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Details for Product No. ABIN1002204

Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25) (N-Term) antibody

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Antigen
Synonyms DR3, TR3, DDR3, LARD, APO-3, TRAMP, WSL-1, WSL-LR, TNFRSF12, Wsl, Tnfrsf12, TNFRSF25
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN1002204
Quantity 100 µg
Price
514.01 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 7 Business Days
Immunogen Rabbit polyclol DR3 antibody was raised against a peptide corresponding to amino acids 25 to 40 of human DR3 precusor.
Isotype IgG
Purification Antibody is purified via DEAE-column chromatography.
Alternative Name Death Receptor 3
Background Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-kappaB activation.
Application Notes DR3 antibody can be used for detection of DR3 by Western blot at 1:500 to 1:1000 dilution. (Optimal dilution should be determined by user.) Jurkat whole cell lysate can be used as positive control and a 59 kDa band can be detected. DR3 antibody is human and mouse reactive and has no cross reaction to other death receptors. Antibody can also be used for ELISA and might be suited for other applications not tested so far. This antibody is human and mouse reactive.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Chinnaiyan, ORourke, Yu et al.: "Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95." in: Science (New York, N.Y.), Vol. 274, Issue 5289, pp. 990-2, 1996 (PubMed).

Kitson, Raven, Jiang et al.: "A death-domain-containing receptor that mediates apoptosis." in: Nature, Vol. 384, Issue 6607, pp. 372-5, 1996 (PubMed).

Marsters, Sheridan, Donahue et al.: "Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B." in: Current biology : CB, Vol. 6, Issue 12, pp. 1669-76, 1997 (PubMed).

Bodmer, Burns, Schneider et al.: "TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)." in: Immunity, Vol. 6, Issue 1, pp. 79-88, 1997 (PubMed).

Alternatives for antigen "Tumor Necrosis Factor Receptor Superfamily, Member 25 (TNFRSF25)", type "Antibodies"
Hosts (103), (20), (1)
Reactivities (118), (52), (25), (1)
Applications (98), (43), (16), (13), (12), (10), (6), (6), (1)
Conjugates (7), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (16), (16), (12), (6), (6), (3), (2), (2), (1), (1), (1), (1), (1), (1)
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