Duffy Blood Group, Chemokine Receptor (DARC) (N-Term) antibody

Details for Product No. ABIN1002191
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Antigen
Synonyms DARC, FY, ACKR1, CCBP1, CD234, Dfy, GPD, GpFy, WBCQ1, AA162249, Ackr1, ESTM35
Epitope
N-Term
(28), (13), (8), (4), (1), (1), (1), (1)
Reactivity
Human
(65), (27), (23)
Host
Rabbit
(62), (8), (7), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(55), (44), (26), (17), (15), (9), (9), (5), (4), (1), (1)
Pubmed 2 references available
Quantity 100 μg
Shipping to United States (Change)
Availability Will be delivered in 6 to 7 Business Days
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Catalog No. ABIN1002191
514.01 $
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Immunogen DARC antibody was raised in rabbits against a 18 amino acid peptide from near the amino terminus of human DARC.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name DARC
Background DARC, also known as the Duffy antigen/chemokine receptor, is a seven-transmembrane protein homologous to the classical chemokine G-protein coupled receptors (GPCRs) with the exception of the motif required for G protein coupling. DARC can bind with high affinity several chemokines without transducing any signal, suggesting it may modulate the signals normally induced by these chemokines. Recently, DARC was found to interact with KAI1, a four transmembrane protein recently identified as a tumor metastasis suppressor protein. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least three isoforms of DARC are known to exist.
Application Notes DARC antibody can be used for detection of DARC by Western blot at 1 – 2 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Chaudhuri, Polyakova, Zbrzezna et al.: "Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 22, pp. 10793-7, 1993 (PubMed).

Gardner, Patterson, Ashton et al.: "The human Duffy antigen binds selected inflammatory but not homeostatic chemokines." in: Biochemical and biophysical research communications, Vol. 321, Issue 2, pp. 306-12, 2004 (PubMed).

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