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BAX antibody (BCL2-Associated X Protein) (N-Term)

Details for Product anti-BAX Antibody No. ABIN1001866, Supplier: Log in to see
Antigen
  • bax
  • fj16e01
  • wu:fc50b10
  • wu:fj16e01
  • bax-A
  • xBax
  • xlbax
  • BAX
  • BCL2L4
  • BAX-ALPHA
Alternatives
anti-Human BAX antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
N-Term
112
31
26
18
16
15
15
13
13
12
12
11
10
9
8
4
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
413
162
150
21
17
13
7
3
2
2
1
Host
Rabbit
307
140
4
Clonality
Polyclonal
Conjugate
This BAX antibody is un-conjugated
16
11
9
7
7
7
5
4
3
3
3
3
3
3
3
1
1
Application
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
311
175
126
91
79
67
35
32
19
10
6
6
2
2
1
1
1
1
1
1
1
Supplier
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Immunogen Rabbit polyclol Bax antibody was raised against a peptide corresponding to 16 amino acids near the amino-terminus of human Bax (GenBank accession no. AAA03619).
Blocking Peptide Blocking peptide for this product available: ABIN1004092
Isotype IgG
Purification Ion exchange chromatography purified.
Alternative Name Bax (Bcl-2 Associated X Protein) (BAX Antibody Abstract)
Background Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bax, a pro-apoptotic Bcl-2 family member, is a cytosolic protein that changes conformation and translocates to the mitochondria following apoptotic stimuli. It is thought to share significant functional homology with Bak, another pro-apoptotic Bcl-2 family member, as disruption of bax or bak has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking both show decreased apoptotic capability.
Pathways p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis
Application Notes Bax antibody can be used for detection of Bax by Western blot at 2 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Heiser, Labi, Erlacher et al.: "The Bcl-2 protein family and its role in the development of neoplastic disease." in: Experimental gerontology, Vol. 39, Issue 8, pp. 1125-35, 2004 (PubMed).

Cory, Huang, Adams: "The Bcl-2 family: roles in cell survival and oncogenesis." in: Oncogene, Vol. 22, Issue 53, pp. 8590-607, 2003 (PubMed).

Lockshin, Osborne, Zakeri: "Cell death in the third millennium." in: Cell death and differentiation, Vol. 7, Issue 1, pp. 2-7, 2000 (PubMed).

Background publications Oltvai, Milliman, Korsmeyer: "Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death." in: Cell, Vol. 74, Issue 4, pp. 609-19, 1993 (PubMed).