Daxx (Death Associated Protein, Adaptor Molecule) (C-Term) antibody

Details for Product No. ABIN1002192
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Antigen
Epitope
C-Term
Reactivity
Human, Mouse (Murine)
Host
Rabbit
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
Pubmed 2 references available
Quantity 100 μg
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Catalog No. ABIN1002192
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Immunogen Daxx antibody was raised against a peptide corresponding to amino acids near the carboxy-terminus of human Daxx
Isotype IgG
Purification Antibody is purified via DEAE-column chromatography.
Background Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.
Application Notes Daxx antibody can be used for detection of Daxx by Western blot at 1 – 2 µg/ml. (Optimal dilution should be determined by user.) HeLa whole cell lysate can be used as a positive control and a 120 kDa major band can be detected. Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far. Daxx antibody is human, mouse, and rat reactive.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Yang, Khosravi-Far, Chang et al.: "Daxx, a novel Fas-binding protein that activates JNK and apoptosis." in: Cell, Vol. 89, Issue 7, pp. 1067-76, 1997 (PubMed).

Kiriakidou, Driscoll, Lopez-Guisa et al.: "Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region." in: DNA and cell biology, Vol. 16, Issue 11, pp. 1289-98, 1998 (PubMed).

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