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CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence)

Details for Product anti-CBL Antibody No. ABIN1001990, Supplier: Login to see New
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Synonyms 4732447J05Rik, Cbl-2, c-Cbl, cbl, C-CBL, CBL2, FRA11B, NSLL, RNF55, c-cbl-like, RGD1561386
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Human, Mouse (Murine), Rat (Rattus)
(238), (132), (126), (6), (4), (4), (4), (1), (1), (1)
(198), (33), (11), (1)
This CBL antibody is un-conjugated
(7), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (2)
Fluorescence Microscopy (FM), ELISA, Western Blotting (WB)
(160), (67), (59), (56), (54), (34), (22), (18), (9), (5), (4), (3), (3), (1), (1), (1), (1)
Pubmed 3 references available
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Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 15 to 19 Business Days
Immunogen Cbl antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human cbl.
Blocking Peptide Blocking peptide for this product available: ABIN1004304
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Casitas B-lineage Lymphoma Proto-Oncogene (CBL Antibody Abstract)
Background The mammalian cbl family of ubiquitin ligases consists of three homologs known as cbl (also known as c-Cbl), Cbl-B, and Cbl-3 which share highly conserved a tyrosine-kinase-binding domain, linker and RING finger domain in their amino-terminal halves. Similar to other E3 ubiquitin ligases, Cbl catalyzes the transfer of ubiquitin from an E2 or Ubc (ubiquitin-conjugating) enzyme to the e-amino group of a lysine residue of the substrate protein. Cbl acts to negatively regulate many types of cell-surface receptors, including the Syk protein tyrosine kinase family. Cbl is thought to be involved in T- and B-cell signaling, in addition to thymus development. Of the three known homologs in the cbl family, cbl antibody reacts specifically with cbl. Multiple isoforms of cbl have been reported.
Pathways TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway
Application Notes Cbl antibody can be used for detection of cbl by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunofluorescence microscopy and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Thien, Langdon: "c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses." in: The Biochemical journal, Vol. 391, Issue Pt 2, pp. 153-66, 2005 (PubMed).

Background publications Swaminathan, Tsygankov: "The Cbl family proteins: ring leaders in regulation of cell signaling." in: Journal of cellular physiology, Vol. 209, Issue 1, pp. 21-43, 2006 (PubMed).

Weissman: "Themes and variations on ubiquitylation." in: Nature reviews. Molecular cell biology, Vol. 2, Issue 3, pp. 169-78, 2001 (PubMed).

Catalog No. ABIN1001990
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