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DAPK2 antibody (Death-Associated Protein Kinase 2)

Details for Product anti-DAPK2 Antibody No. ABIN1002201, Supplier: Log in to see
Antigen
  • dapk2
  • DAPK2
  • DRP-1
  • drp-1
  • DRP1
  • drp1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
138
74
53
6
3
2
1
1
1
Host
Rabbit
113
20
13
Clonality
Polyclonal
Conjugate
This DAPK2 antibody is un-conjugated
6
6
6
5
5
5
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
106
77
55
32
12
11
8
4
3
2
Supplier
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Immunogen Rabbit polyclol DAPK2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DAPK2 . The sequence of this antigenic peptide is identical to the corresponding amino acids of mouse origin.
Blocking Peptide Blocking peptide for this product available: ABIN1004322
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Death Associated Protein Kinase 2 (DAPK2 Antibody Abstract)
Background Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as RIP and DAP kinase, are mediators of apoptosis. DAP kinase (DAPK) is pro-apoptotic calcium-regulated serine/threonine kinase containing death domain. Ectopic expression of DAPK induces cell death and suppresses oncogenic transformation. DAPK mediates IFNg induced apoptosis. A novel DAP kinase-related protein was recently identified and designated DAPK2 and DRP-1. Ectopicly expressed DAPK2 induced apoptosis in various types of cells. DAPK has high sequence homology to ZIP kinase and DRAK1/2, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. The messenger RNA of DAPK2 is expressed in multiple human tissues.
Application Notes DAPK2 antibody can be used for detection of DAPK2 by Western blot at 0.5 to 1 µg/ml. (Optimal dilution should be determined by user.) An approximately 42 kDa band can be detected. DAPK2 has no cross responses to DAPK1. Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Background publications Inbal, Shani, Cohen, Kissil, Kimchi: "Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis." in: Molecular and cellular biology, Vol. 20, Issue 3, pp. 1044-54, 2000 (PubMed).

Kawai, Nomura, Hoshino, Copeland, Gilbert, Jenkins, Akira: "Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity." in: Oncogene, Vol. 18, Issue 23, pp. 3471-80, 1999 (PubMed).