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B-Cell Receptor-Associated Protein 31 (BCAP31) (Internal Region) antibody

Details for Product No. ABIN1001854, Supplier: Login to see
Antigen
  • 6c6-ag
  • bap31
  • cdm
  • dxs1357e
  • BCAP31
  • Bap31
  • 6C6-AG
  • BAP31
  • CDM
  • DXS1357E
  • CALD1
  • caldesmon
  • si:bz30i22.4
  • si:rp71-30i22.4
  • zgc:56389
Epitope
Internal Region
34
14
7
7
4
3
3
3
2
2
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
133
32
30
5
4
2
2
1
1
1
1
Host
Rabbit
96
19
11
8
Clonality
Polyclonal
Conjugate
Un-conjugated
7
7
7
2
2
2
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
125
68
41
23
13
11
10
4
3
2
2
1
1
1
1
Supplier
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Immunogen Rabbit polyclol BAP31 antibody was raised against a 17 amino acid peptide from near the center of human BAP31 (Genbank accession No. NP_005736).
Blocking Peptide Blocking peptide for this product available: ABIN1004001
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name B-cell Receptor Associated Protein 31 (BCAP31 Antibody Abstract)
Background Bap31 and the related protein Bap29 are endoplasmic reticulum (ER) and ER-vesicle membrane proteins and members of the B-cell receptor-associated protein family. These two proteins are highly homologous and can form homo- and heterodimers. Bap31 is thought to be involved in the intracellular trafficking of several molecules such as MHC Class I molecules and CD11b/CD18. Bap31 may also play a role in the initiation of ER stress-induced apoptosis through its association with caspase-8 via a death effector domain in its cytoplasmic tail, possibly through the promotion of membrane fragmentation and the release of cytochrome c from mitochondria. Bap31 itself contains two caspase cleavage sites and is cleaved during apoptosis. The p20 fragment of Bap31, when expressed ectopically, is also a potent inducer cell death.
Pathways
Application Notes BAP31 antibody can be used for the detection of BAP31 by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Background publications Zen, Utech, Liu et al.: "Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils." in: The Journal of biological chemistry, Vol. 279, Issue 43, pp. 44924-30, 2004 (PubMed).

Ng, Nguyen, Kwan et al.: "p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum." in: The Journal of cell biology, Vol. 139, Issue 2, pp. 327-38, 1997 (PubMed).

Kim, Adachi, Nielsen et al.: "Two new proteins preferentially associated with membrane immunoglobulin D." in: The EMBO journal, Vol. 13, Issue 16, pp. 3793-800, 1994 (PubMed).