PR Domain Containing 1, with ZNF Domain (PRDM1) (N-Term) antibody

Details for Product No. ABIN1001905, Supplier: Log in to see
Antigen
  • GB11750
  • CG5249
  • Dmel\\CG5249
  • blimp-1
  • dBlimp-1
  • dBlimp1
  • Blimp-1
  • Blimp1
  • nrd
  • prdm1
  • ubo
  • wu:fb99c12
  • zgc:91885
  • MGC52536
  • PRDM1
  • blimp1
  • xblimp1
  • prdi-bf1
  • BLIMP1
  • PRDI-BF1
  • ZNFPR1A1
  • PR domain containing 1, with ZNF domain
  • Blimp-1 protein
  • CG5249 gene product from transcript CG5249-RB
  • blimp-1
  • PR domain containing 1a, with ZNF domain
  • B lymphocyte induced maturation protein 1
  • PRDM1
  • LOC100338324
  • Blimp-1
  • CpipJ_CPIJ007425
  • prdm1a
  • prdm1
  • Prdm1
Alternatives
anti-Human PR Domain Containing 1, with ZNF Domain antibody for Western Blotting
Epitope
N-Term
29
21
15
12
11
9
9
8
7
7
7
5
5
5
5
4
3
3
2
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
177
72
37
28
13
10
5
4
3
3
3
2
1
Host
Rabbit
81
72
33
3
Clonality
Polyclonal
Conjugate
Un-conjugated
10
9
8
6
5
4
3
3
3
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
168
124
33
32
31
30
24
16
10
7
3
2
2
1
1
1
1
Options
Supplier
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Immunogen Blimp-1 antibody was raised against a 17 amino acid peptide from near the amino terminus of human Blimp-1.
Blocking Peptide Blocking peptide for this product available: ABIN1004099
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Blimp-1 (PRDM1 Antibody Abstract)
Background Blimp-1 was initially identified as a zinc finger-containing protein that drives the maturation of B lymphocytes into immunoglobulin-secreting cells. Together with X-box-binding protein 1 (XBP1), Blimp-1 is induced upon terminal differentiation of plasma cells. The transcriptional repressor activity of Blimp-1 has also been found to regulate T cell homeostasis and function, possibly by suppressing the expression of the cytokines IL-2 and interferon-gamma during T cell development. More recent experiments have suggested that Blimp-1 also plays a major role in the formation of primordial germ cells (PGC) in developing mammalian embryos. In these experiments, Blimp-1-deficient mutant mouse embryos form a cluster of PGC-like cells which fail to show the expected migration, proliferation, and repression of homeobox genes that normally accompany specification of primordial germ cells. Blimp-1 exists as at least two different isoforms.
Pathways Regulation of Muscle Cell Differentiation
Application Notes Blimp-1 antibody can be used for detection of Blimp-1 by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Martins, Cimmino, Shapiro-Shelef, Szabolcs, Herron, Magnusdottir, Calame: "Transcriptional repressor Blimp-1 regulates T cell homeostasis and function." in: Nature immunology, Vol. 7, Issue 5, pp. 457-65, 2006 (PubMed).

Reimold, Iwakoshi, Manis, Vallabhajosyula, Szomolanyi-Tsuda, Gravallese, Friend, Grusby, Alt, Glimcher: "Plasma cell differentiation requires the transcription factor XBP-1." in: Nature, Vol. 412, Issue 6844, pp. 300-7, 2001 (PubMed).

Background publications Angelin-Duclos, Cattoretti, Lin, Calame: "Commitment of B lymphocytes to a plasma cell fate is associated with Blimp-1 expression in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 10, pp. 5462-71, 2000 (PubMed).

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