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TNFRSF10B antibody (Tumor Necrosis Factor Receptor Superfamily, Member 10b)

Details for Product anti-TNFRSF10B Antibody No. ABIN1002207, Supplier: Login to see New
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Synonyms TNFRSF10B, dr5, cd262, killer, trick2, trickb, xDR-M1, xDR-M2, ztnfr9, trailr2, trick2a, trick2b, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9, Ly98, MK
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Human, Mouse (Murine)
(262), (59), (19), (1), (1), (1)
(172), (112), (10), (8), (2), (2)
This TNFRSF10B antibody is un-conjugated
(19), (18), (14), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
(159), (107), (71), (42), (35), (30), (23), (23), (14), (12), (11), (4), (3), (3), (3), (1), (1)
Pubmed 4 references available
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Quantity 100 μg
Shipping to United States ( )
Availability Will be delivered in 15 to 19 Business Days
Immunogen Rabbit polyclol DR5 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human DR5 precursor .
Blocking Peptide Blocking peptide for this product available: ABIN1003787
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Death Receptor 5 (TNFRSF10B Antibody Abstract)
Background Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kappaB.
Pathways p53 Signaling, Apoptosis
Application Notes DR5 antibody can be used for detection of DR5 expression by Western blot at 1 – 2 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far. Whole cell lysate from HeLa cells can be used as positive control. DR5 antibody is human and mouse reactive and has no cross reaction to DR4.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Background publications MacFarlane, Ahmad, Srinivasula et al.: "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL." in: The Journal of biological chemistry, Vol. 272, Issue 41, pp. 25417-20, 1997 (PubMed).

Walczak, Degli-Esposti, Johnson et al.: "TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL." in: The EMBO journal, Vol. 16, Issue 17, pp. 5386-97, 1997 (PubMed).

Sheridan, Marsters, Pitti et al.: "Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors." in: Science (New York, N.Y.), Vol. 277, Issue 5327, pp. 818-21, 1997 (PubMed).

Pan, Ni, Wei et al.: "An antagonist decoy receptor and a death domain-containing receptor for TRAIL." in: Science (New York, N.Y.), Vol. 277, Issue 5327, pp. 815-8, 1997 (PubMed).

Catalog No. ABIN1002207
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