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serine/threonine Kinase 17b (STK17B) (C-Term) antibody

Details for Product No. ABIN1002227, Supplier: Login to see
Antigen
  • zgc:65989
  • STK17B
  • DRAK2
  • Drak2
  • 3110009A03Rik
  • AI120141
Epitope
C-Term
36
16
15
11
3
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
105
26
22
3
2
1
1
Host
Rabbit
83
18
6
Clonality
Polyclonal
Conjugate
Un-conjugated
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
79
39
18
15
11
10
8
3
2
2
2
Supplier
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Immunogen Rabbit polyclol DRAK2 antibody was raised against a peptide corresponding to amino acids 351 to 365 of human DRAK2 .
Blocking Peptide Blocking peptide for this product available: ABIN1003788
Isotype IgG
Purification Ion exchange chromatography purified.
Alternative Name DRAK2 (DAPK Related Apoptosis Inducing Kinase 2) (STK17B Antibody Abstract)
Background Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 (for DAP kinase-related apoptosis-inducing protein kinases) . DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK2 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK2 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.
Pathways
Application Notes DRAK2 antibody can be used for detection of DRAK2 by Western blot at 1:500 to 1:1000 dilution. (Optimal dilution should be determined by user.) An approximately 45 kDa band can be detected. It has no cross responses to DAP or ZIP kinases. The approximately 70 kDa band is probably non-related to DRAK2 although it is peptide blockable. Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Background publications Sanjo, Kawai, Akira: "DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis." in: The Journal of biological chemistry, Vol. 273, Issue 44, pp. 29066-71, 1998 (PubMed).