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Details for Product No. ABIN1002208

Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21) (N-Term) antibody

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Antigen
Synonyms BM-018, CD358, DR6, TR7, R74815, AA959878, TNFRSF21, dr6, im:6795346, wu:fa55e01, wu:fb02e11, wu:fc29a09, wu:fi27h08, tnfrsf21, MGC146356
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN1002208
Quantity 100 µg
Price
514.01 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 6 to 7 Business Days
Immunogen Rabbit polyclol DR6 antibody was raised against a peptide corresponding to amino acids 42 to 56 of human DR6 precursor .
Isotype IgG
Purification Antibody is purified via DEAE-column chromatography.
Alternative Name Death Receptor 6
Background Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kappaB.
Research Area Signaling, Apoptosis/Necrosis
Application Notes DR6 antibody can be used for detection of DR6 by Western blot at 1:500 to 1:2000 dilution. (Optimal dilution should be determined by user.) An approximately 68 kDa band can be detected. Antibody can also be used for ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Pan, Bauer, Haridas et al.: "Identification and functional characterization of DR6, a novel death domain-containing TNF receptor." in: FEBS letters, Vol. 431, Issue 3, pp. 351-6, 1998 (PubMed).

Alternatives for antigen "Tumor Necrosis Factor Receptor Superfamily, Member 21 (TNFRSF21)", type "Antibodies"
Hosts (67), (30), (7)
Reactivities (94), (22), (20), (17), (17), (16), (1), (1)
Applications (56), (44), (22), (20), (14), (9), (7), (6), (4), (4), (3), (1)
Conjugates (5), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (20), (10), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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