TNFRSF25 antibody (Tumor Necrosis Factor Receptor Superfamily, Member 25) (N-Term)

Details for Product anti-TNFRSF25 Antibody No. ABIN1002204, Supplier: Log in to see
Antigen
  • TNFRSF25
  • APO-3
  • DDR3
  • DR3
  • LARD
  • TNFRSF12
  • TR3
  • TRAMP
  • WSL-1
  • WSL-LR
  • Tnfrsf12
  • Wsl
  • tumor necrosis factor receptor superfamily, member 25
  • TNFRSF25
  • Tnfrsf25
Alternatives
anti-Mouse (Murine) TNFRSF25 antibody for Blocking Reagent
Epitope
N-Term
15
15
14
13
12
12
11
11
9
6
5
4
4
4
3
2
2
2
2
1
1
Reactivity
Human, Mouse (Murine)
209
88
36
3
2
2
2
2
1
1
Host
Rabbit
151
64
4
1
Clonality
Polyclonal
Conjugate
This TNFRSF25 antibody is un-conjugated
13
10
5
5
4
4
4
4
4
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
126
58
54
26
23
20
12
8
5
2
2
2
2
1
1
Options
Supplier
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Immunogen Rabbit polyclol DR3 antibody was raised against a peptide corresponding to amino acids 25 to 40 of human DR3 precusor.
Blocking Peptide Blocking peptide for this product available: ABIN1004131
Isotype IgG
Purification Antibody is purified via DEAE-column chromatography.
Alternative Name Death Receptor 3 (TNFRSF25 Antibody Abstract)
Background Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-kappaB activation.
Pathways Apoptosis
Application Notes DR3 antibody can be used for detection of DR3 by Western blot at 1:500 to 1:1000 dilution. (Optimal dilution should be determined by user.) Jurkat whole cell lysate can be used as positive control and a 59 kDa band can be detected. DR3 antibody is human and mouse reactive and has no cross reaction to other death receptors. Antibody can also be used for ELISA and might be suited for other applications not tested so far. This antibody is human and mouse reactive.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Marsters, Sheridan, Donahue, Pitti, Gray, Goddard, Bauer, Ashkenazi: "Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-kappa B." in: Current biology : CB, Vol. 6, Issue 12, pp. 1669-76, 1997 (PubMed).

Bodmer, Burns, Schneider, Hofmann, Steiner, Thome, Bornand, Hahne, Schröter, Becker, Wilson, French, Browning, MacDonald, Tschopp: "TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)." in: Immunity, Vol. 6, Issue 1, pp. 79-88, 1997 (PubMed).

Background publications Chinnaiyan, ORourke, Yu, Lyons, Garg, Duan, Xing, Gentz, Ni, Dixit: "Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95." in: Science (New York, N.Y.), Vol. 274, Issue 5289, pp. 990-2, 1996 (PubMed).

Kitson, Raven, Jiang, Goeddel, Giles, Pun, Grinham, Brown, Farrow: "A death-domain-containing receptor that mediates apoptosis." in: Nature, Vol. 384, Issue 6607, pp. 372-5, 1996 (PubMed).