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Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25) (Extracellular Domain) antibody

Details for Product No. ABIN1002203
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Antigen
Synonyms DR3, TR3, DDR3, LARD, APO-3, TRAMP, WSL-1, WSL-LR, TNFRSF12, Wsl, Tnfrsf12, TNFRSF25
Epitope
Extracellular Domain
(15), (14), (12), (7), (5), (4), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(118), (54), (26), (1)
Host
Rabbit
(103), (17), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(7), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
(97), (52), (16), (13), (10), (9), (6), (6)
Pubmed 4 references available
Quantity 100 µg
Shipping to United States (Change)
Availability Will be delivered in 6 to 7 Business Days
Catalog No. ABIN1002203
514.01 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Rabbit polyclol DR3 antibody was raised against a peptide corresponding to amino acids in extracellular domain (ED) of human DR3 precusor.
Isotype IgG
Purification Antibody is purified via DEAE-column chromatography.
Alternative Name Death Receptor 3
Background Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-kappaB activation.
Application Notes DR3 antibody can be used for detection of DR3 expression by Western blot at 1 – 2 µg/ml. (Optimal dilution should be determined by user.) Jurkat total cell lysate can be used as positive control and a 59 kDa band should be detected. Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far. DR3 antibody is human and mouse reactive.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Chinnaiyan, ORourke, Yu et al.: "Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95." in: Science (New York, N.Y.), Vol. 274, Issue 5289, pp. 990-2, 1996 (PubMed).

Kitson, Raven, Jiang et al.: "A death-domain-containing receptor that mediates apoptosis." in: Nature, Vol. 384, Issue 6607, pp. 372-5, 1996 (PubMed).

Marsters, Sheridan, Donahue et al.: "Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B." in: Current biology : CB, Vol. 6, Issue 12, pp. 1669-76, 1997 (PubMed).

Bodmer, Burns, Schneider et al.: "TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)." in: Immunity, Vol. 6, Issue 1, pp. 79-88, 1997 (PubMed).

Hosts (103), (17), (1)
Reactivities (118), (54), (26), (1)
Applications (97), (52), (16), (13), (10), (9), (6), (6)
Conjugates (7), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (15), (14), (12), (7), (5), (4), (3), (2), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1002203
514.01 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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