Bcl-B (Member of The Bcl-2 Family) antibody

Details for Product No. ABIN1001874
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Antigen
Reactivity
Human
Host
Rabbit
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
Pubmed 4 references available
Quantity 100 µg
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Catalog No. ABIN1001874
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Immunogen Bcl-B antibody was raised against a 16 amino acid peptide from near the amino terminus of human Bcl-B.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Background Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-B is a recently discovered anti-apoptotic member of the Bcl-2. Unlike the mouse homolog (also known as Diva/Boo) which is predominantly expressed in ovary and testis, the human Bcl-B protein is widely expressed. Also, the human Bcl-B functions by binding to and suppressing the apoptotic activity of Bax, whereas the mouse homolog binds Bak and also interacts with the apoptosis protein Apaf-1. Despite its predicted molecular weight, Bcl-B is often at higher molecular weights, presumably due to post-translational modifications.
Application Notes Bcl-B antibody can be used for the detection of Bcl-B by Western blot at 1 - 2 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Song, Kuang, Dixit et al.: "Boo, a novel negative regulator of cell death, interacts with Apaf-1." in: The EMBO journal, Vol. 18, Issue 1, pp. 167-78, 1999 (PubMed).

Ke, Godzik, Reed: "Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak." in: The Journal of biological chemistry, Vol. 276, Issue 16, pp. 12481-4, 2001 (PubMed).

Cory, Huang, Adams: "The Bcl-2 family: roles in cell survival and oncogenesis." in: Oncogene, Vol. 22, Issue 53, pp. 8590-607, 2003 (PubMed).

Heiser, Labi, Erlacher et al.: "The Bcl-2 protein family and its role in the development of neoplastic disease." in: Experimental gerontology, Vol. 39, Issue 8, pp. 1125-35, 2004 (PubMed).

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