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Details for Product No. ABIN1001909

BMI1 Polycomb Ring Finger Oncogene (BMI1) (Internal Region) antibody

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Antigen
Synonyms FLVI2/BMI1, PCGF4, RNF51, Bmi-1, Pcgf4, AW546694, BMI-1, bmi1, pcgf4, psc1, wu:fb17g03, wu:fd18f06
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
Pubmed 3 references available
Catalog no. ABIN1001909
Quantity 100 µg
Price
514.01 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 7 Business Days
Immunogen BMI-1 antibody was raised against a peptide corresponding to 15 amino acids near the center of human BMI-1. Antigen: Human BMI-1 (Intermediate Domain) Peptide (Cat. No. PK-AB718-3755P).
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name BMI-1 (Polycomb Group RING Finger Protein 4, RNF51)
Background The transcriptional repressor BMI-1 was first identified as a proto-oncogene frequently activated by Moloney murine leukemia proviral insertions in mice and cooperating with c-myc in the generation of mouse lymphomas. BMI-1 is involved in segment specification, cell growth and maintenance, transcriptional regulation, and chromatin modification. A major target of BMI-1 is the ink4a locus which encodes tumor suppressor proteins p16 and p19Arf, which are important in tumor progression and thought to be critical in cell proliferation and senescence. Recent studies have also shown that BMI-1 is required for the maintenance of adult normal and leukemic stem cells, suggesting that BMI-1 could an attractive therapeutic target for stem cell proliferation and renewal as well as for anti-cancer strategies.
Application Notes BMI-1 antibody can be used for detection of BMI-1 by Western blot at 0.5 to 1 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Alkema, Wiegant, Raap et al.: "Characterization and chromosomal localization of the human proto-oncogene BMI-1." in: Human molecular genetics, Vol. 2, Issue 10, pp. 1597-603, 1994 (PubMed).

Jacobs, Kieboom, Marino et al.: "The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus." in: Nature, Vol. 397, Issue 6715, pp. 164-8, 1999 (PubMed).

Lessard, Sauvageau: "Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells." in: Nature, Vol. 423, Issue 6937, pp. 255-60, 2003 (PubMed).

Alternatives for antigen "BMI1 Polycomb Ring Finger Oncogene (BMI1)", type "Antibodies"
Hosts (91), (31), (10)
Reactivities (119), (58), (41), (20), (19), (18), (9), (6), (6), (3), (2), (1), (1)
Applications (116), (48), (26), (22), (21), (19), (10), (7), (6), (2), (2), (2), (1), (1), (1), (1), (1)
Conjugates (6), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (8), (8), (6), (4), (3), (2), (2), (1), (1), (1), (1), (1)
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