show ACACA Antibodies) and SREBF1 genes are promising markers for pig carcass and performance traits.
IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.
Basal transcription and supra-additive stimulation of porcine LDLR (show LDLR Antibodies) gene transcription by LH and insulin (show INS Antibodies) in granulosa-luteal cells require SREBP-1a and Sp1 (show SP1 Antibodies)/Sp3 (show SP3 Antibodies)-binding elements.
Results of associated analysis show that the polymorphism of ADD1 gene was associated traits of Intramuscular fat content (IMF (show MDFI Antibodies)) and back fat thickness (BF).
SREBF1 might play an important role in regulation of muscle fat deposition during postnatal growth of pigs.
SREBP1a activated while C/EBP (show CEBPA Antibodies) factors downregulated the activity of the SCD1 (show SCD Antibodies) promoter.
These results suggest that increased expression of hepatic CD36 (show CD36 Antibodies) and SREBP-1 is relevant in the obesity-driven lipid accumulation in the liver of dairy cows during late gestation.
Hepatic SREBP-1c-mediated lipid synthesis and the NF-kappaB (show NFKB1 Antibodies) inflammatory pathway were both overinduced in cows with fatty liver.
SREBP1 was found to be a key positive regulator of milk fat synthesis and was shown to be regulated by stearic acid and serum.
data suggest that low SREBP-1c expression can decrease lipid synthesis, increase lipid oxidation, and decrease the TG and VLDL content in bovine hepatocytes
84-bp indel in intron 5 was significantly associated with palmitoleic acid, stearic acid, saturated fatty acids, triglycerides and the C16 index in Simmental bulls.
genetic polymorphisms in sterol regulatory element binding transcription factor 1 (SREBF1)can be used to develop genetic tools for the selection of animals producing milk with healthier fatty acid composition
The results of this study demonstrated the existence of the polymorphisms in the SCD1 (show SCD Antibodies) and SREBP-1 genes in the population of Fleckvieh cattle and their associations with the concentrations of several muscle fat and subscutaneous fat fatty acids.
These results provide detailed genetic information for the SREBP1 signalling pathway and SCD (show SCD Antibodies) that can be used to change milk fat composition by marker-assisted breeding.
The SREBP1-9 SNP showed a significant effect on marbling score, monounsaturated fatty acids and C18 (show BBS9 Antibodies):1n-9 in the muscle fat of commercial Korean cattle.
the ability of Pu-erh (show ERH Antibodies) tea in promoting inhibition of food uptake and the biosynthesis of fat via SBP-1 and SCD (show SCD Antibodies), thereby reducing fat storage.
SBP-1/SREBP-1 is part of a conserved feedback loop responding to phosphatidylcholine (show SGMS1 Antibodies) levels to regulate expression of one-carbon cycle biogenesis genes and ensure adequate S-adenosylmethionine levels for phosphatidylcholine (show SGMS1 Antibodies) production.
elo-5 and elo-6 may be transcriptional targets of LPD (show ACSBG1 Antibodies)-1
both SBP-1 and MDT-15 control transcription of genes governing desaturation of stearic acid to oleic acid
Essential role of sbp-1 activation in oxygen deprivation induced lipid accumulation and increase in body width/length ratio in Caenorhabditis elegans.
Variants in the TOM1L2/SREBF1 (show TOM1L2 Antibodies) locus exert opposing effects of total-body lean mass (TB-LM) and total-body less head bone mineral density (TBLH-BMD (show BEST1 Antibodies)) .
Date indicate that sterol regulatory element-binding proteins Srebp1 and Srebp2 (show SREBF2 Antibodies) are essential for the metabolic reprogramming of NK cells and for the attainment of elevated glycolysis and oxidative phosphorylation.
Study identified a novel human specific lncRNA, lncHR1, as a negative regulator of SREBP-1c expression. Overexpression of lncHR1 inhibited expression of SREBP-1c and fatty acid synthase (FAS (show FASN Antibodies)) and then repressed oleic acid-induced hepatic cell triglyceride (TG) and lipid droplet (LD) accumulation.
Glucose adsorption to chitosan membranes increases proliferation of human chondrocytes via mammalian target of rapamycin (show FRAP1 Antibodies) complex 1 and sterol regulatory element-binding protein-1 signaling.
miR (show MLXIP Antibodies)-185 negatively regulates the differentiation of 3T3-L1 cells by targeting SREBP-1
The authors further demonstrated that the upregulation of sterol regulatory element-binding protein (show CNBP Antibodies) (SREBP)-1c by activation of the Akt (show AKT1 Antibodies) and p70S6K (show RPS6KB1 Antibodies) pathways is critical for high-glucose-treated Porphyromonas gingivalis-induced NLRP3 (show NLRP3 Antibodies) expression.
Results show that PPARalpha (show PPARA Antibodies) is downregulated and SREBP-1c is upregulated in steatosis L-02 cells. These changes increase lipid synthesis and reduce lipid disposal, which ultimately lead to hepatic steatosis.
SREBP-1 and SREBP-2 (show SREBF2 Antibodies) mRNA expression levels were measured in EAT from 49 patients with CAD (show CAD Antibodies) (26 with diabetes) and 23 controls without CAD (show CAD Antibodies) or diabetes.SREBP expression was associated as cardiovascular risk factor for the severity of CAD (show CAD Antibodies) and the poor lipid control.
The involvement of SREBP-1c in FASN (show FASN Antibodies) promoter histone modification.
the mitotic phosphorylation and stabilization of nuclear SREBP1 during cell division provides a link between lipid metabolism and cell proliferation.
The deletion of Srebf-2 (show SREBF2 Antibodies) and subsequent lower sterol synthesis in hepatocytes eliminated the production of an endogenous sterol ligand required for LXR (show NR1H3 Antibodies) activity and SREBP-1c expression.
The fasting-induced transcription factor KLF15, a key regulator of gluconeogenesis, forms a complex with LXR (show NR1H3 Antibodies)/RXR, specifically on the Srebf1 (show TOM1L2 Antibodies) promoter.
Exposure to a xenobiotic during early development induced persistent fat accumulation via hypomethylation of lipogenic genes. Moreover, increased Nrf2 (show NFE2L2 Antibodies) recruitment to the Srebp-1c promoter in livers of BPA (show DST Antibodies)-exposed mice was observed.
suggesting a specific effect of sterol regulatory element binding protein (show CNBP Antibodies)-1c on neurosteroidogenesis
Transforming growth factor-beta activated kinase 1 (TAK1 (show MAP3K7 Antibodies)) regulation of sterol-regulatory element-binding proteins (SREBPs) critically contributes to the maintenance of liver homeostasis to prevent steatosis, which is a potentially important mechanism to prevent hepatocellular carcinoma (HCC (show FAM126A Antibodies)) development.
SREBP1 pathway plays an important role in hepatocellular carcinoma pathogenesis.
In hepatocytes, E4BP4 (show NFIL3 Antibodies) interacts with nuclear SREBP-1c to preserve its acetylation, and subsequently protects it from ubiquitination-dependent degradation
SREBP1 also contributes to the resolution phase of TLR4 (show TLR4 Antibodies)-induced gene activation by reprogramming macrophage lipid metabolism.
27OH is not an important regulator of Srebp- or LXR regulated genes under basal conditions in mouse liver
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
, class D basic helix-loop-helix protein 1
, sterol regulatory element-binding protein 1
, adipocyte determination- and differentiation-dependent factor 1
, sterol regulatory element binding protein 1
, adipocyte determination and differentiation-dependent factor 1
, sterol regulatory binding transcription factor 1
, sterol regulatory element-binding transcription factor 1
, sterol regulatory element binding-protein 1
, sterol regulatory element binding transcription factor 1
, sterol response element binding protein 1
, similar to sterol regulatory element binding transcription factor 1 isoform b
, sterol regulatory element binding protein-1
, sterol regulatory element-binding protein 1-like
, Sterol regulatory element Binding Protein family member (sbp-1)
, Sterol regulatory element-binding transcription factor 1