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Details for Product No. ABIN1001943

BR serine/threonine Kinase 2 (BRSK2) antibody

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Antigen
Synonyms C11orf7, PEN11B, SAD1, SADA, STK29, SAD-A, 4833424K13Rik, BRSK2
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN1001943
Quantity 100 µg
Price
514.01 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 7 Business Days
Immunogen BRSK2 antibody was raised in rabbits against a 23 amino acid peptide from near the carboxy terminus of human BRSK2.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name BRSK2
Background BRSK2 was initially identified through a computer screen of the human genome and shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK2 is expressed in the brain and to a lesser extent in the testes. BRSK2 is a member of the AMP-activated protein kinase subfamily and can be activated by the tumor suppressor kinase LKB1. More recently, it has been shown that both BRSK2 and the related protein BRSK1 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. BRSK2 has also been shown to be an autoantigen in paraneoplastic limbic encephalitis. At least four isoforms of BRSK2 are known to exist.
Research Area Neurology, DNA/RNA
Application Notes BRSK2 antibody can be used for detection of BRSK2 by Western blot at 1 – 2 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Manning, Whyte, Martinez et al.: "The protein kinase complement of the human genome." in: Science (New York, N.Y.), Vol. 298, Issue 5600, pp. 1912-34, 2002 (PubMed).

Lizcano, Göransson, Toth et al.: "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1." in: The EMBO journal, Vol. 23, Issue 4, pp. 833-43, 2004 (PubMed).

Kishi, Pan, Crump et al.: "Mammalian SAD kinases are required for neuronal polarization." in: Science (New York, N.Y.), Vol. 307, Issue 5711, pp. 929-32, 2005 (PubMed).

Sabater, Gómez-Choco, Saiz et al.: "BR serine/threonine kinase 2: a new autoantigen in paraneoplastic limbic encephalitis." in: Journal of neuroimmunology, Vol. 170, Issue 1-2, pp. 186-90, 2005 (PubMed).

Alternatives for antigen "BR serine/threonine Kinase 2 (BRSK2)", type "Antibodies"
Hosts (35), (5), (2)
Reactivities (37), (26), (17), (14), (13), (12), (12)
Applications (28), (18), (10), (10), (8), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (3), (2), (2), (2), (1), (1), (1), (1)
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