DC-SIGN (Novel HIV Binding Protein) (C-Term) antibody

Details for Product No. ABIN1002193
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Antigen
Epitope
C-Term
(1)
Reactivity
Human
(1)
Host
Rabbit
(1)
Clonality
Polyclonal
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(1), (1), (1)
Pubmed 4 references available
Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 6 to 7 Business Days
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Immunogen Rabbit polyclol DC-SIGN antibody was raised against a synthetic peptide corresponding to amino acids near the center of human DC-DIGN .
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Background Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
Application Notes DC-SIGN antibody can be used for detection of DC-SIGN by Western blot at 1 to 2 µg/ml. (Optimal dilution should be determined by user.) A band at approximately 44 kDa can be detected. Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Pöhlmann, Baribaud, Lee et al.: "DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus." in: Journal of virology, Vol. 75, Issue 10, pp. 4664-72, 2001 (PubMed).

Soilleux, Barten, Trowsdale: "DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 6, pp. 2937-42, 2000 (PubMed).

Geijtenbeek, Kwon, Torensma et al.: "DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells." in: Cell, Vol. 100, Issue 5, pp. 587-97, 2000 (PubMed).

Geijtenbeek, Torensma, van Vliet et al.: "Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses." in: Cell, Vol. 100, Issue 5, pp. 575-85, 2000 (PubMed).

Validation Images
Catalog No. ABIN1002193
452.54 $
Plus shipping costs $45.00
Quantity
Price
100 μg
452.54 $

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