Apoptosis Inhibitor of Macrophages (CD5L) (C-Term) antibody

Details for Product No. ABIN1001811
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Antigen
Epitope
C-Term
(1)
Reactivity
Human, Mouse (Murine)
(1), (1)
Host
Rabbit
(1)
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(1), (1), (1)
Pubmed 1 reference available
Quantity 100 µg
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Catalog No. ABIN1001811
514.01 $
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Immunogen AIM antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human AIM.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Background Apoptosis inhibitor of macrophages (AIM) is a member of the scavenger receptor cysteine-rich domain superfamily (SRCR-SF) initially identified as an inducible cell surface ligand of CD5. It was shown that AIM functions in the thymus as the inducer of resistance to apoptosis within CD4+/CD8+ thymocytes and as the supporter of the viability of these cells before thymic selection. AIM was also shown to support macrophage survival and enhance their phagocytic function. More recent experiments using recombinant AIM significantly inhibited apoptosis of NKT and T cells obtained from C. parvum-stimulated livers in vitro, suggesting that AIM functions to induce resistance to apoptosis in these cells and supports host defense against inflammation during infection.
Application Notes AIM antibody can be used for the detection of AIM by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Kuwata, Watanabe, Jiang et al.: "AIM inhibits apoptosis of T cells and NKT cells in Corynebacterium-induced granuloma formation in mice." in: The American journal of pathology, Vol. 162, Issue 3, pp. 837-47, 2003 (PubMed).

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