Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN1002012

Caspase 5 (Inflammatory Subfamily) (Internal Region) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
Pubmed 4 references available
Catalog no. ABIN1002012
Quantity 100 µg
Price
514.01 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 6 to 7 Business Days
Immunogen Rabbit polyclol caspase-5 antibody was raised against a 14 amino acid peptide from the center of human caspase-5 (Genbank accession No. P51878).
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Background Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18. Caspase-5 can interact with caspase-1, both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1beta. Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-gamma.
Application Notes Casp-5 antibody can be used for the detection of caspase-5 by Western blot at 0.5 - 1 µg/mlDepending on cell lines or tissues used, other cleavage products may be observed. Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Kuida, Lippke, Ku et al.: "Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme." in: Science (New York, N.Y.), Vol. 267, Issue 5206, pp. 2000-3, 1995 (PubMed).

Martinon, Burns, Tschopp: "The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta." in: Molecular cell, Vol. 10, Issue 2, pp. 417-26, 2002 (PubMed).

Gracie, Robertson, McInnes: "Interleukin-18." in: Journal of leukocyte biology, Vol. 73, Issue 2, pp. 213-24, 2003 (PubMed).

Martinon, Tschopp: "Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases." in: Cell, Vol. 117, Issue 5, pp. 561-74, 2004 (PubMed).

Alternatives for antigen "Caspase 5 (Inflammatory Subfamily)", type "Antibodies"
Hosts (1)
Reactivities (1)
Applications (1), (1)
Epitopes (1)
Beacon